Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T67162 Target Info
Target Name Dopamine D2 receptor (D2R)
Synonyms
Dopamine receptor 2; D(2) dopamine receptor
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Target Type Successful Target
Gene Name DRD2
Biochemical Class GPCR rhodopsin
UniProt ID
DRD2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Adrenergic receptor Alpha-2 (ADRA2) Successful Target
UniProt ID ADA2A_HUMAN; ADA2B_HUMAN; ADA2C_HUMAN
Gene Name NO-GeName
Synonyms
Alpha-2 adrenergic receptor; Alpha(2)-adrenoceptor
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Representative Drug(s) Naphazoline Drug Info IC50 = 0.0011 nM Click to Show More [1]
2 Naphazoline Drug Info IC50 = 0.0011 nM [1]
3 Risperidone Drug Info Ki = 1.8 nM [14]
4 Risperidone Drug Info Ki = 1.8 nM [14]
5 Phentolamine Drug Info Ki = 5 nM [46]
6 Phentolamine Drug Info Ki = 5 nM [46]
7 Quetiapine Drug Info Ki = 87 nM [35]
8 Quetiapine Drug Info Ki = 87 nM [35]
9 Olanzapine Drug Info Ki = 140 nM [14]
10 Olanzapine Drug Info Ki = 140 nM [14]
11 Ziprasidone Drug Info Ki = 390 nM [14]
12 Phenylephrine Drug Info Ki = 390 nM [92]
13 Ziprasidone Drug Info Ki = 390 nM [14]
14 Phenylephrine Drug Info Ki = 390 nM [92]
Co-Target Name Dopamine D3 receptor (D3R) Successful Target
UniProt ID DRD3_HUMAN
Gene Name DRD3
Synonyms
D(3) dopamine receptor
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Representative Drug(s) Haloperidol Drug Info IC50 = 0.06 nM Click to Show More [2]
2 Cariprazine Drug Info Ki = 0.085 nM [4]
3 Dopamine Drug Info EC50 = 0.11 nM [5]
4 Lisuride Drug Info Ki = 0.1413 nM [7]
5 ROXINDOLE Drug Info Ki = 0.4 nM [11]
6 Pramipexole Drug Info Ki = 0.7244 nM [7]
7 Pergolide Drug Info Ki = 0.8511 nM [7]
8 Aripiprazole Drug Info Ki = 1 nM [22]
9 Chlorpromazine Drug Info Ki = 1.585 nM [27]
10 Apomorphine Drug Info Ki = 2.6 nM [34]
11 Ropinirole Drug Info Ki = 2.9 nM [37]
12 Domperidone Drug Info Ki = 3.5 nM [40]
13 Meglitinides Drug Info Ki = 3.7 nM [40]
14 Amisulpride Drug Info Ki = 3.981 nM [27]
15 Chlorprothixene Drug Info Ki = 4.56 nM [43]
16 Abaperidone Drug Info Ki = 5.4 nM [47]
17 Sarizotan Drug Info IC50 < 6 nM [48]
18 Ziprasidone Drug Info Ki = 6.31 nM [27]
19 Risperidone Drug Info Ki = 6.7 nM [8]
20 Sulpiride Drug Info Ki = 8 nM [40]
21 Olanzapine Drug Info Ki = 19.95 nM [27]
22 Loxapine Drug Info IC50 = 22 nM [59]
23 Metoclopramide Drug Info Ki = 27 nM [40]
24 Talipexole Drug Info Ki = 67.61 nM [73]
25 Bromocriptine Drug Info Ki = 87 nM [12]
26 Sumanirole Drug Info EC50 = 186 nM [83]
27 Quetiapine Drug Info Ki = 251.19 nM [27]
Co-Target Name 5-HT 2A receptor (HTR2A) Successful Target
UniProt ID 5HT2A_HUMAN
Gene Name HTR2A
Synonyms
Serotonin receptor 2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2
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Representative Drug(s) Ziprasidone Drug Info Ki = 0.08 nM Click to Show More [3]
2 Risperidone Drug Info Ki = 0.15 nM [8]
3 OPC-34712 Drug Info Ki = 0.47 nM [6]
4 Aripiprazole Drug Info Ki = 0.8 nM [19]
5 Blonanserin Drug Info Ki = 0.81 nM [20]
6 Olanzapine Drug Info Ki = 1.585 nM [27]
7 Loxapine Drug Info Ki = 2.42 nM [33]
8 Chlorpromazine Drug Info IC50 = 3.4 nM [39]
9 Cariprazine Drug Info Ki = 18.8 nM [6]
10 Haloperidol Drug Info Ki = 25 nM [35]
11 Quetiapine Drug Info Ki = 31 nM [61]
12 Amisulpride Drug Info Ki = 630.96 nM [27]
Co-Target Name 5-HT 1A receptor (HTR1A) Successful Target
UniProt ID 5HT1A_HUMAN
Gene Name HTR1A
Synonyms
Serotonin receptor 1A; G-21; ADRBRL1; ADRB2RL1; 5-hydroxytryptamine receptor 1A; 5-HT1A receptor; 5-HT1A; 5-HT-1A
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Representative Drug(s) OPC-34712 Drug Info Ki = 0.12 nM Click to Show More [6]
2 Lisuride Drug Info Ki = 0.4 nM [12]
3 ROXINDOLE Drug Info IC50 = 0.8 nM [18]
4 Ziprasidone Drug Info Ki = 1.585 nM [27]
5 Aripiprazole Drug Info Ki = 1.7 nM [6]
6 Pergolide Drug Info Ki = 1.8 nM [29]
7 Cariprazine Drug Info Ki = 2.6 nM [6]
8 Sarizotan Drug Info IC50 < 6 nM [48]
9 Risperidone Drug Info Ki = 21 nM [14]
10 Bromocriptine Drug Info Ki = 24 nM [12]
