Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13260 | Target Info | |||
| Target Name | Aromatase (CYP19A1) | ||||
| Synonyms |
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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| Target Type | Successful Target | ||||
| Gene Name | CYP19A1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 114 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
ABIRATERONE
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Approved | Compound Info | ||
| Synonyms |
Abiraterone (AR inhibitor)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Ketoconazole
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Approved | Compound Info | ||
| Synonyms |
KCZ; KTZ; K 1003; R 41400; R41400; KS-1205; KW-1414; Perkhotal (TN); R 41,400; R-41400; R41,400; Ketoconazole [USAN:INN:BAN:JAN]; Nizoral, Extina, Xolegel, Kuric, Ketoconazole; Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine; Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE; (+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine; (+/-)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine; (+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone; 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Genistein
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Phase 2/3 | Compound Info | ||
| Synonyms |
Bonistein; GEN; Genestein; Genisteol; Genisterin; Prunetol; Sophoricol; Differenol A; G 6649; G10000; IN1327; NPI 031L; STO514; TNP00151; GENISTEIN (ENDOCRINE DISRUPTER); Lactoferrin-genistein; PTI G4660 (Genistein); PTI-G4660; SIPI 807-1; C.I. 75610; SIPI-9764-I; ENDOCRINE DISRUPTOR (GENISTEIN) (SEE ALSO GENISTEIN (446-72-0)); 4 inverted exclamation marka,5,7-Trihydroxyisoflavone; ,5,7-Trihydroxyisoflavone; 4',5, 7-Trihydroxyisoflavone; 4',5,7-Trihydroxy isoflavone; 4',5,7-Trihydroxyisoflavone; 4,5,7-Trihydroxyiso-flavone; 4,6,7-Trihydroxyisoflavone; 5,7,4'-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
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| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
SB 206553
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Terminated | Compound Info | ||
| Synonyms |
SB 206553; 158942-04-2; SB-206553; Tocris-1661; CHEMBL297784; CHEBI:8977; UNII-AL4387525T; AL4387525T; SB-206,553; 1-methyl-N-pyridin-3-yl-6,7-dihydropyrrolo[2,3-f]indole-5-carboxamide; SB-206553 hydrochloride hydrate; SB206553; Lopac-S-180; AC1L1JQU; AC1Q5NRE; Lopac0_001163; GTPL189; SCHEMBL1459242; ZINC5994; DTXSID9043984; CTK8H1211; BDBM50060417; pyrrolo[2,3-f]indole-1(2h)-carboxamide, 3,5-dihydro-5-methyl-n-3-pyridinyl-; AKOS027381420; 5-Methyl-N-(3-pyridinyl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide; CCG-205237
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol
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Investigative | Compound Info | ||
| Synonyms |
Dihydroresveratrol; 58436-28-5; 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol; 3,4',5-Trihydroxybibenzyl; CHEMBL111234; CHEBI:4582; 5-(4-hydroxyphenethyl)benzene-1,3-diol; Dihydroresveratol; 3ftu; Dihydro-Resveratrol; RE2; a, b-Dihydroresveratrol; AC1L4HRG; C10255; 5-[2-(4-hydroxyphenyl)ethyl]-1,3-Benzenediol; 3,5,4'-trihydroxybibenzyl; 3,4'',5-trihydroxybibenzyl; 1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethyl)-; SCHEMBL716856; AC1Q79W7; CTK5A8302; MolPort-035-706-156; ZINC899123; LMPK13090035; BDBM50085531; NSC723534; AKOS030555676
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,3'-(1,2,4-thiadiazole-3,5-diyl)diphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503399; SCHEMBL12871356; BDBM25839; hydroxyphenyl substituted thiadiazole, 11
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
RG-50810
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Investigative | Compound Info | ||
| Synonyms |
Tyrphostin 23; 118409-57-7; Tyrphostin A23; AG 18; RG-50810; (3,4-Dihydroxybenzylidene)malononitrile; AG-18; Tyrphostin AG18; Tyrphostin RG50810; 2-(3,4-dihydroxybenzylidene)malononitrile; UNII-RV0GCD31OJ; alpha-Cyano-(3,4-dihydroxy)cinnamonitrile; 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile; RG 50810; Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]-; ag18; (3,4-Dihydroxyphenyl)methylene propanedinitrile; RV0GCD31OJ; C10H6N2O2; NCGC00016043-03; (3,4-dihydroxybenzylidene)propanedinitrile; DSSTox_CID_25215
