Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(3-trifluoromethyl-phenyl)-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(3-Chloro-phenyl)-2-ethyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Aminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)-methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-isobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)-methyl)quinolin-2(1H)-one | Drug Info |
| CAI --- CAIX | 6,7-Dimethoxy1-(4'-methylphenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(4-Chloro-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | N-((4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)-3-(1H-indol-3-yl)propan-1-amine | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-one oxime | Drug Info |
| 5HT1b --- SERT | (1R)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide | Drug Info |
| 5LOX --- HRH1 | 1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-furan-2-yl)-but-3-ynyl]-N-hydroxy-urea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-[3-(dimethylamino)propyl]-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine | Drug Info |
| ADRA1A --- HRH1 | SID49679166 | Drug Info |
| CABL --- Ckit | Imatinib | Drug Info |
| CABL --- MCSF | Sorafenib | Drug Info |
| CAI --- CAIX | 7-AMINO-4-METHYL-CHROMEN-2-ONE | Drug Info |
| Aurora --- VEGFR | 5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoic acid | Drug Info |
| AuroraA --- STK1 | N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenyl}urea | Drug Info |
| AuroraA --- STK1 | 2-(1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| AuroraA --- STK1 | 2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | 2,5,6,10,12-Pentahydro-3,8,8-trimethyl-9-oxopyrazolo[4,3:6,7]cyclohepta[1,2-b]pyrrolo[3,2-f]indole | Drug Info |
| AuroraA --- STK1 | N-(4-{1-Ethyl-4-[2-({[3-(4-methyl-1-piperazinyl)propyl]amino}-methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N-(4-(morpholinosulfonyl)phenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine | Drug Info |
| AuroraA --- STK1 | CHEMBL373013 | Drug Info |
| AuroraA --- STK1 | N,N-dimethyl-1-(4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)methanamine | Drug Info |
| B1R --- B2R | Bradykinin | Drug Info |
| Beta PDGFR --- CD135 | 1-(4-(6,7-dimethoxyquinazolin-4-yloxy)benzyl)-3-(3-methoxyphenyl)urea | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-(aminomethyl)benzyl)acetimidamide | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Methylaminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(2-{1-[2-(3H-imidazol-4-yl)-ethyl]-piperidin-4-ylamino}-benzothiazol-6-yl)-thiophene-2-carboxamidine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Hydrazino-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-((3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)(3-(benzo[d][1,3]dioxol-5-ylmethylamino)propyl)amino)acetonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(1-Methyl-pyrrolidin-2-ylmethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-(((1-(cyclopropylmethyl)piperidin-4-yl)(methyl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1221607 | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(benzofuran-5-ylmethyl)propane-1,3-diamine | Drug Info |
| 5HT1a --- SERT | 1-(3-Benzo[b]thiophen-2-yl-8-aza-bicyclo[3.2.1]oct-8-yl)-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(4,6-Dimethyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Quinolin-5-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1b --- SERT | (2-(benzo[b]thiophen-3-yl)cyclopropyl)-N,N-dimethylmethanamine | Drug Info |
| AChE --- NMDA | N-[4-(9H-Carbazol-4-yloxy)butyl]-N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine | Drug Info |
| ADRA1A --- HRH1 | 2-((3-phenylimidazolidin-1-yl)methyl)piperidine | Drug Info |
| ADRA1A --- HRH1 | 8-(3-Phenoxy-benzyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-(2-{[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]amino}ethyl)-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | Sorafenib | Drug Info |
| CABL --- TEK | Bosutinib | Drug Info |
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