11 Sumanirole Drug Info Ki = 73 nM [12]
12 Quetiapine Drug Info Ki = 79.43 nM [27]
13 Apomorphine Drug Info Ki = 296 nM [87]
14 Olanzapine Drug Info Ki = 610 nM [8]
15 Chlorpromazine Drug Info Ki = 673 nM [95]
Co-Target Name Opioid receptor sigma 1 (OPRS1) Successful Target
UniProt ID SGMR1_HUMAN
Gene Name SIGMAR1
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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Representative Drug(s) Haloperidol Drug Info Ki = 0.2 nM Click to Show More [9]
2 Iloperidone Drug Info IC50 = 64 nM [72]
3 Abaperidone Drug Info Ki = 490 nM [47]
4 Phentolamine Drug Info IC50 = 549.54 nM [93]
Co-Target Name 5-HT 2B receptor (HTR2B) Successful Target
UniProt ID 5HT2B_HUMAN
Gene Name HTR2B
Synonyms
Serotonin receptor 2B; 5-hydroxytryptamine receptor 2B; 5-HT2B; 5-HT-2B; 5-HT 2B
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Representative Drug(s) Aripiprazole Drug Info Ki = 0.36 nM Click to Show More [10]
2 OPC-34712 Drug Info Ki = 0.3981 nM [6]
3 Cabergoline Drug Info Ki = 1.4 nM [26]
4 Ziprasidone Drug Info Ki = 1.585 nM [27]
5 Olanzapine Drug Info Ki = 6.31 nM [27]
6 Risperidone Drug Info Ki = 19.95 nM [27]
7 Chlorpromazine Drug Info Ki = 39.81 nM [27]
8 Fluspirilene Drug Info Ki = 151.4 nM [81]
9 Quetiapine Drug Info Ki = 251.19 nM [27]
10 Amisulpride Drug Info Ki = 316.23 nM [27]
Co-Target Name Dopamine D4 receptor (D4R) Successful Target
UniProt ID DRD4_HUMAN
Gene Name DRD4
Synonyms
DRD4; D(2C)D(4) dopamine receptor dopamine receptor
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Representative Drug(s) Pramipexole Drug Info Ki = 0.49 nM Click to Show More [13]
2 Haloperidol Drug Info Ki = 0.74 nM [16]
3 Dopamine Drug Info Ki = 1.2 nM [24]
4 Apomorphine Drug Info EC50 = 4.3 nM [44]
5 Loxapine Drug Info Ki = 4.9 nM [45]
6 Sarizotan Drug Info IC50 < 6 nM [48]
7 Risperidone Drug Info Ki = 6.2 nM [47]
8 Ropinirole Drug Info Ki = 7.8 nM [37]
9 Olanzapine Drug Info Ki = 19 nM [57]
10 ROXINDOLE Drug Info Ki = 24 nM [11]
11 Chlorpromazine Drug Info Ki = 25.12 nM [27]
12 Ziprasidone Drug Info Ki = 32 nM [52]
13 Aripiprazole Drug Info Ki = 57.1 nM [22]
14 Lisuride Drug Info EC50 = 88.5 nM [75]
15 Cariprazine Drug Info Ki = 110 nM [77]
16 Abaperidone Drug Info Ki = 179 nM [47]
17 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name 5-HT 2C receptor (HTR2C) Successful Target
UniProt ID 5HT2C_HUMAN
Gene Name HTR2C
Synonyms
Serotonin receptor 2C; HTR1C; 5HT-1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-HT2C receptor; 5-HT2C; 5-HT1C; 5-HT-2C; 5-HT-1C
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Representative Drug(s) Ziprasidone Drug Info Ki = 0.55 nM Click to Show More [14]
2 Risperidone Drug Info IC50 = 1.81 nM [30]
3 Olanzapine Drug Info Ki = 2.8 nM [14]
4 Aripiprazole Drug Info Ki = 22 nM [8]
5 Chlorpromazine Drug Info Ki = 27 nM [60]
6 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name Adrenergic receptor alpha-1A (ADRA1A) Successful Target
UniProt ID ADA1A_HUMAN
Gene Name ADRA1A
Synonyms
Alpha-adrenergic receptor 1c; Alpha-1C adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1A adrenergic receptor; Alpha adrenergic receptor 1c; Alpha 1A-adrenoreceptor; Alpha 1A-adrenoceptor; ADRA1C
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Representative Drug(s) Phentolamine Drug Info Ki = 0.6 nM Click to Show More [15]
2 Risperidone Drug Info Ki = 2.8 nM [36]
3 Phenylephrine Drug Info EC50 = 55 nM [68]
4 Olanzapine Drug Info Ki = 60 nM [69]
5 Naphazoline Drug Info EC50 = 63.1 nM [70]
6 Aripiprazole Drug Info Ki = 100 nM [54]
7 Quetiapine Drug Info Ki = 100 nM [54]
Co-Target Name Carbonic anhydrase VI (CA-VI) Successful Target
UniProt ID CAH6_HUMAN
Gene Name CA6
Synonyms
Secreted carbonic anhydrase; Salivary carbonic anhydrase; Carbonic anhydrase 6; Carbonate dehydratase VI
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Representative Drug(s) Sulpiride Drug Info Ki = 0.8 nM [17]
Co-Target Name Adrenergic receptor alpha-1B (ADRA1B) Successful Target
UniProt ID ADA1B_HUMAN
Gene Name ADRA1B
Synonyms
