miRNA General Information
miRNA Mature ID hsa-miR-96-5p
miRNA Stemloop AC MI0000098
miRNA Stemloop ID hsa-mir-96
Sequence uuuggcacuagcacauuuuugcu
TTD Target(s) Regulated by This miRNA ALK tyrosine kinase receptor (ALK) Successful Target Target Info [1]
5-HT 1B receptor (HTR1B) Successful Target Target Info [2]
Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Target Info [3]
Brain-derived neurotrophic factor (BDNF) Clinical trial Target Target Info [4]
Glial cell line-derived neurotrophic factor (GDNF) Clinical trial Target Target Info [5]
Protein arginine methyltransferase 5 (PRMT5) Clinical trial Target Target Info [6]
Isoleucyl-tRNA synthetase (IARS) Literature-reported Target Target Info [7]
DNA repair protein RAD51 homolog 1 (RAD51) Clinical trial Target Target Info [8]
Forkhead box protein O1A (FOXO1) Literature-reported Target Target Info [9]
Excitatory amino acid transporter 3 (SLC1A1) Literature-reported Target Target Info [10]
Insulin receptor substrate-1 (IRS1) Clinical trial Target Target Info [11]
Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Target Info [12]
Scavenger receptor class B member 1 (SCARB1) Literature-reported Target Target Info [13]
Suppressor of tumorigenicity 15 protein (ST15) Literature-reported Target Target Info [14]
Protein(s) Regulated by This miRNA Adenylate cyclase type 6 Regulated Protein [15]
DNA repair protein REV1 Regulated Protein [8]
Forkhead box protein O3 Regulated Protein [17]
Forkhead box protein O3 Regulated Protein [18]
Metalloproteinase inhibitor 1 Regulated Protein [19]
Metastasis suppressor protein 1 Regulated Protein [20]
Microphthalmia-associated transcription factor Regulated Protein [15]
Sodium- and chloride-dependent taurine transporter Regulated Protein [10]
Tribbles homolog 3 Regulated Protein [22]
Tumor protein p53-inducible nuclear protein 1 Regulated Protein [17]
Tyrosine-protein phosphatase non-receptor type 9 Regulated Protein [23]
Zinc finger E-box-binding homeobox 1 Regulated Protein [24]
Zinc finger protein SNAI2 Regulated Protein [24]
References
REF 1 MicroRNA 96 is a post-transcriptional suppressor of anaplastic lymphoma kinase expression. Am J Pathol. 2012 May;180(5):1772-80.
REF 2 A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Mol Psychiatry. 2009 Apr;14(4):381-9.
REF 3 Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the -Catenin/TCF/LEF-1 pathway in gastric cancer cells. Nucleic Acids Res. 2014 Mar;42(5):2988-98.
REF 4 Brain-derived neurotrophic factor is a novel target gene of the has-miR-183/96/182 cluster in retinal pigment epithelial cells following visible light exposure. Mol Med Rep. 2015 Aug;12(2):2793-9.
REF 5 GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function. PLoS Genet. 2015 Dec 17;11(12):e1005710.
REF 6 Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol Cell Biol. 2008 Oct;28(20):6262-77.
REF 7 The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational repression of IRS-1 in SK-Hep1 cells. Biochem Biophys Res Commun. 2013 May 10;434(3):503-8.
REF 8 MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition. Cancer Res. 2012 Aug 15;72(16):4037-46.
REF 9 Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009 Aug 28;284(35):23204-16.
REF 10 Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Eur J Neurosci. 2014 Mar;39(6):1026-41.
REF 11 Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem. 2007 Nov 9;282(45):32582-90.
REF 12 Upregulation of microRNA-96 and its oncogenic functions by targeting CDKN1A in bladder cancer. Cancer Cell Int. 2015 Nov 14;15:107.
REF 13 MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition. Mol Cell Biol. 2013 May;33(10):1956-64.
REF 14 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 15 MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster.J Biol Chem. 2007 Aug 24;282(34):25053-66.
REF 16 MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition. Cancer Res. 2012 Aug 15;72(16):4037-46.
REF 17 MicroRNA-96 promotes the proliferation of colorectal cancer cells and targets tumor protein p53 inducible nuclear protein 1, forkhead box protein O1 (FOXO1) and FOXO3a. Mol Med Rep. 2015 Feb;11(2):1200-6.
REF 18 Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a.PLoS One. 2010 Dec 23;5(12):e15797.
REF 19 ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.Exp Mol Med. 2016 Mar 25;48:e222.
REF 20 Calcium channel blockers in myocardial infarction.Arch Intern Med. 1989 Jul;149(7):1669-77. Review
REF 21 Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Eur J Neurosci. 2014 Mar;39(6):1026-41.
REF 22 Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation.J Cell Biochem. 2014 May;115(5):889-95.
REF 23 miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.Sci Rep. 2016 Nov 18;6:37421.
REF 24 A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.Mol Cell Biol. 2014 Feb;34(3):533-50.

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