Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00140 | Target Info | |||
| Target Name | Arachidonate 5-lipoxygenase (5-LOX) | ||||
| Synonyms |
LOG5; 5-lipoxygenase; 5-LO
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | ALOX5 | ||||
| Biochemical Class | Oxygenase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 135 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ketotifen
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Ketotifene; Ketotifeno; Ketotifenum; Ketotifin; Ketotiphen; Ketotiphene; Zaditor; Ketotifene fumarate; Alaway (TN); HC 20-511; Ketotifen (INN); Ketotifen [INN:BAN]; Ketotifene [INN-French]; Ketotifeno [INN-Spanish]; Ketotifenum [INN-Latin]; Zaditor (TN); 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1); 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one; 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one; 4-(1-Methyl-4-piperidylidene)-9-hydrobenzo[a]thiopheno[3,2-d][7]annulen-10-one; 4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thia-benzo[f]azulen-10-one; 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
SCOPOLETIN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
scopoletin; 92-61-5; Gelseminic acid; 6-Methylesculetin; 7-Hydroxy-6-methoxy-2H-chromen-2-one; Chrysatropic acid; Scopoletine; 7-Hydroxy-6-methoxycoumarin; Scopoletol; Murrayetin; 6-O-Methylesculetin; Escopoletin; 6-Methoxy-7-hydroxycoumarin; 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one; 6-Methoxyumbelliferone; 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-; Esculetin 6-methyl ether; beta-Methylesculetin; Esculetin-6-methyl ether; .beta.-Methylesculetin; Buxuletin; UNII-KLF1HS0SXJ; COUMARIN, 7-HYDROXY-6-METHOXY-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
ISOSCOPOLETIN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isoscopoletin; 776-86-3; 6-Hydroxy-7-methoxycoumarin; 6-hydroxy-7-methoxy-2H-chromen-2-one; 7-Methoxyesculetin; Isoscopoletine; 6-hydroxy-7-methoxychromen-2-one; 2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-; 6-hydroxy-7-methoxy-chromen-2-one; CHEMBL390320; CHEBI:81484; iso-scopoletin; 6-Hydroxy-7-methoxy-2-benzopyrone; EINECS 212-282-4; AC1L2CWN; Esculetin 7-methyl ether; Esculetin, 7-methyl ether; AC1Q4EZ0; 6-Hydroxy-7-methylcoumarin; SCHEMBL2790887; AC1Q69W0; CTK7A0381; DTXSID40228266; MolPort-003-927-047
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
tryptanthrin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GNF-PF-2691; couroupitine a
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[3] | |||
| Compound Name |
5-(Methylamino)-2-naphthalen-1-yl-1,3-thiazole-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3262925; NCGC00319032-01; SCHEMBL16515732; BDBM50011783
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(2-Methylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288314; ZINC4359575; BDBM50017557; STK751777; AKOS001600259; MCULE-8641465654; EU-0001575; ST51018485; 3-[(2-methylphenyl)amino]-6-nitrobenzo[d]1,2-thiazoline-1,1-dione; N-(2-methylphenyl)-6-nitro-1,2-benzisothiazol-3-amine 1,1-dioxide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
12-Oxo-ETE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
12-OxoETE; (5Z,8Z,10E,14Z)-12-Oxoicosa-5,8,10,14-tetraenoic acid; 12-KETE; 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid; CHEMBL3310737; (5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoic acid; (5Z,8Z,10E,14Z)-12-Oxoicosa-5,8,10,14-tetraenoate; 12-keto-ETE; C14807; SCHEMBL21114414; Eicosanoids_12-oxoETE_C20H30O3; 1176AH; BDBM50045523; LMFA03060019; ZINC14953043; 12-oxo, 5c,8c,10t,14c-20:4; SR-01000946927; SR-01000946927-1; Q27115848; (5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoate; 5,8,10,14-Eicosatetraenoicacid,12-oxo-,(5Z,8Z,10E,14Z)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-[(3-Bromophenyl)methyl]-6-nitro-1,1-dioxo-1,2-benzothiazol-3-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288312; BDBM50017555
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(Benzyloxycarbonyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238472; 3-[benzyloxycarbonyl]benzoic acid; isophthalic acid benzyl ester; SCHEMBL181934; Isophthalic acid 1-benzyl ester; isophthalic acid mono-benzyl ester; 3-phenylmethoxycarbonylbenzoic acid; BDBM50004449; ZINC13376021; AKOS024287950; MCULE-5962096621; DA-15380; ST51045755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(Phenylcarbamoyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238475; 3-carboxybenzanilide; SCHEMBL11474161; ZINC3013960; BDBM50004445; AKOS009497310; Z928188008
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-(3,4-Dichlorophenyl)-5-(methylamino)-1,3-oxazole-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3262909; SCHEMBL16515745; BDBM50011736; NCGC00262512-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(3,4-Dimethoxyphenyl)-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238469; Oprea1_416233; ZINC3093771; BDBM50004430; MFCD00751156; STK208060; AKOS002955561; MCULE-3580047724
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3,5-Dinitro-benzoic acid biphenyl-4-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238212; Oprea1_197694; Oprea1_874389; biphenyl-4-yl 3,5-dinitrobenzoate; 4-phenylphenyl 3,5-dinitrobenzoate; ZINC1807859; BDBM50004447; STK362678; AKOS001377405; MCULE-8807971556; [1,1'-Biphenyl]-4-yl 3,5-dinitrobenzoate; ST45157763; [1,1'-Biphenyl]-4-yl 3,5-dinitrobenzoate #; Z30252263
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2,3-Dichlorophenyl 3,5-dinitrobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238210; ZINC3149168; BDBM50004446; STK444341; AKOS003323448; MCULE-3361553327; ST50847623
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-Fluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271116; MLS002607766; SCHEMBL1531886; BDBM50329324; NCGC00185051-01; SMR001522640; Q27164160; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 3-fluorobenzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ML351; ML 351; MLS000082299; 5-(methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile; 5-(methylamino)-2-(naphthalen-1-yl)-1,3-oxazole-4-carbonitrile; 5-Methylamino-2-naphthalen-1-yl-oxazole-4-carbonitrile; 5-(Methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile; SMR000045344; MLS004813835; cid_664510; CHEMBL1548353; SCHEMBL16515652; BDBM79800; GTPL10263; HMS2156P03; HMS3313H01; REGID_FOR_CID_664510; ZINC542135; MFCD04183120; STK905505; AKOS005183681; MCULE-5030858957; NCGC00070329-02; NCGC00070329-03; ML351, >=98% (HPLC); ST45252961; A1-18402; 2-(1-Naphthyl)-5-(methylamino)oxazole-4-carbonitrile; 5-(methylamino)-2-(1-naphthyl)oxazole-4-carbonitrile; 5-(methylamino)-2-naphthyl-1,3-oxazole-4-carbonitrile; Z1213743771; 5-(methylamino)-2-(1-naphthyl)-1,3-oxazol-4-yl cyanide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Meso-3,3'-Didemethoxynectandrin B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147417; 4-epi-larreatricin; 4-epilarreatricin; BDBM50391885; Q27137586; 4,4'-[(2R,3R,4S,5S)-3,4-dimethyloxolane-2,5-diyl]diphenol; 4,4'-(3beta,4beta-Dimethyltetrahydrofuran-2alpha,5alpha-diyl)bis(phenol); 4-[(2S,3S,4R,5R)-5-(4-hydroxyphenyl)-3,4-dimethyl-tetrahydrofuran-2-yl]phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Rataniaphenol III