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor; Alpha-1B adrenergic receptor; Alpha 1B-adrenoreceptor; Alpha 1B-adrenoceptor
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Representative Drug(s) Phenylephrine Drug Info EC50 = 0.86 nM Click to Show More [21]
2 Phentolamine Drug Info Ki = 4.8 nM [15]
3 Risperidone Drug Info Ki = 10 nM [54]
4 Aripiprazole Drug Info Ki = 100 nM [54]
5 Quetiapine Drug Info Ki = 100 nM [54]
6 Olanzapine Drug Info Ki = 1000 nM [54]
Co-Target Name Histamine H1 receptor (H1R) Successful Target
UniProt ID HRH1_HUMAN
Gene Name HRH1
Synonyms
HH1R; H1R
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Representative Drug(s) Chlorprothixene Drug Info IC50 = 1 nM Click to Show More [23]
2 Olanzapine Drug Info Ki = 1.2 nM [25]
3 Risperidone Drug Info Ki = 2.6 nM [35]
4 Chlorpromazine Drug Info Ki = 4.25 nM [43]
5 Ziprasidone Drug Info Ki = 5.3 nM [35]
6 Quetiapine Drug Info Ki = 8.7 nM [52]
7 Aripiprazole Drug Info Ki = 25.1 nM [10]
8 Haloperidol Drug Info Ki = 440 nM [52]
Co-Target Name Adrenergic receptor alpha-2A (ADRA2A) Successful Target
UniProt ID ADA2A_HUMAN
Gene Name ADRA2A
Synonyms
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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Representative Drug(s) Phentolamine Drug Info Ki = 1.7 nM Click to Show More [28]
2 Risperidone Drug Info Ki = 10 nM [25]
3 Pramipexole Drug Info Ki = 75.7 nM [67]
4 Aripiprazole Drug Info Ki = 100 nM [54]
5 Olanzapine Drug Info Ki = 192 nM [25]
6 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name Dopamine D5 receptor (D5R) Successful Target
UniProt ID DRD5_HUMAN
Gene Name DRD5
Synonyms
Dopamine receptor 5; DRD5; D1beta dopamine receptor; D(5)D(1B) dopamine receptor dopamine receptor; D(5) dopamine receptor
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Representative Drug(s) Dopamine Drug Info EC50 = 2 nM Click to Show More [31]
2 Chlorprothixene Drug Info Ki = 9 nM [43]
3 Haloperidol Drug Info Ki = 38 nM [65]
4 Olanzapine Drug Info Ki = 90 nM [57]
5 Chlorpromazine Drug Info Ki = 172 nM [43]
6 Phenyltoloxamine Drug Info Ki = 414 nM [90]
7 Risperidone Drug Info Ki = 1000 nM [54]
8 Aripiprazole Drug Info Ki ~ 1000 nM [54]
9 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name Muscarinic acetylcholine receptor M1 (CHRM1) Successful Target
UniProt ID ACM1_HUMAN
Gene Name CHRM1
Synonyms
M1 receptor
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Representative Drug(s) Olanzapine Drug Info Ki = 2.1 nM Click to Show More [14]
2 Quetiapine Drug Info Ki = 56 nM [14]
3 Chlorpromazine Drug Info Ki = 125.89 nM [27]
4 Risperidone Drug Info Ki ~ 1000 nM [54]
5 Aripiprazole Drug Info Ki ~ 1000 nM [54]
Co-Target Name Adrenergic receptor alpha-2C (ADRA2C) Successful Target
UniProt ID ADA2C_HUMAN
Gene Name ADRA2C
Synonyms
Subtype C4; Alpha-2CAR; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; ADRA2RL2; ADRA2L2
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Representative Drug(s) Naphazoline Drug Info Ki = 2.291 nM Click to Show More [32]
2 Risperidone Drug Info Ki = 3.2 nM [25]
3 Phentolamine Drug Info Ki = 8.4 nM [51]
4 Pramipexole Drug Info Ki = 52.2 nM [67]
5 Olanzapine Drug Info Ki = 82 nM [25]
6 Aripiprazole Drug Info Ki = 100 nM [54]
7 Quetiapine Drug Info Ki = 100 nM [54]
Co-Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target
UniProt ID KCNH2_HUMAN
Gene Name KCNH2
Synonyms
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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Representative Drug(s) Pimozide Drug Info IC50 = 3.02 nM Click to Show More [38]
2 Haloperidol Drug Info IC50 = 10 nM [39]
3 Droperidol Drug Info IC50 = 32.2 nM [62]
4 Thioridazine Drug Info IC50 = 33 nM [64]
5 Domperidone Drug Info IC50 = 57.54 nM [38]
6 Ziprasidone Drug Info IC50 = 120.23 nM [79]
7 Pergolide Drug Info IC50 = 120.23 nM [80]
8 Risperidone Drug Info IC50 = 147.91 nM [80]
9 Olanzapine Drug Info IC50 = 181 nM [82]
10 Mesoridazine Drug Info IC50 = 316.23 nM [80]
11 Aripiprazole Drug Info Ki = 598 nM [94]
Co-Target Name Dopamine D1 receptor (D1R) Successful Target