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| Activity |
IC50 = 70600 nM
|
[5] | |||
| Compound Name |
6,8-Dimethoxy-4-methylquinolin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
casimiroin analogue, 1i; 2(1H)-Quinolinone, 6,8-dimethoxy-4-methyl-; CHEMBL476126; BDBM29220; MolPort-028-745-488; ZINC40429907; 249737-05-1
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| Activity |
IC50 ~ 91290 nM
|
[6] | |||
| Compound Name |
6-Methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
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Investigative | Compound Info | ||
| Synonyms |
6-Methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one; 6-Methyl[1,3]dioxolo[4,5-H]quinolin-8(9h)-One; 1137557-67-5; casimiroin analogue, 1a; CHEMBL482693; BDBM29212
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| Activity |
IC50 ~ 98490 nM
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[6] | |||
| Compound Name |
SB 242084
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Investigative | Compound Info | ||
| Synonyms |
SB-242,084; SB242084
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
SB 221284
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Investigative | Compound Info | ||
| Synonyms |
SB-221284; SB221284
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
daidzein
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Investigative | Compound Info | ||
| Synonyms |
Daidzein; 486-66-8; 4',7-Dihydroxyisoflavone; Daidzeol; 7,4'-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; UNII-6287WC5J2L; CCRIS 7600; K 251b; 4,7-Dihydroxyisoflavone; EINECS 207-635-4; BRN 0231523; CHEMBL8145; 4',7-Dihydroxy-iso-flavone; d-(+)-alpha-methylbenzylamine; ,7-Dihydroxyisoflavone; 7,4'-dihydroxyisoflavone; DIADZEIN
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| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
GALANGIN
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Investigative | Compound Info | ||
| Synonyms |
Galangin; 548-83-4; Norizalpinin; 3,5,7-Trihydroxyflavone; 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one; 3,5,7-triOH-Flavone; UNII-142FWE6ECS; 3,5,7-Trihydroxy-2-phenyl-4-benzopyrone; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-; EINECS 208-960-4; NSC407229; FLAVONE, 3,5,7-TRIHYDROXY-; NSC 407229; NSC-407229; 4H-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-; BRN 0272179; 142FWE6ECS; 3,5,7-trihydroxy-2-phenylchromen-4-one; CHEBI:5262; CHEMBL309490; VCCRNZQBSJXYJD-UHFFFAOYSA-N; 3,5,7-trihydroxy-2-phenyl-4H-benzopyran-4-one
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| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
1,4-Dimethylquinolin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
1,4-dimethylquinolin-2(1h)-one; 2584-47-6; 2(1H)-Quinolinone, 1,4-dimethyl-; 1,4-Dimethyl-2(1H)-quinolinone; 1,4-dimethyl-1,2-dihydroquinolin-2-one; UNII-6WT6AG3ZQJ; 6WT6AG3ZQJ; 1,4-dimethyl-2-quinolone; 1,4-dimethylquinolin-2-one; ST019653; Q-101237; 2(1H)-quinolinone,1,4-dimethyl-; NSC108420; NSC 108420; 1,4-DIMETHYL-2(1H)-QUINOLONE; casimiroin analogue, 1d; 1,4-dimethylcarbostyril; 4-methyl-n-methylquinolone; AC1Q6I1L; AC1L3Y4F; KSC497K0B; MLS000764269; CHEMBL60376; SCHEMBL436564; ZINC32147; CTK3J7500; BDBM29215
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| Activity |
IC50 ~ 115600 nM
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[6] | |||
| Compound Name |
3,5-Bis(4-methoxyphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939522; 3,5-Di(4-methoxyphenyl)-1,2,4-thiadiazole; SCHEMBL1180509; BDBM50361948; Bis(4-methoxyphenyl)-1,2,4-thiadiazole; 3,5-Bis(4-methoxyphenyl)-1,2,4-thiadiazole #
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-[5-(3-Cyanophenyl)-1,2,4-thiadiazol-3-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939549; BDBM50361975
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis[2-(trifluoromethyl)phenyl]-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939535; BDBM50361961
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(5S,10S,13S)-10,13-Dimethyl-17-pyridin-3-yl-1,2,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-cyclopenta[a]phenanthren-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL84230; BDBM50031676
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| Activity |
IC50 ~ 50000 nM
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[7] | |||
