Drug General Information
Drug ID
D0UJ0K
Former ID
DIB021037
Drug Name
tetraethylammonium
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539487]
Formula
C8H20N+
InChI
InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
InChIKey
CBXCPBUEXACCNR-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 2 Target Info Blocker (channel blocker) [525854]
TRPV2 Target Info Blocker (channel blocker) [528975]
Kv1.6 Target Info Blocker (channel blocker) [532260]
KNa1.1 Target Info Blocker (channel blocker) [527608]
AQP1 Target Info Inhibitor [543916]
KCa2.2 Target Info Blocker (channel blocker) [530822]
Kir2.3 Target Info Blocker (channel blocker) [533867]
Kv1.8 Target Info Blocker (channel blocker) [525781]
KCa2.3 Target Info Blocker (channel blocker) [530822]
Kv1.2 Target Info Blocker (channel blocker) [533612]
Kv3.3 Target Info Blocker (channel blocker) [526804]
Kv2.2 Target Info Blocker (channel blocker) [534639]
Potassium channel KCNA1 Kv1.1 Target Info Blocker (channel blocker) [533612]
Potassium voltage-gated channel subfamily A member 3 Target Info Blocker (channel blocker) [533612]
KCa2.1 Target Info Blocker (channel blocker) [530822]
KNa1.2 Target Info Blocker (channel blocker) [528200]
Kv7.5 Target Info Blocker (channel blocker) [525770]
Potassium voltage-gated channel subfamily KQT member 4 Target Info Blocker (channel blocker) [529688]
Kv3.1 Target Info Blocker (channel blocker) [533612]
Potassium voltage-gated channel subfamily KQT member 3 Target Info Blocker (channel blocker) [525715]
Maxi K potassium channel Target Info Inhibitor [543803]
Kv4.1 Target Info Blocker (channel blocker) [526433]
KCa5.1 Target Info Blocker (channel blocker) [530535]
Potassium voltage-gated channel subfamily B member 1 Target Info Blocker (channel blocker) [528030]
Potassium voltage-gated channel subfamily A member 5 Target Info Blocker (channel blocker) [533612]
Kv3.4 Target Info Blocker (channel blocker) [526800]
Kv3.2 Target Info Blocker (channel blocker) [526249]
Kv1.7 Target Info Blocker (channel blocker) [526293]
KEGG Pathway Cholinergic synapsehsa04725:Cholinergic synapsehsa04725:Cholinergic synapsehsa04022:cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Insulin secretion
Salivary secretion
Pancreatic secretion
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
Interaction between L1 and AnkyrinsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channels
Interaction between L1 and AnkyrinsR-HSA-418457:cGMP effectsR-HSA-1296072:Voltage gated Potassium channels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionR-HSA-1296072:Voltage gated Potassium channels
WikiPathways Potassium Channels
L1CAM interactionsWP2669:Potassium ChannelsWP2669:Potassium Channels
BDNF signaling pathwayWP2669:Potassium ChannelsWP2669:Potassium Channels
L1CAM interactionsWP2669:Potassium Channels
Platelet homeostasisWP536:Calcium Regulation in the Cardiac Cell
Potassium ChannelsWP2669:Potassium Channels
References
Ref 539487(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2343).
Ref 525715Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol. 2000 Feb;129(3):413-5.
Ref 525770KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem. 2000 Aug 4;275(31):24089-95.
Ref 525781KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21.
Ref 525854Mol Pharmacol. 2000 Sep;58(3):591-600.Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Ref 526249Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol. 2002 Jan 15;538(Pt 2):405-19.
Ref 526293Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan;10(1):36-43.
Ref 526433Endogenous Kv channels in human embryonic kidney (HEK-293) cells. Mol Cell Biochem. 2002 Sep;238(1-2):69-79.
Ref 526800Characterization of a Shaw-related potassium channel family in rat brain. EMBO J. 1992 Jul;11(7):2473-86.
Ref 526804Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. Proc Biol Sci. 1992 Apr 22;248(1321):9-18.
Ref 527608For K+ channels, Na+ is the new Ca2+. Trends Neurosci. 2005 Aug;28(8):422-8.
Ref 528030Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9.
Ref 528200Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68.
Ref 528975Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol. 2007 Nov;72(5):1258-68. Epub 2007 Aug 2.
Ref 529688Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis. J Biol Chem. 2008 Nov 7;283(45):30668-76.
Ref 530535Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin). 2010 Jan-Feb;4(1):22-41. Epub 2010 Jan 2.
Ref 530822Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55.
Ref 532260Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 1990 Jun;9(6):1749-56.
Ref 533612Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34.
Ref 533867Cloning and expression of a novel human brain inward rectifier potassium channel. J Biol Chem. 1994 Aug 12;269(32):20468-74.
Ref 534639Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol. 1998 May;274(5 Pt 1):G901-11.
Ref 543803(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 380).
Ref 543916(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 688).

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