UniProt ID DRD1_HUMAN
Gene Name DRD1
Synonyms
D(1A) dopamine receptor
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Representative Drug(s) Apomorphine Drug Info EC50 = 3.77 nM Click to Show More [41]
2 Haloperidol Drug Info Ki = 6.166 nM [49]
3 Ziprasidone Drug Info Ki = 9.5 nM [14]
4 Olanzapine Drug Info Ki = 10 nM [14]
5 Chlorprothixene Drug Info Ki = 18 nM [43]
6 Dopamine Drug Info EC50 = 20 nM [58]
7 Risperidone Drug Info Ki = 21 nM [14]
8 Lisuride Drug Info Ki = 77 nM [74]
9 Chlorpromazine Drug Info Ki = 96 nM [43]
10 Aripiprazole Drug Info Ki = 310 nM [88]
11 Phenyltoloxamine Drug Info Ki = 343 nM [90]
12 Quetiapine Drug Info Ki = 390 nM [14]
Co-Target Name Carbonic anhydrase XII (CA-XII) Successful Target
UniProt ID CAH12_HUMAN
Gene Name CA12
Synonyms
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) Sulpiride Drug Info Ki = 3.9 nM [42]
Co-Target Name 5-HT 3A receptor (HTR3A) Successful Target
UniProt ID 5HT3A_HUMAN
Gene Name HTR3A
Synonyms
Serotonin-gated ion channel receptor; Serotonin receptor 3A; HTR3; 5HT3R; 5-hydroxytryptamine receptor 3A; 5-HT3RA; 5-HT3A; 5-HT3-A; 5-HT 3A
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Representative Drug(s) Sarizotan Drug Info IC50 < 6 nM Click to Show More [48]
2 Risperidone Drug Info Ki ~ 1000 nM [54]
3 Aripiprazole Drug Info Ki = 1000 nM [54]
4 Quetiapine Drug Info Ki ~ 1000 nM [54]
5 Olanzapine Drug Info Ki = 1000 nM [54]
Co-Target Name Norepinephrine transporter (NET) Successful Target
UniProt ID SC6A2_HUMAN
Gene Name SLC6A2
Synonyms
Solute carrier family 6 member 2; Sodium-dependent noradrenaline transporter; SLC6A2; NET1; NET; NAT1
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Representative Drug(s) Dopamine Drug Info IC50 = 6.63 nM [50]
Co-Target Name Adrenergic receptor alpha-1D (ADRA1D) Successful Target
UniProt ID ADA1D_HUMAN
Gene Name ADRA1D
Synonyms
Alpha-adrenergic receptor 1a; Alpha-1D adrenoreceptor; Alpha-1D adrenoceptor; Alpha-1D adrenergic receptor; Alpha adrenergic receptor 1a; Alpha 1D-adrenoreceptor; Alpha 1D-adrenoceptor; ADRA1A
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Representative Drug(s) Phentolamine Drug Info Ki = 7.6 nM [15]
Co-Target Name Adrenergic receptor alpha-2B (ADRA2B) Successful Target
UniProt ID ADA2B_HUMAN
Gene Name ADRA2B
Synonyms
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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Representative Drug(s) Phentolamine Drug Info Ki = 7.6 nM Click to Show More [51]
2 Pramipexole Drug Info Ki = 67.7 nM [67]
3 Olanzapine Drug Info Ki = 100 nM [54]
4 Risperidone Drug Info Ki = 1000 nM [54]
5 Aripiprazole Drug Info Ki = 1000 nM [54]
6 Quetiapine Drug Info Ki = 1000 nM [54]
Co-Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target
UniProt ID CDK4_HUMAN
Gene Name CDK4
Synonyms
PSK-J3; Cell division protein kinase 4
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Representative Drug(s) Palbociclib Drug Info IC50 = 9 nM [53]
Co-Target Name Muscarinic acetylcholine receptor M5 (CHRM5) Successful Target
UniProt ID ACM5_HUMAN
Gene Name CHRM5
Synonyms
CHRM5
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Representative Drug(s) Olanzapine Drug Info Ki = 10 nM Click to Show More [54]
2 Risperidone Drug Info Ki ~ 1000 nM [54]
3 Aripiprazole Drug Info Ki ~ 1000 nM [54]
4 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name 5-HT 1B receptor (HTR1B) Successful Target
UniProt ID 5HT1B_HUMAN
Gene Name HTR1B
Synonyms
Serotonin receptor 1B; Serotonin 1D beta receptor; S12; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT1B receptor; 5-HT1B; 5-HT-1D-beta; 5-HT-1B
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Representative Drug(s) Risperidone Drug Info Ki = 10 nM Click to Show More [54]
2 Aripiprazole Drug Info Ki = 1000 nM [54]
3 Quetiapine Drug Info Ki ~ 1000 nM [54]
4 Olanzapine Drug Info Ki = 1000 nM [54]
Co-Target Name 5-HT 2 receptor (5HT2R) Successful Target
UniProt ID 5HT2A_HUMAN; 5HT2B_HUMAN; 5HT2C_HUMAN
Gene Name NO-GeName
Synonyms
Serotonin receptor 2; 5-hydroxytryptamine receptor 2; 5-HT2 receptor