| Compound Name |
3,5-Bis(3-chloro-2-methylphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939538; BDBM50361964
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(2-fluorophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939530; BDBM50361956
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
Bis(4-fluorophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939520; BDBM50361946; 3,5-bis(4-fluorophenyl)-1,2,4-thiadiazole
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(4-nitrophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939547; CTK2I3147; DTXSID80464202; BDBM50361973; 1,2,4-Thiadiazole, 3,5-bis(4-nitrophenyl)-
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(2-bromo-4-methylphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939545; BDBM50361971
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
2-(3-Methoxyphenyl)-4-phenyl-1,3-thiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2208131; BDBM50402770
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
3,5-Bis(2-naphthyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939540; BDBM50361966
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(4-methylphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939539; CTK0A7277; DTXSID60408528; BDBM50361965; Bis(4-methylphenyl)-1,2,4-thiadiazole; 1,2,4-Thiadiazole, 3,5-bis(4-methylphenyl)-
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(4-chloro-2-methylphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939533; BDBM50361959
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
7-Methoxy-3-phenyl-2-(1H-1,2,4-triazol-3-ylsulfanyl)-4H-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL190208; BDBM9898; 2-thioazole isoflavone analog 3d; 7-Methoxy-3-phenyl-2-(1H-1,2,4-triazolyl-3-thio)-4H-1-benzopyran-4-one
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| Activity |
IC50 ~ 50000 nM
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[9] | |||
| Compound Name |
(Z)-Resveratrol
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Investigative | Compound Info | ||
| Synonyms |
cis-resveratrol; Cis resveratrol; UNII-AUA0K06FSB; cis-3,4',5-trihydroxystilbene; 5-[(Z)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; AUA0K06FSB; 5-[(Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; CHEMBL87333; (Z)-3,5,4'-trihydroxystilbene; 5-[(1Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; Resveratrol, (Z)-; 1,3-Benzenediol, 5-((1Z)-2-(4-hydroxyphenyl)ethenyl)-; Resveratrol (Z)-form [MI]; Z-Resveratrol; Resveratrol, Z-; NCGC00015894-02; Tocris-1418; Lopac-R-5010; cis-3,4,5-Trihydroxystilbene; SCHEMBL1931746; cis-3,5,4'-trihydroxystilbene; DTXSID7032002; LUKBXSAWLPMMSZ-UPHRSURJSA-; (Z)-3,4',5-trihydroxystilbene; TNP00294; 1684AH; BDBM50131698; ZINC12353732; AKOS025395422; NCGC00015894-01; NCGC00017352-01; NCGC00017352-02; NCGC00017352-03; NCGC00017352-04; NCGC00024003-02; AC-24235; 434C671; cis-5-[2-(4-Hydroxyphenyl)ethenyl]benzene-1,3-diol; Q27116664; 05F9DB2A-D7E6-4063-8E5B-F7842CF74A5E
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(3-fluorophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939529; BDBM50361955
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
4,4'-(1,2,4-Thiadiazole-3,5-diyl)bisphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939551; SCHEMBL1180545; BDBM50361977; 4,4'-(1,2,4-Thiadiazole-3,5-diyl)diphenol; 4-[5-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2,4-thiadiazolidin-3-ylidene]cyclohexa-2,5-dien-1-one
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
Bis(4-tert-butylphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939526; BDBM50361952; 3,5-bis(4-t-butylphenyl)-1,2,4-thiadiazole
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
1,2,4-Thiadiazole, 3,5-bis(4-chlorophenyl)-
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Investigative | Compound Info | ||
| Synonyms |
3,5-Bis(4-chlorophenyl)-1,2,4-thiadiazole; CHEMBL1939519; BRN 0617952; CTK1D6273; DTXSID90194083; BDBM50361945; Bis(4-chlorophenyl)-1,2,4-thiadiazole
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(3,4-dichlorophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939537; BDBM50361963
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(2-bromophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939523; BDBM50361949
