Drug General Information
Drug ID
D0I2FI
Former ID
DIB018049
Drug Name
dequalinium
Drug Type
Small molecular drug
Indication Myeloneuropathy [ICD10:G04.1] Clinical trial [526067]
Structure
Download
2D MOL
Formula
C30H40N4+2
InChI
InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
InChIKey
PCSWXVJAIHCTMO-UHFFFAOYSA-P
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) CNGA2 Target Info Blocker (channel blocker) [526973]
CNGA1 Target Info Blocker (channel blocker) [526498]
KCa2.1 Target Info Blocker (channel blocker) [525707]
KCa2.3 Target Info Blocker (channel blocker) [526067]
KCa2.2 Target Info Blocker (channel blocker) [525837]
References
Ref 526067Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
Ref 525707Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
Ref 525837Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7.
Ref 526067Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
Ref 526498Dequalinium: a novel, high-affinity blocker of CNGA1 channels. J Gen Physiol. 2003 Jan;121(1):37-47.
Ref 526973State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.