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Representative Drug(s) Olanzapine Drug Info Ki = 10 nM Click to Show More [55]
2 Haloperidol Drug Info Ki = 16 nM [56]
3 Quetiapine Drug Info Ki = 220 nM [86]
Co-Target Name Muscarinic acetylcholine receptor M4 (CHRM4) Successful Target
UniProt ID ACM4_HUMAN
Gene Name CHRM4
Synonyms
M4 receptor; CHRM4
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Representative Drug(s) Olanzapine Drug Info Ki = 12.59 nM Click to Show More [27]
2 Quetiapine Drug Info Ki = 125.89 nM [27]
3 Chlorpromazine Drug Info Ki = 158.49 nM [27]
4 Risperidone Drug Info Ki ~ 1000 nM [54]
5 Aripiprazole Drug Info Ki ~ 1000 nM [54]
Co-Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target
UniProt ID CDK6_HUMAN
Gene Name CDK6
Synonyms
Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
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Representative Drug(s) Palbociclib Drug Info IC50 = 15 nM [53]
Co-Target Name Muscarinic acetylcholine receptor (CHRM) Successful Target
UniProt ID ACM1_HUMAN; ACM2_HUMAN; ACM3_HUMAN; ACM4_HUMAN; ACM5_HUMAN
Gene Name NO-GeName
Representative Drug(s) Olanzapine Drug Info Ki = 26 nM [35]
Co-Target Name Serotonin transporter (SERT) Successful Target
UniProt ID SC6A4_HUMAN
Gene Name SLC6A4
Synonyms
Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter
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Representative Drug(s) Aripiprazole Drug Info Ki = 31.62 nM Click to Show More [27]
2 Ziprasidone Drug Info Ki = 53 nM [52]
3 Chlorpromazine Drug Info Ki = 63.1 nM [27]
Co-Target Name Aldehyde oxidase (AOX1) Successful Target
UniProt ID AOXA_HUMAN
Gene Name AOX1
Synonyms
AOX1
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Representative Drug(s) Perphenazine Drug Info IC50 = 33 nM Click to Show More [63]
2 Chlorpromazine Drug Info IC50 = 570 nM [63]
Co-Target Name Carbonic anhydrase II (CA-II) Successful Target
UniProt ID CAH2_HUMAN
Gene Name CA2
Synonyms
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) Sulpiride Drug Info IC50 = 40 nM [66]
Co-Target Name Janus kinase 3 (JAK-3) Successful Target
UniProt ID JAK3_HUMAN
Gene Name JAK3
Synonyms
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
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Representative Drug(s) Palbociclib Drug Info IC50 = 63.1 nM [71]
Co-Target Name Muscarinic acetylcholine receptor M2 (CHRM2) Successful Target
UniProt ID ACM2_HUMAN
Gene Name CHRM2
Synonyms
M2 receptor; CHRM2
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Representative Drug(s) Olanzapine Drug Info Ki = 100 nM Click to Show More [54]
2 Risperidone Drug Info Ki ~ 1000 nM [54]
3 Aripiprazole Drug Info Ki ~ 1000 nM [54]
4 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name Muscarinic acetylcholine receptor M3 (CHRM3) Successful Target
UniProt ID ACM3_HUMAN
Gene Name CHRM3
Synonyms
M3 receptor; CHRM3
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Representative Drug(s) Olanzapine Drug Info Ki = 100 nM Click to Show More [54]
2 Risperidone Drug Info Ki ~ 1000 nM [54]
3 Aripiprazole Drug Info Ki ~ 1000 nM [54]
4 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name 5-HT 1D receptor (HTR1D) Successful Target
UniProt ID 5HT1D_HUMAN
Gene Name HTR1D
Synonyms
Serotonin receptor 1D; Serotonin 1D alpha receptor; HTRL; HTR1DA; 5HT1D; 5-hydroxytryptamine receptor 1D; 5-HT1D receptor; 5-HT1D; 5-HT-1D-alpha; 5-HT-1D
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Representative Drug(s) Aripiprazole Drug Info Ki = 100 nM Click to Show More [54]
2 Risperidone Drug Info Ki = 1000 nM [54]
3 Quetiapine Drug Info Ki ~ 1000 nM [54]
4 Olanzapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name Human immunodeficiency virus Protease (HIV PR) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV PR
Synonyms
HIV Retropepsin; HIV PR
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Representative Drug(s) Haloperidol Drug Info Ki = 100 nM [76]
Co-Target Name Debrisoquine 4-hydroxylase (CYP2D6) Successful Target
UniProt ID CP2D6_HUMAN
Gene Name CYP2D6
Synonyms