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3,5-Bis(2-chlorophenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
1,3,4-Thiadiazole, 3,5-bis(2-chlorophenyl)-; CHEMBL1939524; BRN 0618654; 3,5-Bis(2-chlorophenyl)-1,3,4-thiadiazole; 1,2,4-Thiadiazole, 3,5-bis(2-chlorophenyl)-; DTXSID20220804; BDBM50361950
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis[4-(trifluoromethyl)phenyl]-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939525; BDBM50361951
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
7-Methoxy-2-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-3-phenyl-4H-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
BDBM9897; CHEMBL190848; 2-thioazole isoflavone analog 3c; 7-Methoxy-2-(1-methyl-1H-imidazolyl-2-thio)-3-phenyl-4H-1-benzopyran-4-one
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
Bis(3-methylphenyl)-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939534; BDBM50361960
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Diphenyl-1,2,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
1,2,4-Thiadiazole, 3,5-diphenyl-; CHEMBL264401; BRN 0172290; AI3-62437; diphenyl-1,2,4-thiadiazole; 4-27-00-07211 (Beilstein Handbook Reference); SCHEMBL2212694; DTXSID30194082; Cl-5998; ZINC6116812; 3,5-diphenyl-[1,2,4]thiadiazole; BDBM50361942
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3,5-Bis(4-butylphenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939541; BDBM50361967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(2,4-dichlorophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939546; BDBM50361972
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2,4-Bis(3-Methoxyphenyl)Thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2208141; SCHEMBL1180783; BDBM50402768; AKOS000990916; 2,4-bis(3-methoxyphenyl)-1,3-thiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3,5-Bis(2-iodophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939544; BDBM50361970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(20S)-21-Aziridinylpregn-5-en-3beta-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2111947; BDBM50409041
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
3,5-Bis(3-bromophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939531; BDBM50361957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(3-Methoxyphenyl)-2-phenyl-1,3-thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2208140; BDBM50402769; AKOS000989971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3,5-Bis(3-iodophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939528; BDBM50361954
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(3-methoxyphenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939550; BDBM50361976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(5-chloro-2-methylphenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939542; BDBM50361968
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4,4'-(1,2,4-Thiadiazole-3,5-diyl)bisbenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939548; BDBM50361974
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(4-bromo-2-methylphenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939543; BDBM50361969
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(2,5-dichlorophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939536; BDBM50361962
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(1H-Imidazol-2-ylsulfanyl)-7-methoxy-3-phenyl-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191488; BDBM9896; 2-thioazole isoflavone analog 3b; 2-(1H-Imidazolyl-2-thio)-7-methoxy-3-phenyl-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Bis(4-bromophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939521; BDBM50361947
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(4-iodophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939527; BDBM50361953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,5-Bis(2,3-dichlorophenyl)-1,2,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939532; BDBM50361958
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-1H-pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL353068; BDBM50049762
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[13] | |||
| Compound Name |