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147423; Ratanhiaphenol III; SCHEMBL15259393; BDBM50391880; Q27137592; 2-(2-methoxy-4-hydroxyphenyl)-5-(E)-propenylbenzofuran; 3-methoxy-4-{5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl}phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-(3-Chlorophenyl)-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238466; C13H8ClN3O5; Oprea1_470663; ZINC3152018; BDBM50004428; MFCD00407957; STK899823; AKOS001437599; MCULE-7650820611; ST50563539; (3,5-dinitrophenyl)-N-(3-chlorophenyl)carboxamide; F1018-0052
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[(2S,3R)-3-(Hydroxymethyl)-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147418; BDBM50391888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
2-(4-Hydroxyphenyl)-5-(E)-propenylbenzofuran
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147422; BDBM50391887; 4-[5-(1-Propenyl)benzofuran-2-yl]phenol; 4-[5-[(E)-1-Propenyl]benzofuran-2-yl]phenol; Q27137591; 4-{5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl}phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-(3-Chlorophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288308; CBMicro_007157; SMSF0012572; ZINC4372951; BBL025006; BDBM50017531; MFCD00486315; STL287095; AKOS001702327; CB09537; MCULE-9482519103; BIM-0007234.P001; H6268; ST51018490; 3-[(3-chlorophenyl)amino]-6-nitrobenzo[d]1,2-thiazoline-1,1-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
7-Tert-butyl-3,3-dimethyl-N-propyl-2H-1-benzofuran-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122065; BDBM50066556; 7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-carboxylic acid propylamide; N-propyl (7-tert-butyl-3,3-dimethyl-2,3-dihydrobenzo[b]furan-5-yl)carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
6-Nitro-1,1-dioxo-N-quinolin-5-yl-1,2-benzothiazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288319; BDBM50017562
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(3-Bromophenyl)-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238467; ZINC5428012; BDBM50004448; MFCD01010633; AKOS002948764
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-Cyclopropyl-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119170; BDBM50066565; 7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-carboxylic acid cyclopropylamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
2-(2,4-Dihydroxyphenyl)-5-(e)-propenylbenzofuran
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147420; BDBM50391890; 2-(2,4-Dihydroxyphenyl)-5- (E)-propenylbenzofuran; Q27137589; 4-[5-[(E)-1-Propenyl]benzofuran-2-yl]-1,3-benzenediol; 4-{5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl}benzene-1,3-diol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-(3-Methylphenyl)-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238465; 3,5-dinitro-N-(3-methylphenyl)benzamide; Oprea1_102748; ARONIS001551; KS-00003UZN; ZINC3151015; BDBM50004426; MFCD00403536; STK023146; AKOS000491189; MCULE-1198336138; ST45038367; N~1~-(3-methylphenyl)-3,5-dinitrobenzamide; AG-205/05882010; (3,5-dinitrophenyl)-N-(3-methylphenyl)carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
1-[5-Chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PF-4693627; CHEMBL2325079; PF 4693627; SCHEMBL2031399; BDBM50426967; ZINC72315303; NCGC00386681-01; NCGC00386681-02; HY-125415; CS-0091336; PF 04693627
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(2,3-Dichlorophenyl)-5-(methylamino)-1,3-oxazole-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3262908; SCHEMBL16516282; BDBM50011735; NCGC00262519-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-[2,2'']Bipyridinyl-6-yl-[1,2,4]triazinan-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126949; BDBM50053459; ZINC13759120
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
3-Naphthalen-1-yloxycarbonylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238473; SCHEMBL15153930; BDBM50004443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(-)-Larreatricin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147416; BDBM50391882; Q27137584; 4,4'-[(2S,3R,4S,5S)-3,4-dimethyloxolane-2,5-diyl]diphenol; 4,4'-[(3beta,4beta-Dimethyltetrahydrofuran)-2alpha,5beta-diyl]bisphenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Eupomatenoid 6
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Rataniaphenol II; CHEMBL463574; Eupomatenoid-6; Ratanhiaphenol II; Eupomatenoid VI; Eupamatenoid 6; Rhataniaphenol II; SCHEMBL748016; 2-(4-Hydroxyphenyl)-3-methyl-5-(E)-propenylbenzofuran; BDBM50391884; NCGC00160183-01; Q27137594; 4-[3-methyl-5-[(E)-prop-1-enyl]benzofuran-2-yl]phenol; Phenol, 4-(2-methyl-5-(1E)-1-propenyl-2-benzofuranyl)-; Phenol, 4-(3-methyl-5-(1-propenyl)-2-benzofuranyl)-, (E)-; 4-{3-methyl-5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl}phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
3,5-Dinitro-N-(3-phenylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238471; BDBM50004427
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-(5-Bromonaphthalen-1-yl)-6-nitro-1,1-dioxo-1,2-benzothiazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288320; BDBM50017563
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N1-Naphthyl-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238463; ZINC3107339; BDBM50004424; MFCD00376801; AKOS000643005; N-(1-Naphthyl)-3,5-dinitrobenzamide; MCULE-6235141774; (3,5-dinitrophenyl)-N-naphthylcarboxamide; N-(naphthalen-1-yl)-3,5-dinitrobenzamide; ST50238617; SR-01000356208; SR-01000356208-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Rataniaphenol I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147424; Ratanhiaphenol I; Phenol, 5-methoxy-2-(5-(1E)-1-propenyl-2-benzofuranyl)-; BDBM50391883; Q27137593; 2-(2-hydroxy-4-methoxyphenyl)-5-(E)-propenylbenzofuran; 5-methoxy-2-{5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl}phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