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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Representative Drug(s) Perphenazine Drug Info IC50 = 120 nM Click to Show More [78]
2 Metoclopramide Drug Info Ki = 960 nM [99]
Co-Target Name Voltage-gated L-type calcium channel (L-CaC) Successful Target
UniProt ID CAC1C_HUMAN; CAC1D_HUMAN; CAC1F_HUMAN; CAC1S_HUMAN
Gene Name NO-GeName
Synonyms
L-type voltage-dependent Ca(2+) channel; L-type Ca2+ channel; L-type Ca(2+) channel
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Representative Drug(s) Pimozide Drug Info IC50 = 162 nM [64]
Co-Target Name 5-HT 3 receptor (5HT3R) Successful Target
UniProt ID 5HT3A_HUMAN; 5HT3B_HUMAN; 5HT3C_HUMAN; 5HT3D_HUMAN; 5HT3E_HUMAN
Gene Name NO-GeName
Synonyms
5-hydroxytryptamine receptor type 3; 5-hydroxytryptamine receptor 3; 5-HT3R; 5-HT3 receptor; 5-HT-3
    Click to Show/Hide
Representative Drug(s) Olanzapine Drug Info Ki = 199.53 nM Click to Show More [27]
2 Ziprasidone Drug Info Ki = 398.11 nM [27]
3 Aripiprazole Drug Info Ki = 501.19 nM [27]
Co-Target Name Multidrug resistance protein 1 (ABCB1) Clinical trial Target
UniProt ID MDR1_HUMAN
Gene Name ABCB1
Synonyms
PGY1; P-glycoprotein 1; MDR1; CD243 antigen; CD243; ATP-binding cassette sub-family B member 1
    Click to Show/Hide
Representative Drug(s) Haloperidol Drug Info Ki = 200 nM Click to Show More [84]
2 Chlorpromazine Drug Info Ki = 600 nM [84]
3 Aripiprazole Drug Info IC50 = 780 nM [96]
4 Pimozide Drug Info IC50 = 800 nM [98]
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
    Click to Show/Hide
Representative Drug(s) Phenylephrine Drug Info IC50 ~ 200 ug.mL-1 [85]
Co-Target Name Strychnine-binding glycine receptor (GLRA1) Successful Target
UniProt ID GLRA1_HUMAN
Gene Name GLRA1
Synonyms
Strychnine-insensitive glycine receptor; Strychnine binding subunit; Glycine receptor 48 kDa subunit; GLRA1
    Click to Show/Hide
Representative Drug(s) Risperidone Drug Info EC50 = 320 nM [89]
Co-Target Name Opioid receptor mu (MOP) Successful Target
UniProt ID OPRM_HUMAN
Gene Name OPRM1
Synonyms
hMOP; Mu-type opioid receptor; Mu opioid receptor; Mu opiate receptor; MOR1A; MOR1; MOR-1; M-OR-1
    Click to Show/Hide
Representative Drug(s) Pimozide Drug Info IC50 = 372 nM [91]
Co-Target Name Dopamine transporter (DAT) Successful Target
UniProt ID SC6A3_HUMAN
Gene Name SLC6A3
Synonyms
Solute carrier family 6 member 3; Sodium-dependent dopamine transporter; DAT1; DAT; DA transporter
    Click to Show/Hide
Representative Drug(s) Dopamine Drug Info IC50 = 460 nM [50]
Co-Target Name 5-HT 4 receptor (HTR4) Successful Target
UniProt ID 5HT4R_HUMAN
Gene Name HTR4
Synonyms
Serotonin receptor 4; 5-hydroxytryptamine receptor 4; 5-HT4 receptor; 5-HT4; 5-HT-4
    Click to Show/Hide
Representative Drug(s) Metoclopramide Drug Info EC50 = 794.33 nM [97]
Co-Target Name Opioid receptor kappa (OPRK1) Successful Target
UniProt ID OPRK_HUMAN
Gene Name OPRK1
Synonyms
OPRK; Kappa-type opioid receptor; Kappa opioid receptor; KOR-1; KOR; K-OR-1
    Click to Show/Hide
Representative Drug(s) Pimozide Drug Info IC50 = 990 nM [91]
Co-Target Name 5-HT 1E receptor (HTR1E) Successful Target
UniProt ID 5HT1E_HUMAN
Gene Name HTR1E
Synonyms
Serotonin receptor 1E; S31; 5-hydroxytryptamine receptor 1E; 5-HT1E; 5-HT-1E; 5-HT 1E
    Click to Show/Hide
Representative Drug(s) Risperidone Drug Info Ki ~ 1000 nM Click to Show More [54]
2 Aripiprazole Drug Info Ki ~ 1000 nM [54]
3 Quetiapine Drug Info Ki ~ 1000 nM [54]
4 Olanzapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name 5-HT 5A receptor (HTR5A) Successful Target
UniProt ID 5HT5A_HUMAN
Gene Name HTR5A
Synonyms
Serotonin receptor 5A; 5-hydroxytryptamine receptor 5A; 5-HT5A; 5-HT-5A; 5-HT-5; 5-HT 5A
    Click to Show/Hide
Representative Drug(s) Risperidone Drug Info Ki = 1000 nM Click to Show More [54]
2 Aripiprazole Drug Info Ki = 1000 nM [54]
3 Quetiapine Drug Info Ki ~ 1000 nM [54]
4 Olanzapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name 5-HT 7 receptor (HTR7) Clinical trial Target
UniProt ID 5HT7R_HUMAN
Gene Name HTR7
Synonyms