2-Pyridin-3-ylpropan-2-yl Adamantane-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431843; SCHEMBL8067896; BDBM50052666; Adamantane-1-carboxylic acid 1-methyl-1-(3-pyridyl)ethyl ester; Adamantane-1-carboxylic acid 1-methyl-1-pyridin-3-yl-ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[14] | |||
| Compound Name |
1-[(2,4-Dichloro-phenyl)-(2,3-dihydro-benzofuran-2-yl)-methyl]-1H-tetrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65549; BDBM50079819
Click to Show/Hide
|
||||
| Activity |
IC50 = 52020 nM
|
[15] | |||
| Compound Name |
Eicosapentaenoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Timnodonic acid; Icosapent; Icosapentaenoic acid; cis-5,8,11,14,17-Eicosapentaenoic acid; 5,8,11,14,17-EICOSAPENTAENOIC ACID; Icosapento; Icosapentum; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid; (all-Z)-5,8,11,14,17-Eicosapentaenoic acid; UNII-AAN7QOV9EA; Icosapent [INN]; (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid; 5,8,11,14,17-Icosapentaenoic acid; CCRIS 3279; AAN7QOV9EA; (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid; CHEMBL460026; (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate; all-cis-icosa-5,8,11,14,17-pentaenoic acid; Icosapent (INN); cis-Delta(5,8,11,14,17)-eicosapentaenoic acid; 5,8,11,14,17-Eicosapentaenoic acid, (all-Z)-; Icosapentaenoate; (all-Z)-delta5,8,11,14,17-Eicosapentaenoic acid; C20:5n-3,6,9,12,15; MFCD00065716; eicosapentaenoate; cis-5,8,11,14,17-EPA; NCGC00161344-03; EICOSAPENTAENOIC ACID (20:5 n-3); all-cis-5,8,11,14,17-icosapentaenoic acid; all-cis-5,8,11,14,17-eicosapentaenoic acid; Miraxion; Eicosapentanoic acid; Eye Q; Eye-Q; EPA [drug]; Icosapentum [INN-Latin]; C20:5 omega-3; Icosapento [INN-Spanish]; (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate; Timnodonate; FA 20:5; all-cis-icosapentaenoate; all-cis-icosapentaenoic acid; DSSTox_CID_21023; DSSTox_RID_79612; DSSTox_GSID_41023; SCHEMBL20469; BSPBio_001328; EPA 45G; BML3-B01; GTPL3362; DTXSID9041023; HMS1361C10; HMS1791C10; HMS1989C10; HMS3402C10; HMS3649D19; HY-B0660; ZINC4474603; 5,8,11,14,17-Icosapentaenoate; Tox21_111991; 1755AH; 5,8,11,14,17-Eicosapentaenoate; BDBM50242349; LMFA01030759; s6476; AKOS027470327; CCG-207957; CCG-208136; DB00159; cis-5,8,11,14,17-eicosapentaenoate; IDI1_033798; NCGC00161344-01; NCGC00161344-02; NCGC00161344-04; NCGC00161344-07; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoate; AC-31072; AS-53730; E0441; 5,8,11,14,17-Eicosapentaenoic acid (6CI); all cis-5,8,11,14,17-Eicosapentaenoic Acid; all cis-5,8,11,14,17-Icosapentaenoic Acid; C06428; D08061; (all-cis)-5,8,11,14,17-Eicosapentaenoic acid; L001256; Q409990; SR-01000946647; J-001125; SR-01000946647-1; z,z,z,z,z-eicosa-5,8,11,14,17-pentaenoic acid; (Z,Z,Z,Z,Z)-5,8,11,14,17-eicosapentaenoic acid; BRD-K47192521-001-02-1; cis-5,8,11,14,17-Eicosapentaenoic acid, >=99%; 7F8BF016-B146-4F72-A52E-B9298BA3A9AB; C20H30O2 (cis-5,8,11,14,17-eicosapentaenoic acid); Eicosapentaenoic acid, 5,8,11,14,17-(Z,Z,Z,Z,Z)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 53200 nM
|
[16] | |||
| Compound Name |
3-Hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-[4-methoxy-3-(3-methylbut-2-enyl)phenyl]propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229094; SCHEMBL3305900; SCHEMBL13394355; BDBM50213248
Click to Show/Hide
|
||||
| Activity |
IC50 = 54670 nM
|
[17] | |||
| Compound Name |
(R)-16-Bromo-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71363; BDBM50039149
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[18] | |||
| Compound Name |
2-Ethyl-2-pyridin-4-yl-butyric acid (S)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132380; BDBM50029236
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[19] | |||
| Compound Name |
10-Hydroxymethyl-13-methyl-1,3,4,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-7,17-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302741; BDBM50039145
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[18] | |||
| Compound Name |
Methyl (3S)-2-[(4-hydroxyphenyl)methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915401; BDBM50357546
Click to Show/Hide
|
||||
| Activity |
IC50 = 57400 nM
|
[20] | |||
| Compound Name |
Methyl (3S)-2-(cyclopropylmethyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915161; BDBM50357543
Click to Show/Hide
|
||||
| Activity |
IC50 = 58600 nM
|
[20] | |||
| Compound Name |
10-Hydroxymethyl-13-methyl-1,8,9,10,11,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-7,17-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302530; BDBM50039143