3-(Naphthalen-1-ylcarbamoyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238474; BDBM50004444
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-(2-Methoxyethyl)-7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419947; BDBM50066564; 7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-carboxylic acid (2-methoxy-ethyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
N'-Phenylbutanehydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26851; N'-phenylbutanohydrazide; SCHEMBL1531522; N'-Phenylbutyric acid hydrazide; Butyric acid N'-phenyl-hydrazide; Butyric acid N''-phenyl-hydrazide; ZINC3845669; BDBM50280193; STL572731; AKOS004905622
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[13] | |||
| Compound Name |
1-(3-Hydroxymethyl-phenyl)-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281981; SCHEMBL9645755; BDBM50280179; EU-0042733; SR-01000076363; SR-01000076363-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[13] | |||
| Compound Name |
Chembl4281021
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468670
Click to Show/Hide
|
||||
| Activity |
IC50 = 54300 nM
|
[14] | |||
| Compound Name |
[2-[3-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]-(2,4,6-trichlorophenyl)methanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163221
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[15] | |||
| Compound Name |
1-o-Tolyl-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281259; SCHEMBL9645318; BDBM50280200
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[13] | |||
| Compound Name |
[2-[3-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]-(4-fluorophenyl)methanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163243
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[15] | |||
| Compound Name |
(4-Chlorophenyl)-[2-[3-[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]methanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163219
Click to Show/Hide
|
||||
| Activity |
IC50 = 59300 nM
|
[15] | |||
| Compound Name |
Chembl4292720
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468642
Click to Show/Hide
|
||||
| Activity |
IC50 = 59500 nM
|
[14] | |||
| Compound Name |
(4-Bromophenyl)-[2-[3-[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]methanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1164396
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[15] | |||
| Compound Name |
4-[(4-Methylsulfanylphenyl)methoxy]-1-(3-nitrophenyl)but-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929094; BDBM50359869
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[16] | |||
| Compound Name |
1-Acetyl-2-phenylhydrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N'-Phenylacetohydrazide; Acetylphenylhydrazine; Acetic acid, 2-phenylhydrazide; Hydracetin; Pyrodin; Pyrodine; N-Acetyl-N'-phenylhydrazine; N'-Phenylacethydrazide; beta-Acetylphenylhydrazine; Acetic acid phenylhydrazone; 1-Phenyl-2-acetylhydrazine; N(1)-Acetylphenylhydrazine; .beta.-Acetylphenylhydrazine; NSC 2064; Fenylhydrazid kyseliny octove; UNII-C818L19FMP; N-Acetylphenylhydrazine; N-(phenylamino)acetamide; 1-ACETYL-2-PHENYL HYDRAZIDE; 2-Acetyl-1-phenylhydrazine; CHEMBL30131; C818L19FMP; MFCD00008672; WLN: 1VMMR; 2'-Phenylacetohydrazide; CCRIS 4569; HSDB 7235; EINECS 204-055-3; Fenylhydrazid kyseliny octove [Czech]; BRN 0742880; 2-Phenylhydrazide acetic acid; AI3-01560; Acetic phenylhydrazide; PubChem7620; acetyl phenyl hydrazine; N-Acetoylphenylhydrazone; DSSTox_CID_15; N'-Phenylacetohydrazide #; N-Acetyl-N-phenylhydrazine; ACMC-1C00O; DSSTox_RID_75322; 1-acetyl-2-phenyl hydrazine; 1-acetyl-2-phenyl-hydrazine; DSSTox_GSID_20015; KSC490O5D; SCHEMBL425872; N'-phenyl-acetic acid hydrazide; Acetic acid N'-phenyl-hydrazide; DTXSID1020015; CTK3J0751; UICBCXONCUFSOI-UHFFFAOYSA-; NSC2064; NSC2847; Acetic acid N''-phenyl-hydrazide; ZINC156602; KS-00000WS9; NSC-2064; NSC-2847; Tox21_200069; ANW-16717; BDBM50280201; NSC229032; SBB058004; STK400328; 1-Acetyl-2-phenylhydrazine, >=98%; AKOS000119811; CS-W018141; MCULE-5989143063; NSC-229032; VZ21080; NCGC00090860-01; NCGC00090860-02; NCGC00257623-01; AK164410; AS-12891; A0107; FT-0629848; ST45139305; K-1060; Q2806574; W-108597
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[13] | |||
| Compound Name |
3-(3-Bromophenyl)-N-[1-(4-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-4,5-dihydro-5-isoxazolecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165869; CBKinase1_008368; CBKinase1_020768; AN-329/43211400; BDBM50394756; STK341185; AKOS003364004; AKOS022070647; MCULE-7036059231; ST50636633; BRD-A13623050-001-01-8
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[17] | |||
| Compound Name |
4-(3-Tetradeca-1,3,5,8-tetraenyl-thiiranyl)-butyric acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348933; BDBM50027527
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[18] | |||
| Compound Name |
2-(Furan-2-yl)-1H-1,3-benzodiazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Furan-2-yl-1H-benzoimidazol-5-ylamine; CHEMBL3099590; 2-(furan-2-yl)-1H-benzo[d]imidazol-5-amine; 2-(2-furyl)-1H-benzimidazol-5-amine; 2-(furan-2-yl)-3H-benzimidazol-5-amine; Oprea1_861532; SCHEMBL4239794; SCHEMBL10758216; CTK7D8509; CTK8F3649; ZINC184648; 5-Amino-2-(2-furyl)benzimidazole; BDBM50444537; AKOS000191586; MCULE-7294538293; NE37082; 2-furan-2-yl-1 h-benzoimidazol-5-ylamine; DB-103475; EU-0076627; EN300-49835; 1H-Benzimidazol-5-amine,2-(2-furanyl)-(9CI); AE-848/30744050; Z600397732
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[19] | |||
| Compound Name |
[2-[3-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]-phenylmethanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163237
Click to Show/Hide
|
||||
| Activity |
IC50 = 66400 nM
|
[15] | |||
| Compound Name |
4-Chloro-3-nitro-N-(9H-xanthen-9-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165868; ZINC01022274; Oprea1_765693; CBDivE_010073; ZINC1022274; BDBM50394755; STK388150; AKOS003646326; MCULE-8765590628; ST45057456; (4-chloro-3-nitrophenyl)-N-xanthen-9-ylcarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[17] | |||
| Compound Name |
4-((1-Hydroxy-6-oxo-1,6-dihydropyridin-3-yl)ethynyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512897; BDBM50243740; 1-(4-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[20] | |||
