Target General Infomation |
Target ID |
T69506
|
Former ID |
TTDS00351
|
Target Name |
Orphan nuclear receptor NR1I3
|
Gene Name |
NR1I3
|
Synonyms |
CAR; Constitutive androstane receptor; Nuclear receptor CAR; Orphan nuclear receptor CAR; Orphan nuclear receptor MB67; NR1I3
|
Target Type |
Successful
|
Function |
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human cyp2b6 gene.
|
BioChemical Class |
Nuclear hormone receptor
|
UniProt ID |
|
Sequence |
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQV EFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYI KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
|
Drugs and Mode of Action |
Pathways |
References |
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