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[18] | |||
| Compound Name |
13-Methyl-7,17-dioxo-1,2,3,4,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71169; BDBM50039156
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[18] | |||
| Compound Name |
6-Tert-butyl-3-phenyl-2,3-dihydrochromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011190; BDBM50380178
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[21] | |||
| Compound Name |
10-(1-Hydroxy-prop-2-ynyl)-13-methyl-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL82981; ACMC-20mvo4; Estr-4-en-17-one,10-(1-hydroxy-2-propynyl)-, [10(S)]- (9CI); BDBM50009433
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[22] | |||
| Compound Name |
10-Hydroxymethyl-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308829; BDBM50039141
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[18] | |||
| Compound Name |
Abyssinone II
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389924; 7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chroman-4-one; 7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-2,3-dihydrochromen-4-one; 7-hydroxy-2-(4-hydroxy-3-(3-methylbut-2-enyl)phenyl)chroman-4-one; SCHEMBL3301551; SCHEMBL13394426; CTK5J8822; DTXSID70904182; BDBM50213251; LMPK12140037; MCULE-4551144105; (rac)-7-hydroxy-2-(4-hydroxy-3-(3-methylbut-2-enyl)phenyl)chroman-4-one; 7-Hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)chroman-4-one; 7-Hydroxy-2-[4''-hydroxy-3''-(3-methylbut-2-enyl)phenyl]chroman-4-one; 7-HYDROXY-2-[4-HYDROXY-3-(3-METHYL-BUT-2-ENYL)-PHENYL]-CHROMAN-4-ONE
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[23] | |||
| Compound Name |
2,6-Piperidinedione, 3-ethyl-3-(4-pyridinyl)-, (R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(R)-Rogletimide; UNII-MN5U7K1K5P; MN5U7K1K5P; CHEMBL330452; (R)-3-ethyl-3-(pyridin-4-yl)piperidine-2,6-dione; Rogletimide, (R)-; (+)-(R)-Rogletimide; 3-Ethyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione; SCHEMBL9372682; CTK0C3376; BDBM50003130; ZINC13232857; (3R)-3-ethyl-3-pyridin-4-ylpiperidine-2,6-dione; Q27284120; 2,6-Piperidinedione, 3-ethyl-3-(4-pyridinyl)-, (3R)-; UNII-14P4QR28QF component QXKJWHWUDVQATH-GFCCVEGCSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[24] | |||
| Compound Name |
Methyl (3S)-2-(4-methylphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915156; BDBM50357541
Click to Show/Hide
|
||||
| Activity |
IC50 = 63200 nM
|
[20] | |||
| Compound Name |
Methyl (3S)-2-(2-methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915152; BDBM50357540
Click to Show/Hide
|
||||
| Activity |
IC50 = 64500 nM
|
[20] | |||
| Compound Name |
19-Ethynyl-19-acetoxyandrost-4-ene-3,6,17-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
19-Ethynyl-19-acetoxy-AT; CHEMBL3754543; Estr-4-ene-3,6,17-trione, 10-(1-(acetyloxy)-2-propynyl)-, (10(S))-
Click to Show/Hide
|
||||
| Activity |
Ki = 67000 nM
|
[25] | |||
| Compound Name |
8-Fluoro-3-(pyridin-3-yl)chroman-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3105527; 8-Fluoro-3-pyridin-3-yl-chroman-4-one; BDBM50445502
Click to Show/Hide
|
||||
| Activity |
IC50 = 67100 nM
|
[26] | |||
| Compound Name |
Methyl (3R)-2-methylsulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915159; BDBM50357542
Click to Show/Hide
|
||||
| Activity |
IC50 = 68100 nM
|
[20] | |||
| Compound Name |
(3S)-2-(2-Methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915176; BDBM50357545
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[20] | |||
| Compound Name |
[(1R)-1-[(8R,9S,10R,13S,14S)-13-Methyl-3,6,17-trioxo-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-10-yl]prop-2-ynyl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754046
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[25] | |||
| Compound Name |
4-[(4-Cyanophenyl)-(triazol-2-yl)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1825022; BDBM50351861
Click to Show/Hide
|
||||
| Activity |
IC50 = 79980 nM
|
[27] | |||
| Compound Name |
2-Methyl-2-pyridin-3-yl-propionic acid (3R,6R)-3,6,8,8-tetramethyl-octahydro-3a,7-methano-azulen-6-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444068; BDBM50029231
Click to Show/Hide
|
||||
| Activity |
IC50 = 80500 nM
|
[19] | |||
| Compound Name |