| Compound Name |
(5E)-5-(5-Chloro-2-hydroxy-3-methoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165866; ZINC1008682; BDBM50394754; STK152814; AKOS000335689; AN-698/42006703; 5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[17] | |||
| Compound Name |
1-(2,3-Dimethoxyphenyl)-4-[(4-methylsulfanylphenyl)methoxy]but-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929089; BDBM50359864
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[16] | |||
| Compound Name |
2-(1,3-Benzothiazol-2-yl)-4-[1-[(3,4-dichlorophenyl)methylamino]ethylidene]-5-(trifluoromethyl)pyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165865; AK-968/12167906; SCHEMBL15250735; SCHEMBL16552831; ZINC8431459; BDBM50394752; STK957599; AKOS003792701; ZINC100095407; MCULE-5998234561
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[17] | |||
| Compound Name |
6-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165867; ZINC8393280; BDBM50394753; STK242363; AKOS003380447; MCULE-1376317711; AO-365/43368620; 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(phenylthio)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[17] | |||
| Compound Name |
Potassium;2-[[4-(3,7-dimethyloctoxy)phenyl]methoxy]-6-hydroxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3094153
Click to Show/Hide
|
||||
| Activity |
Ki = 70300 nM
|
[21] | |||
| Compound Name |
4-[(4-Methylsulfanylphenyl)methoxy]-1-(2,3,4-trimethoxyphenyl)but-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929090; BDBM50359865
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[16] | |||
| Compound Name |
Chembl4287970
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468681
Click to Show/Hide
|
||||
| Activity |
IC50 = 74300 nM
|
[22] | |||
| Compound Name |
2,5-Dihydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
gentisic acid; Benzoic acid, 2,5-dihydroxy-; Hydroquinonecarboxylic acid; Gentisate; 5-Hydroxysalicylic acid; Gensigen; Gensigon; 2,5-Dioxybenzoic acid; 2,5-Dhba; Gentisinic acid; Salicylic acid, 5-hydroxy-; Kyselina gentisinova; Gentisinate; UNII-VP36V95O3T; MFCD00002460; NSC 27224; Kyselina 2,5-dihydroxybenzoova; 3,6-dihydroxybenzoic acid; 2,5-Dihydroxy benzoic acid; CHEMBL1461; VP36V95O3T; BENZOIC ACID,2,5-DIHYDROXY; Gentinatre; Gentalpin; Gentasol; Gentidol; Gentisan; Gentisod; Legential; Nagentis; Casate; Gabail; Nagent; Carboxyhydroquinone; Casate sodium; Gensalate sodium; Sodium-Gent; WLN: QVR BQ EQ; GENTISATE SODIUM; 2,5-Dihydroxybenzoic acid, 99%; Acido gentisico; Acide gentisique; Acidum gentisicum; Kyselina gentisinova [Czech]; NSC8512; Acide gentisique [INN-French]; Acido gentisico [INN-Spanish]; Acidum gentisicum [INN-Latin]; Gentisic acid [INN]; EINECS 207-718-5; Acido 2,5-diidrossibenzoico [Italian]; BRN 2209119; Kyselina 2,5-dihydroxybenzoova [Czech]; Acido 2,5-diidrossibenzoico; AI3-60431; Dihydroxybenzoicacid; 2,5-Dioxybenzoate; GENOP; 5-hydroxy-Salicylate; Mesalamine Impurity G; 3,6-Dihydroxybenzoate; Gentisinic acid polymer; PubChem14414; Spectrum_001241; 2,5dihydroxybenzoic acid; 5-hydroxy-Salicylic acid; Spectrum2_000773; Spectrum3_001326; Spectrum4_001821; Spectrum5_000581; 2,5-DihydroxybenzoicAcid; ACMC-1AP4E; 2,5,dihydroxybenzoic acid; bmse000326; SCHEMBL3690; 2,5-dihydroxy-benzoic acid; 2,5-Dihydroxybenzoate, VI; NCIOpen2_000913; Oprea1_039290; BSPBio_003051; KBioGR_002487; KBioSS_001721; 4-10-00-01441 (Beilstein Handbook Reference); KSC236E9L; MLS002207134; Benzoicacid, 2,5-dihydroxy-; DivK1c_000538; SPBio_000846; ZINC1507; DTXSID4060078; CTK1D6295; HMS501K20; KBio1_000538; KBio2_001721; KBio2_004289; KBio2_006857; KBio3_002271; KS-00000COX; NINDS_000538; 2,5-Dihydroxybenzoic acid, 98%; NSC27224; NSC49098; ANW-30725; BBL013232; BDBM50335808; CCG-40154; NSC-27224; NSC-49098; s3799; SBB058777; STK426343; AKOS003267857; AS04641; CS-W001179; HY-W001179; MCULE-7171470745; PS-6232; VZ22769; IDI1_000538; NCGC00178325-01; AC-23625; AK-49825; SC-46608; SMR000393742; SY014321; gentisic acid (2,5-dihydroxybenzoic acid); DB-051598; D0569; D2933; FT-0610382; FT-0667079; ST50824443; EN300-81715; 2,5-Dihydroxybenzoic acid, analytical standard; C00628; K-9198; AE-562/40605400; Q417831; W-106033; 26A2CD0F-7EBD-431F-8BDA-168766205AE1; Z275164274
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[23] | |||
| Compound Name |
4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl benzo[b]thiophene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270810; SCHEMBL1531989; BDBM50329322; NCGC00185053; NCGC00185053-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[8] | |||
| Compound Name |
4-{[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}but-2-yn-1-yl 4-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270608; MLS002607777; SCHEMBL1531857; BBL019158; BDBM50329329; MFCD07039044; STL140809; ZINC36381526; AKOS005715806; MCULE-6985006049; NCGC00185064-01; SMR001522651; H4992; AP-853/43261189; Q27164848; 4-(5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl4-Fluorobenzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[8] | |||
| Compound Name |
2-{3-Nitro-5-[(4-methylphenyl)sulfanyl]-1H-1,2,4-triazol-1-yl}-1-phenylethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163383; ZINC1134801; BDBM50394772; STK877922; AKOS003405261; MCULE-2848210363; AP-853/41543842; 2-{5-[(4-methylphenyl)sulfanyl]-3-nitro-1H-1,2,4-triazol-1-yl}-1-phenylethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[17] | |||
| Compound Name |
2-[3-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-5-[(4-methylsulfonylphenyl)methyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163223
Click to Show/Hide
|
||||
| Activity |
IC50 = 76600 nM
|
[15] | |||
| Compound Name |
Chembl4285912
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468679
Click to Show/Hide
|
||||
| Activity |
IC50 = 77600 nM
|
[22] | |||
| Compound Name |
1-(4-Chloro-phenyl)-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283419; SCHEMBL9645256; BDBM50280186
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[13] | |||
| Compound Name |
1-(3,4-Dimethoxyphenyl)-4-[(4-methylsulfanylphenyl)methoxy]but-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929091; BDBM50359866
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[16] | |||
| Compound Name |
4-[(4-Methylsulfanylphenyl)methoxy]-1-(3,4,5-trimethoxyphenyl)but-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929092; BDBM50359867
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[16] | |||
| Compound Name |