Serotonin receptor 7; 5HT7; 5-hydroxytryptamine receptor 7; 5-HT7 receptor; 5-HT7; 5-HT-X; 5-HT-7
    Click to Show/Hide
Representative Drug(s) Risperidone Drug Info Ki = 0.4 nM Click to Show More [100]
2 OPC-34712 Drug Info Ki = 3.7 nM [6]
3 Ziprasidone Drug Info Ki = 5 nM [100]
4 Aripiprazole Drug Info Ki = 10.3 nM [10]
5 Chlorpromazine Drug Info Ki = 10.72 nM [103]
6 Perphenazine Drug Info Ki = 23 nM [101]
7 Amisulpride Drug Info Ki = 25.12 nM [27]
8 Quetiapine Drug Info Ki = 63.1 nM [27]
9 Thioridazine Drug Info Ki = 70 nM [101]
10 Olanzapine Drug Info Ki = 79.43 nM [27]
11 Cariprazine Drug Info Ki = 111 nM [6]
12 Molindone Drug Info Ki = 265 nM [101]
13 Haloperidol Drug Info Ki = 316.23 nM [27]
Co-Target Name 5-HT 6 receptor (HTR6) Clinical trial Target
UniProt ID 5HT6R_HUMAN
Gene Name HTR6
Synonyms
Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6
    Click to Show/Hide
Representative Drug(s) Chlorprothixene Drug Info Ki = 3 nM Click to Show More [101]
2 Chlorpromazine Drug Info Ki = 4 nM [101]
3 Olanzapine Drug Info Ki = 5 nM [102]
4 Loxapine Drug Info Ki = 15 nM [101]
5 Ziprasidone Drug Info Ki = 20 nM [100]
6 Bromocriptine Drug Info Ki < 50 nM [106]
7 Pimozide Drug Info Ki = 71 nM [101]
8 Aripiprazole Drug Info Ki = 89 nM [100]
9 Zuclopenthixol Drug Info Ki = 169 nM [107]
10 Risperidone Drug Info Ki = 224 nM [110]
11 Quetiapine Drug Info Ki ~ 1000 nM [54]
Co-Target Name Sigma intracellular receptor 2 (TMEM97) Clinical trial Target
UniProt ID SGMR2_HUMAN
Gene Name TMEM97
Synonyms
Transmembrane protein 97; Sigma2 receptor; Sigma-2 receptor; Meningioma-associated protein 30; MAC30
    Click to Show/Hide
Representative Drug(s) Haloperidol Drug Info Ki = 16 nM [104]
Co-Target Name Carbonic anhydrase IX (CA-IX) Clinical trial Target
UniProt ID CAH9_HUMAN
Gene Name CA9
Synonyms
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
    Click to Show/Hide
Representative Drug(s) Sulpiride Drug Info Ki = 31 nM [105]
Co-Target Name Cholestenol delta-isomerase (EBP) Clinical trial Target
UniProt ID EBP_HUMAN
Gene Name EBP
Synonyms
Emopamilbinding protein; EBP; Delta(8)Delta(7) sterol isomerase; D8D7 sterol isomerase; 3betahydroxysteroidDelta(8),Delta(7)isomerase
    Click to Show/Hide
Representative Drug(s) Haloperidol Drug Info Ki = 190 nM [9]
Co-Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target
UniProt ID MDM2_HUMAN
Gene Name MDM2
Synonyms
RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
    Click to Show/Hide
Representative Drug(s) Apomorphine Drug Info IC50 = 195 nM [108]
Co-Target Name Histamine H4 receptor (H4R) Clinical trial Target
UniProt ID HRH4_HUMAN
Gene Name HRH4
Synonyms
SP9144; Pfi-013; HH4R; H4 receptor; GPRv53; GPCR105; G protein-coupled receptor 105; AXOR35
    Click to Show/Hide
Representative Drug(s) Loxapine Drug Info EC50 = 218.78 nM [109]
Co-Target Name Myeloperoxidase (MPO) Clinical trial Target
UniProt ID PERM_HUMAN
Gene Name MPO
Synonyms
MPO
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Representative Drug(s) Metoclopramide Drug Info IC50 = 350 nM [111]
Co-Target Name Positive transcription elongation factor b (P-TEFb) Clinical trial Target
UniProt ID CDK9_HUMAN-CCNT1_HUMAN
Gene Name CDK9-CCNT1
Synonyms
P-TEFb
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Representative Drug(s) Palbociclib Drug Info Ki = 364 nM [112]
Co-Target Name Nociceptin receptor (OPRL1) Clinical trial Target
UniProt ID OPRX_HUMAN
Gene Name OPRL1
Synonyms
Orphanin FQ receptor; Opioid-receptor-like 1; Opioid receptor like-1 receptor; Opioid receptor 4; ORL-1 receptor; ORL-1; OPRL1; OP(4); Kappa-type 3 opioid receptor; KOR-3
    Click to Show/Hide
Representative Drug(s) Fluspirilene Drug Info Ki = 500 nM [113]
Co-Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target
UniProt ID CDK9_HUMAN
Gene Name CDK9
Synonyms
Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2L4; CDC2-related kinase; C-2K
    Click to Show/Hide
Representative Drug(s) Palbociclib Drug Info IC50 = 794.33 nM [71]
Co-Target Name Histamine H3 receptor (H3R) Clinical trial Target
UniProt ID HRH3_HUMAN
