Target Information

Target General Infomation
Target ID
T21669
Former ID
TTDI02088
Target Name
Glutathione S-transferase P
Gene Name
GSTP1
Synonyms
GST classpi; GSTP11; GSTP1
Target Type
Clinical Trial
Disease Myelodysplastic syndrome [ICD9: 238.7; ICD10: D46]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
Conjugation of reducedglutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
BioChemical Class
Alkyl aryl transferase
UniProt ID
P09211
EC Number
EC 2.5.1.18
Sequence
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
Drugs and Mode of Action
Drug(s) Canfosfamide Drug Info Phase 3 Solid tumours [532490]
Ezatiostat Drug Info Phase 2 Myelodysplastic syndrome [523599]
Modulator Canfosfamide Drug Info [527097], [532490]
Ezatiostat Drug Info [550407]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Glutathione-mediated detoxification
4-hydroxy-2-nonenal detoxification
KEGG Pathway Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Pathways in cancer
Chemical carcinogenesis
Prostate cancer
NetPath Pathway TCR Signaling Pathway
References
Ref 523599ClinicalTrials.gov (NCT01422486) Phase 2 Study of Telintra in Deletion 5q Myelodysplastic Syndrome. U.S. National Institutes of Health.
Ref 532490Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78.
Ref 527097Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies. Clin Cancer Res. 2004 Jun 1;10(11):3689-98.
Ref 532490Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78.
Ref 550407National Cancer Institute Drug Dictionary (drug id 485244).

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