4-(4-Chlorobenzylidene)-2-(2-naphthyl)-1,3-oxazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165863; ZINC4471754; BDBM50394751; AKOS003831257; ST50983055; AG-690/37078004; 4-[(4-chlorophenyl)methylene]-2-(2-naphthyl)-1,3-oxazolin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[17] | |||
| Compound Name |
(1E,6E)-1,7-Bis[4-hydroxy-3-methoxy-5-(3-methylbutyl)phenyl]hepta-1,6-diene-3,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290440; BDBM50020586
Click to Show/Hide
|
||||
| Activity |
IC50 = 80200 nM
|
[24] | |||
| Compound Name |
Tert-butyl N-[(3-nitrophenyl)sulfonylamino]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165864; SCHEMBL7105243; tert-butyl 2-({3-nitrophenyl}sulfonyl)hydrazinecarboxylate; ZINC4313579; BDBM50394750; AKOS000608880; MCULE-7543043929; AG-690/15431400; SR-01000315428; SR-01000315428-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[17] | |||
| Compound Name |
N'-[4-[2-[3-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indole-5-carbonyl]phenyl]sulfonyl-N,N-dimethylmethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163222
Click to Show/Hide
|
||||
| Activity |
IC50 = 81400 nM
|
[15] | |||
| Compound Name |
N-[2-({5-Nitro-2-furoyl}amino)ethyl]-2-quinolinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165862; BDBM50394749; STK708582; ZINC10313530; AKOS005529239; MCULE-9068417873; AO-365/43403215; N-(2-{[(5-nitrofuran-2-yl)carbonyl]amino}ethyl)quinoline-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[17] | |||
| Compound Name |
Chembl4291372
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468684
Click to Show/Hide
|
||||
| Activity |
IC50 = 82400 nM
|
[22] | |||
| Compound Name |
N-[(3-Bromophenyl)methyl]-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238470; BDBM50004453
Click to Show/Hide
|
||||
| Activity |
IC50 = 83600 nM
|
[7] | |||
| Compound Name |
8-Hydroxy-2-methyl-1-{2-[4-(4-methylpyridin-2-yl) piperazin-1-yl]ethyl}-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159099; SCHEMBL8553220; BDBM50036292
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[25] | |||
| Compound Name |
Methyl (5-methyl-4-phenyl-1,3-thiazol-2-yl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099678; Cambridge id 5704524; ZINC995592; BDBM50444533; STK448772; AKOS003254506; MCULE-5240197706; ST50916369; SR-01000217738; SR-01000217738-1; methoxy-N-(5-methyl-4-phenyl(1,3-thiazol-2-yl))carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[19] | |||
| Compound Name |
7-(4-Bromophenyl)-9,9-dioxo-7lambda4,9lambda6-dithia-8-azabicyclo[4.3.0]nona-1(6),2,4,7-tetraene-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1917107; BDBM50357353
Click to Show/Hide
|
||||
| Activity |
IC50 = 91100 nM
|
[26] | |||
| Compound Name |
[2-[3-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]propyl]-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]-phenylmethanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1164949
Click to Show/Hide
|
||||
| Activity |
IC50 = 92900 nM
|
[15] | |||
| Compound Name |
Chembl4277332
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468688
Click to Show/Hide
|
||||
| Activity |
IC50 = 95100 nM
|
[22] | |||
| Compound Name |
1-{[6-(2,3-Dihydro-1,4-benzodioxin-2-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-1,2,3-benzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000080901; MLS000051826; MLS002547988; CHEMBL1392167; BDBM34438; cid_2971957; HMS2437B19; STK506605; AKOS005454352; MCULE-5953341220; AO-365/43113231; SR-01000293136; SR-01000293136-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[17] | |||
| Compound Name |
Chembl4282135
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468674
Click to Show/Hide
|
||||
| Activity |
IC50 = 97500 nM
|
[14] | |||
| Compound Name |
1-(2-Chloro-phenyl)-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27410; SCHEMBL9645814; BDBM50280195
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[13] | |||
| Compound Name |
Methyl 4-[({[(2-phenyl-4-quinolinyl)carbonyl]amino}carbothioyl)amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1555743; MLS000324909; Oprea1_140747; REGID_for_CID_996799; ZINC650628; BDBM50394758; STK301462; AKOS003790973; MCULE-5696242907; SMR000159958; AK-968/41169732; methyl 4-({[(2-phenylquinolin-4-yl)carbonyl]carbamothioyl}amino)benzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Substituted chalcone, 5c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523655; BDBM29149; 4-Methoxy-2'-hydroxy-4'-(prenyloxy)chalcone; J3.547.663F
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2''-Hydroxy-2,3,4-trimethoxy-4''-O-prenylchalcone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215041; BDBM50324102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-Chloro-5-[5-({2-[(4-fluorophenyl)amino]-2-oxoethyl}sulfanyl)-1H-tetrazol-1-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163375; ZINC4581374; BDBM50394765; STL071321; AKOS001754865; MCULE-5392807484; ST065555
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
4-(2-Tetradecyl-cyclopropyl)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164332; BDBM50027526
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[18] | |||
| Compound Name |
Chembl4287548
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468700
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-Benzyl-6-(3,4-dichlorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165872; ZINC2180680; BDBM50394760; STK500078; AKOS003647162; MCULE-4076973859; AO-365/43113260
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-[(E)-{2-[(4-Chloro-1-methyl-1H-pyrazol-5-yl)carbonyl]hydrazinylidene}methyl]phenyl 4-nitrobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163378; BDBM50394768; STK165009; AKOS003983638; AK-968/40388353; 2-{2-[(4-chloro-1-methyl-1H-pyrazol-5-yl)carbonyl]carbohydrazonoyl}phenyl 4-nitrobenzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
15-Oxo-ETE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
