Target Information
Target General Infomation | |||||
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Target ID |
T63484
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Former ID |
TTDR00008
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Target Name |
Glucose-6-phosphate dehydrogenase
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Gene Name |
G6PD
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Synonyms |
G6PD
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Target Type |
Clinical Trial
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Disease | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10: J40-J44, J47] | ||||
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06] | |||||
Function |
Catalyzesthe rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
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BioChemical Class |
Short-chain dehydrogenases reductases
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Target Validation |
T63484
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UniProt ID | |||||
EC Number |
EC 1.1.1.49
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Sequence |
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | Pentose phosphate pathway | ||||
Pentose phosphate pathway (oxidative branch) | |||||
KEGG Pathway | Pentose phosphate pathway | ||||
Glutathione metabolism | |||||
Metabolic pathways | |||||
Biosynthesis of antibiotics | |||||
Carbon metabolism | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
PathWhiz Pathway | Pentose Phosphate Pathway | ||||
Warburg Effect | |||||
Reactome | TP53 Regulates Metabolic Genes | ||||
WikiPathways | Sulfation Biotransformation Reaction | ||||
NRF2 pathway | |||||
Nuclear Receptors Meta-Pathway | |||||
Vitamin D Receptor Pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in lymphocytes - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
Cori Cycle | |||||
Metabolism of carbohydrates | |||||
Pentose Phosphate Pathway | |||||
Glutathione metabolism | |||||
References | |||||
Ref 524778 | ClinicalTrials.gov (NCT02151006) Does Dehydro Epiandrosterone (DHEA) Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response?. U.S. National Institutes of Health. | ||||
Ref 529971 | Bioorg Med Chem. 2009 Mar 15;17(6):2483-9. Epub 2009 Feb 4.Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. | ||||
Ref 537753 | Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5. |
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