Gene Name HRH3
Synonyms
Histamine receptor 3; HH3R; GPCR97; G-protein coupled receptor 97; G protein-coupled receptor 97
    Click to Show/Hide
Representative Drug(s) Chlorpromazine Drug Info Ki ~ 1000 nM Click to Show More [43]
2 Chlorprothixene Drug Info Ki ~ 1000 nM [43]
Co-Target Name Carbonic anhydrase VII (CA-VII) Patented-recorded Target
UniProt ID CAH7_HUMAN
Gene Name CA7
Synonyms
Carbonic anhydrase 7; Carbonate dehydratase VII
    Click to Show/Hide
Representative Drug(s) Sulpiride Drug Info Ki = 3.6 nM [114]
Co-Target Name HUAMN alpha-1 adrenergic receptor (ADRA1) Literature-reported Target
UniProt ID ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN
Gene Name ADRA1A; ADRA1B; ADRA1D
Synonyms
Alpha-1 adrenoreceptor
    Click to Show/Hide
Representative Drug(s) Risperidone Drug Info Ki = 0.69 nM Click to Show More [14]
2 Ziprasidone Drug Info Ki = 1.9 nM [14]
3 Quetiapine Drug Info Ki = 4.5 nM [14]
4 Haloperidol Drug Info Ki = 5.7 nM [115]
5 Olanzapine Drug Info Ki = 7.3 nM [14]
Co-Target Name Imidazoline receptor 1 (IR1) Literature-reported Target
UniProt ID NISCH_HUMAN
Gene Name NISCH
Synonyms
hIRAS; KIAA0975; Imidazoline-1 receptor candidate protein; Imidazoline-1 receptor; Imidazoline receptor antisera-selected protein; IRAS; IR1; I1R candidate protein; I-1 receptor candidate protein; I-1
    Click to Show/Hide
Representative Drug(s) Phentolamine Drug Info Ki = 11.4 nM Click to Show More [116]
2 Naphazoline Drug Info Ki = 121.6 nM [116]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D1 complex (CDK4-CCND1) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN
Gene Name CDK4-CCND1
Representative Drug(s) Palbociclib Drug Info IC50 = 2 nM [117]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D1 complex (CDK6-CCND1) Co-Target
UniProt ID CDK6_HUMAN-CCND1_HUMAN
Gene Name CDK6-CCND1
Representative Drug(s) Palbociclib Drug Info IC50 = 3.76 nM [118]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D2 complex (CDK6-CCND2) Co-Target
UniProt ID CDK6_HUMAN-CCND2_HUMAN
Gene Name CDK6-CCND2
Representative Drug(s) Palbociclib Drug Info IC50 = 9 nM [119]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D complex (CDK4-CCND) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN/CCND2_HUMAN/CCND3_HUMAN
Gene Name CDK4-CCND1-CCND2/CCND3
Representative Drug(s) Palbociclib Drug Info IC50 = 11 nM [120]
Co-Target Name Carbonic anhydrase VB (CA5B) Co-Target
UniProt ID CAH5B_HUMAN
Gene Name CA5B
Synonyms
Carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA-VB
    Click to Show/Hide
Representative Drug(s) Sulpiride Drug Info Ki = 18 nM [121]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D3 complex (CDK6-CCND2) Co-Target
UniProt ID CDK6_HUMAN-CCND3_HUMAN
Gene Name CDK6-CCND3
Representative Drug(s) Palbociclib Drug Info IC50 = 19 nM [122]
Co-Target Name Sodium channel alpha subunit Co-Target
UniProt ID SCN1A_HUMAN; SCN2A_HUMAN; SCN3A_HUMAN; SCN4A_HUMAN; SCN5A_HUMAN; SCN7A_HUMAN; SCN8A_HUMAN; SCN9A_HUMAN; SCNAA_HUMAN; SCNBA_HUMAN
Gene Name NO-GeName
Representative Drug(s) Pimozide Drug Info IC50 = 54 nM [64]
Co-Target Name Carbonic anhydrase VA (CA5A) Co-Target
UniProt ID CAH5A_HUMAN
Gene Name CA5A
Synonyms
Carbonic anhydrase 5A, mitochondrial; Carbonate dehydratase VA; CA-VA
    Click to Show/Hide
Representative Drug(s) Sulpiride Drug Info Ki = 174 nM [121]
Co-Target Name Cyclin dependent kinase 2-Cyclin A2 complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA2_HUMAN
Gene Name CDK2-CCNA2
Representative Drug(s) Palbociclib Drug Info IC50 = 230 nM [118]
Co-Target Name Glutamate [NMDA] receptor Co-Target
UniProt ID NMDE1_HUMAN; NMDE2_HUMAN; NMDE3_HUMAN; NMD3A_HUMAN; NMD3B_HUMAN; NMDE4_HUMAN; NMDZ1_HUMAN
Gene Name NO-GeName
Representative Drug(s) Chlorpromazine Drug Info IC50 = 600 nM [123]
Co-Target Name Brain sodium channel alpha (Types I, II, III) Co-Target
UniProt ID SCN1A_HUMAN; SCN2A_HUMAN; SCN3A_HUMAN
Gene Name SCN1A; SCN2A; SCN3A
Representative Drug(s) Droperidol Drug Info IC50 = 740 nM [124]
References  Top
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