15-OxoETE; 15-Kete; (5Z,8Z,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid; 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid; 15-ketoeicosatetraenoic acid; CHEMBL418941; 15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate; 15-Oxo-5,8,11-cis-13-trans-icosatetraenoate; Q50318261; 15-KETE (15-oxo-ETE); (5Z,8Z,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoate; C04577; 15-Ketoicosatetraenoic acid; BSPBio_001363; SCHEMBL144747; BML1-E01; HMS1361E05; HMS1791E05; HMS1989E05; HMS3402E05; ZINC4629855; 1234AH; BDBM50025735; LMFA03060051; IDI1_033833; NCGC00161270-01; NCGC00161270-02; NCGC00161270-03; 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoate; SR-01000946931; 15-Oxo-5,8,11-cis-13-trans-eicosatetraenoic acid; 15-Oxo-5,8,11-cis-13-trans-icosatetraenoic acid; SR-01000946931-1; (5Z,8Z,11Z,13E)-15-ketoeicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E)-15-oxo-5,8,11,13-eicosatetraenoic acid; (5Z,8Z,11Z,13E)-15-oxoeicosa-5,8,11,13-tetraenoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(1,3-Benzothiazol-2-yl)-4-[(2-hydroxy-3-methoxyphenyl)methylamino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ML355; ML355 free base; UNII-JKU4XCC48Y; ML-355; JKU4XCC48Y; CHEMBL3113165; NCGC00263773-03; GTPL8752; SCHEMBL16646023; BCP28954; EX-A1987; VLX-1005; BDBM50447175; ML 355; s6557; ML 355;ML-355; ZINC103266485; CS-3351; NCGC00263773-01; NCGC00263773-18; AK547442; BS-15552; HY-12341; B8014; Q27087172; N-(2-Benzothiazolyl)-4-(2-hydroxy-3-methoxybenzylamino)benzenesulfonamide; N-(benzo[d]thiazol-2-yl)-4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide; N-(Benzo[d]thiazol-2-yl)-4-(2-hydroxy-3-methoxybenzylamino)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Chembl4294783
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-(2-Benzoxazolyl)-4-(2-hydroxy-3-methoxybenzylamino)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3113166; SCHEMBL16646088; BDBM50447176; NCGC00345009-01; N-(1,3-benzoxazol-2-yl)-4-[(2-hydroxy-3-methoxyphenyl)methylamino]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Chembl4285779
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468690
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4295144
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468692
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4291296
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468680
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-Methyl-8-quinolyl 3-nitrobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163379; Oprea1_136888; Oprea1_438247; ZINC326421; BDBM50394770; AKOS000515810; MCULE-1799476303; ST50228614
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
3-(4-Methoxyphenyl)-6-[(E)-2-(2-methoxyphenyl)ethenyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163374; ZINC5345182; BDBM50394764; STK297995; AKOS003373972; AO-365/43301118; 3-(4-methoxyphenyl)-6-[2-(2-methoxyphenyl)vinyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
1-Phenyl-4-phenylmethoxybut-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929086; BDBM50359861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
1-(4-Methoxyphenyl)-4-[(4-methylsulfanylphenyl)methoxy]but-2-yn-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929088; BDBM50359863
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[(8-Hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000714362; SMR000274342; Oprea1_336993; Oprea1_793179; SCHEMBL2598266; CHEMBL1370513; BDBM65361; cid_3136123; HMS2691F18; AKOS000539049; NCGC00182903-03; SR-01000360535; SR-01000360535-1; N-[(8-hydroxy-7-quinolyl)-(2-thienyl)methyl]propionamide; N-[(8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]propanamide; N-[(8-oxidanylquinolin-7-yl)-thiophen-2-yl-methyl]propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
Chembl4290401
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468696
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000714585; SMR000274564; BAS 01923195; Oprea1_179687; Oprea1_779522; SCHEMBL609894; CHEMBL1405150; BDBM64651; cid_3136134; HMS2674N10; AKOS000539018; NCGC00182957-03; NCGC00182957-04; NCGC00188867-01; NCGC00188868-01; SR-01000361829; SR-01000361829-1; N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-thienyl)methyl]propanamide; N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-thienyl)methyl]propionamide; N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-thiophen-2-yl-methyl]propanamide; N-[(5-chloro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
1-[(4-Methylsulfanylphenyl)methoxy]non-2-yn-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929087; BDBM50359862
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Chembl4293801
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468685
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-Hydroxymethyl-icosa-6,8,11,14-tetraenoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL17775; BDBM50024435
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[18] | |||
| Compound Name |
N-[(5-Bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1573436; SMR001355490; MLS002729016; MLS003370621; SCHEMBL2598269; ML127; BDBM50350396; NCGC00183685-01; NCGC00183685-02; NCGC00183685-04; NCGC00188369-01; NCGC00188369-02; NCGC00188369-03; NCGC00188370-01; NCGC00188370-02; NCGC00188370-03; Q27163564; N-[(5-bromo-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
4-Methoxy-2'',4''-di-O-prenylchalcone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215044; BDBM50324105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-Methyl-2-[5-(2-methylphenyl)-1H-pyrazol-3-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000099089; SMR000070479; Oprea1_416132; Oprea1_488713; CHEMBL1488723; SCHEMBL10357282; BDBM56150; cid_5405417; ZINC13126656; AKOS000603258; MCULE-7146164517; J3.557.722J; 4-methyl-2-[5-(o-tolyl)-1H-pyrazol-3-yl]phenol; BRD-K22424638-001-08-4; 2-[5-(2-Methylphenyl)-1H-pyrazole-3-yl]-4-methylphenol; (6E)-4-methyl-6-[5-(o-tolyl)-3-pyrazolin-3-ylidene]cyclohexa-2,4-dien-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
2''-Hydroxy-2,3-dimethoxy-4''-O-prenylchalcone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1212962; BDBM50324101
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
13-Keto-9Z,11E-octadecadienoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(9Z,11E)-13-Oxooctadeca-9,11-dienoic acid; 13-OXO-ODE; 13-oxo-9Z,11E-ODE; 13-OxoODE; 13-KODE; 13-ketooctadecadienoic acid; CHEMBL1378466; 13-ketoODE; 13-Oxo-9Z,11E-octadecadienoic acid; (9Z,11E)-13-Oxooctadeca-9,11-dienoate; (E,Z)-13-Oxo-9,11-octadecadienoic acid; 9,11-Octadecadienoic acid, 13-oxo-, (E,Z)-; 13-Ketooctadecadienoioc acid; BSPBio_001333; BML1-E02; SCHEMBL2513742; HMS1791C15; HMS1989C15; HMS3402C15; ZINC4655398; 13-ketooctadeca-9,11-dienoic acid; Eicosanoids_13-oxoODE_C18H30O3; BDBM50045522; LMFA02000016; 13-Keto-octadeca-9Z,11E-dienoic acid; NCGC00161271-01; NCGC00161271-02; NCGC00161271-03; C14765; (9z,11e)-13-oxo-octadeca-9,11-dienoic acid; 9,11-Octadecadienoic acid, 13-oxo-, (9Z,11E)-; Q27104960
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-4-ethoxy-N-phenylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165874; ZINC637386; BDBM50394762; STK053910; AKOS000381163; MCULE-9625344119; AO-081/40778633; SR-01000498163; SR-01000498163-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TCMDC-123650; MLS000713956; SMR000273437; ChemDiv3_003931; Cambridge id 6955265; Oprea1_392575; Oprea1_876567; SCHEMBL609251; CHEMBL580727; BDBM64674; cid_2920571; HMS1484C15; HMS2626D19; CCG-21589; IDI1_021841; NCGC00179686-01; NCGC00179686-04; NCGC00179686-06; SJ000032162; SR-01000503652; SR-01000503652-1; BRD-A10105593-001-01-3; N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide; N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-furyl)methyl]propanamide; N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-furyl)methyl]propionamide; N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(furan-2-yl)methyl]propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(4Z)-2-(4-Chloro-3-nitrophenyl)-4-(2,3,4-trimethoxybenzylidene)-1,3-oxazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163373; HMS623O21; ZINC994313; BDBM50394763; STK839022; AKOS002092376; AK-968/11573163; SR-01000553134; SR-01000553134-1; (Z)-2-(4-chloro-3-nitrophenyl)-4-(2,3,4-trimethoxybenzylidene)oxazol-5(4H)-one; 2-{4-chloro-3-nitrophenyl}-4-(2,3,4-trimethoxybenzylidene)-1,3-oxazol-5(4H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Chembl4283450
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468691
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4286799
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468702
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2Z)-2-(4-Hydroxy-3-iodo-5-nitrobenzylidene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165873; ZINC8439234; BDBM50394761; STK161336; AKOS000596983; MCULE-5054044685; AG-205/37047027; SR-01000518643; SR-01000518643-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TCMDC-125548; CHEMBL528045; Cambridge id 6961519; Oprea1_670700; Oprea1_728804; SCHEMBL607837; BDBM50350394; CCG-21588; AKOS000538852; NCGC00183692-01; EU-0079950; SJ000032161; SR-01000503650; SR-01000503650-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
2''-Hydroxy-3,4,5-trimethoxy-4''-O-prenylchalcone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215043; BDBM50324104
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-(4-Chloro-2-methylphenyl)-2-(4-oxo-5,6,7,8-tetrahydro[1]benzothieno[2,3-d][1,2,3]triazin-3(4H)-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165871; ZINC646325; BDBM50394759; AKOS001680795; MCULE-2729457403; ST50200926; AP-906/42086948
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
4-{[5-(3-Chlorophenyl)-2-furyl]methylene}-2-(3-methylphenyl)-1,3-oxazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163376; ZINC4471787; BDBM50394766; AKOS000518801; ST50238722; AG-690/37128069; 4-{[5-(3-chlorophenyl)(2-furyl)]methylene}-2-(3-methylphenyl)-1,3-oxazolin-5-o ne
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2'-Hydroxy-3,4-dimethoxy-4'-(3-methyl-2-butenyloxy)chalcone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215042; BDBM50324103; 2''-Hydroxy-3,4-dimethoxy-4''-O-prenylchalcone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Chembl4282527
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Morusin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Mulberrochromene; TCMDC-124149; UNII-T4VGD5NP9B; NSC649220; T4VGD5NP9B; CHEMBL464006; Morusin, 3; NSC 649220; MLS000697591; MEGxp0_001039; SCHEMBL2562778; ACon1_001205; cid_5281671; DTXSID70211641; HMS2271K05; BCP16494; HY-N0622; ZINC5195808; BDBM50242014; LMPK12110912; MFCD09953814; AKOS032962066; CS-6885; NSC-649220; AK169967; SMR000470930; FT-0686661; N2266; W1523; A14647; C10106; BRD-K40169295-001-01-2; Q27107393
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
Chembl4283079
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
1-(4-Ethyl-phenyl)-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL29939; Oprea1_505010; SCHEMBL9645354; BDBM50280190
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[13] | |||
| Compound Name |
15-Oxo-puupehenoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1165243; BDBM50320453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[32] | |||
| Compound Name |
1-(4-Methoxy-phenyl)-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL29414; Oprea1_078411; SCHEMBL9645753; BDBM50280191
Click to Show/Hide
|
||||
| Activity |
IC50 = 156000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101230; 6-Methyl-8-mercaptochinolin; 8-Quinolinethiol, 6-methyl-; SCHEMBL18526845; BDBM50264491
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
4-[(2-Hydroxy-3-methoxyphenyl)methylamino]-N-(1,3-thiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1596118; SMR000072364; MLS000088134; SCHEMBL16646082; HMS2401E17; ZINC793995; BDBM50447178; STK806487; AKOS000505685; MCULE-3112730599; NCGC00059191-02; NCGC00059191-03; EU-0048240; MLS000088134-02; 4-[(2-hydroxy-3-methoxybenzyl)amino]-N-1,3-thiazol-2-ylbenzenesulfonamide; N-(2-Thiazolyl)-4-(2-hydroxy-3-methoxybenzylamino)benzenesulfonamide; 4-[(2-hydroxy-3-methoxybenzyl)amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide; 4-[[(2-Hydroxy-3-methoxyphenyl)methyl]amino]-N-2-thiazolyl-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[28] | |||
| Compound Name |
3-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100994; 8-Quinolinethiol, 3-methyl-; 3-methyl-8-quinolinethiol; SCHEMBL3067414; BDBM50264503
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
Atractylenolide II
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Atractylenolide; Asterolide; CHEMBL485805; Q63398440; 8,12-EPOXYEUDESMA-4(14),7(11)-DIEN-12-ONE; ATRACTYLENOLIDE 2; SCHEMBL19082785; HMS3886J22; HY-N0202; BDBM50241946; MFCD09037396; ZINC15207329; AKOS025119314; CCG-266807; CS-3670; N2205; S9314; X1091; C17886; 069A144; Q-100801
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[34] | |||
| Compound Name |
5-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Quinolinethiol, 5-methyl-; CHEMBL4084782; 5-methyl-8-quinolinethiol; SCHEMBL13977568; CTK1H9946; DTXSID70500764; BDBM50264484
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
Atractylenolide I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Atractylenolide-1; Atractylenolide 1; CHEMBL449520; Q63396593; 8,12-EPOXYEUDESMA-4(14),7(11),8-TRIEN-12-ONE; 8,9-dehydroasterolide; Atractylenolide-I; SCHEMBL1898423; HMS3886N08; HY-N0201; BDBM50241939; MFCD09037395; s8291; ZINC15207341; Atractylenolide I, >=98% (HPLC); AKOS025119313; CCG-266793; CCG-266794; CS-3669; N2541; X1093; C17885; 069A133; Q-100800
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[34] | |||
| Compound Name |
4-Methylquinoline-8-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Quinolinethiol, 4-methyl-; CHEMBL4063134; 4-methyl-8-quinolinethiol; SCHEMBL15703126; CTK0B7293; DTXSID80492580; BDBM50264490
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
Atractylenolide III
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Codonolactone; 8beta-Hydroxyasterolide; 8-Hydroxyasterolide; CHEMBL486961; AtractylenolideIII; MFCD00238543; 8,12-EPOXYEUDESMA-4(14),7(11)-DIEN-8-OL-12-ONE; Atractylenolide-III; HSDB 8108; Atractylenolide beta; Atractylodes japonica; ATRACTYLENOLIDE 3; SCHEMBL19082784; DTXSID50223308; BCP18761; HY-N0203; ZINC5373275; BDBM50241945; s9313; AKOS015897171; Atractylenolide III, >=98% (HPLC); CCG-266941; CS-3671; MCULE-9995877189; NCGC00385304-01; N2540; X1092; C17887; 030A714; Q-100798; Q27138303
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[34] | |||
| Compound Name |
8-Mercaptoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinoline-8-thiol; 8-Quinolinethiol; SQT-8; 8-thioquinoline; [S]c1cccc2cccnc12; 8-Mercaptoquinoline (8TQ); NCIOpen2_001790; SCHEMBL536578; CHEMBL4076575; DTXSID70197678; BDBM224013; HMS1788G22; ZINC389710; NSC48888; NSC-48888; AKOS022191814; AKOS024342879; MCULE-9204136169; DB-070965; FT-0735097; MLS-0472512.0001; 8-Quinolinethiol;Quinoline-8-thiol;8-Thioquinoline; F9994-0398
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
1-(2-Methoxy-phenyl)-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28579; BDBM50280194
Click to Show/Hide
|
||||
| Activity |
IC50 = 204000 nM
|
[13] | |||
| Compound Name |
7-Methoxy-2-(trifluoromethyl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4H-1-Benzopyran-4-one, 7-methoxy-2-(trifluoromethyl)-; 7-methoxy-2-(trifluoromethyl)chromen-4-one; CHEMBL3099591; 7-methoxy-2-trifluoromethylchromone; CDS1_004102; CBMicro_023686; MixCom6_000710; DivK1c_005142; CTK1E0617; DTXSID00357920; WT870; ZINC437880; BDBM50444536; CCG-10914; MFCD00760804; STK074790; AKOS001704383; DS-6436; MCULE-9210328196; KS-000001A4; AK114291; BIM-0023812.P001; X5672; Q-9355; SR-01000513684; SR-01000513684-1; 2-(Trifluoromethyl)-7-methoxy-4H-1-benzopyran-4-one; 578-84-7 7-methoxy-2-(trifluoromethyl)-4H-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 237000 nM
|
[19] | |||
| Compound Name |
1-p-Tolyl-tetrahydro-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432466; Oprea1_010424; SCHEMBL9645657; BDBM50280189
Click to Show/Hide
|
||||
| Activity |
IC50 = 277000 nM
|
[13] | |||
| Compound Name |
2-Heptyn-4-ol, 1-(phenylmethoxy)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929097; ACMC-20mtv0; 1-benzyloxy-2-heptyn-4-ol; 1-(Benzyloxy)hept-2-yn-4-ol; CTK0C1105; DTXSID60563686; BDBM50359860
Click to Show/Hide
|
||||
| Activity |
IC50 = 760000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides. J Med Chem. 1989 Mar;32(3):583-93. | ||||
| REF 2 | Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. | ||||
| REF 3 | Recent synthetic and medicinal perspectives of tryptanthrin. Bioorg Med Chem. 2017 Sep 1;25(17):4533-4552. | ||||
| REF 4 | Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014 May 22;57(10):4035-48. | ||||
| REF 5 | Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2764-7. | ||||
| REF 6 | Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. Bioorg Med Chem. 2014 Aug 1;22(15):4293-7. | ||||
| REF 7 | Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors. Bioorg Med Chem. 2014 Apr 15;22(8):2396-402. | ||||
| REF 8 | Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J Med Chem. 2010 Oct 28;53(20):7392-404. | ||||
| REF 9 | Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. J Nat Prod. 2011 Aug 26;74(8):1779-86. | ||||
| REF 10 | New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29. | ||||
| REF 11 | Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9. | ||||
| REF 12 | 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones. J Med Chem. 1996 Sep 27;39(20):3938-50. | ||||
| REF 13 | Structure-activity relationships of the pyridazinone series of 5-lipoxygenase inhibitors. Bioorg Med Chem Lett. 1992 Nov;2(11):1357-60. | ||||
| REF 14 | Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. Eur J Med Chem. 2018 Jul 15;155:946-960. | ||||
| REF 15 | Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24. | ||||
| REF 16 | Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors. Eur J Med Chem. 2012 Jan;47(1):351-9. | ||||
| REF 17 | Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. J Med Chem. 2012 Mar 22;55(6):2597-605. | ||||
| REF 18 | Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds. J Med Chem. 1983 Jan;26(1):72-8. | ||||
| REF 19 | Exploring the chemical space of multitarget ligands using aligned self-organizing maps. ACS Med Chem Lett. 2013 Oct 23;4(12):1169-72. | ||||
| REF 20 | Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4195-8. | ||||
| REF 21 | Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. Bioorg Med Chem. 2013 Dec 15;21(24):7763-78. | ||||
| REF 22 | Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease. Eur J Med Chem. 2018 Aug 5;156:534-553. | ||||
| REF 23 | Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54(2):591-602. | ||||
| REF 24 | SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem. 2014 Jul 10;57(13):5638-48. | ||||
| REF 25 | Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. J Med Chem. 1995 Feb 17;38(4):669-85. | ||||
| REF 26 | Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors. Bioorg Med Chem. 2011 Nov 1;19(21):6316-28. | ||||
| REF 27 | Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors. Bioorg Med Chem. 2010 Aug 15;18(16):5807-15. | ||||
| REF 28 | Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506. | ||||
| REF 29 | Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem. 2011 Aug 11;54(15):5485-97. | ||||
| REF 30 | A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem. 2016 Mar 15;24(6):1183-90. | ||||
| REF 31 | Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro. J Nat Prod. 2011 Apr 25;74(4):614-9. | ||||
| REF 32 | Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. | ||||
| REF 33 | Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem. 2017 Feb 23;60(4):1343-1361. | ||||
| REF 34 | 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. J Nat Prod. 1998 Mar;61(3):347-50. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.