1-(2,4-Dihydroxyphenyl)-3-[4-methoxy-3-(3-methylbut-2-enyl)-phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389925; SCHEMBL3307506; BDBM50213240; 1-(2,4-Dihydroxyphenyl)-3-[4-methoxy-3-(3-methylbut-2-enyl)phenyl]-prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 82940 nM
|
[17] | |||
| Compound Name |
(4-Pyridylmethylene)tetrahydronaphthalene 18a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8628; CHEMBL193858; 4-{[(1E)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-ylidene]methyl}pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 89949.76 nM
|
[28] | |||
| Compound Name |
(3R)-3alpha-Ethyl-5beta-methyl-3-(4-pyridinyl)piperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124118; 3-Ethyl-5-methyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione; BDBM50003136
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[24] | |||
| Compound Name |
4a,7-Dimethyl-7-propionyl-4b,5,6,7,8,8a,9,10-octahydro-4aH-phenanthren-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158325; BDBM50020642
Click to Show/Hide
|
||||
| Activity |
Ki = 97000 nM
|
[29] | |||
| Compound Name |
2'-Methoxyisoflavanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011181; BDBM50380170
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[21] | |||
| Compound Name |
1,4-Dimethylquinoline-2,5,8(1H)-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinone, 12; CHEMBL450666; BDBM29230; 1,4-dimethylquinoline-2,5,8-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 98400 nM
|
[6] | |||
| Compound Name |
3-(3-Methoxyphenyl)-2,3-dihydrochromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011182; SCHEMBL13267887; BDBM50380171
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[21] | |||
| Compound Name |
7-Methoxy-3-phenyl-2-(pyridin-2-ylmethylsulfanyl)chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362906; Isoflavone 3g; BDBM9451; SCHEMBL3815332; 7-methoxy-3-phenyl-2-[(2-pyridylmethyl)thio]-4h-1-benzopyran-4-one; 7-methoxy-3-phenyl-2-[(pyridin-2-ylmethyl)sulfanyl]-4H-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Acetic acid 10-hydroxymethyl-13-methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL81255; BDBM50009438
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[22] | |||
| Compound Name |
7-(Benzyloxy)-2-(benzylsulfanyl)-3-(4-methoxyphenyl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isoflavone 3b; BDBM9446; CHEMBL361872; SCHEMBL3816936; 2-benzylsulfanyl-3-(4-methoxyphenyl)-7-phenylmethoxychromen-4-one; 3-(4-methoxyphenyl)-7-(phenylmethoxy)-2-[(phenylmethyl)thio]-4h-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
2H-1-Benzopyran-2-one, 4-[2-(1H-imidazol-1-yl)ethoxy]-7-methoxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Coumarin deriv. 23; BDBM9474; CHEMBL375497; CTK3D6005; DTXSID90459927; 4-[2-(1H-Imidazol-1-yl)ethoxy]-7-methoxy-2H-chromen-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[31] | |||
| Compound Name |
CID 71621803
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077246; SCHEMBL15018509; BDBM50268690
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-(Allylthio)-3-phenyl-7-methoxy-4H-1-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isoflavone 3c; BDBM9447; CHEMBL264724; 7-methoxy-3-phenyl-2-(prop-2-en-1-ylsulfanyl)-4H-chromen-4-one; 7-Methoxy-3-phenyl-2-[(propen-3-yl)thio]-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
3-(4-Methoxyphenyl)-7-(phenylmethoxy)-2-[(propen-3-yl)thio]-4H-1-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isoflavone 3a; BDBM9445; CHEMBL185966; 7-(benzyloxy)-3-(4-methoxyphenyl)-2-(prop-2-en-1-ylsulfanyl)-4H-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Imidazolin-2-one, 11a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229861; SCHEMBL2965294; BDBM18177
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
2-(Benzylsulfanyl)-7-methoxy-3-phenyl-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isoflavone 3d; BDBM9448; CHEMBL189170; SCHEMBL3810768; 2-benzylsulfanyl-7-methoxy-3-phenylchromen-4-one; 2-(Benzylthio)-3-phenyl-7-methoxy-4H-1-benzopyran-4-one; 7-methoxy-3-phenyl-2-[(phenylmethyl)thio]-4h-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
3,4-Dihydro-2-[(E)-(pyridazin-4-yl)methylene]naphthalen-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424556; BDBM50049769; ZINC13746649; 2-[1-Pyridazin-4-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 103000 nM
|
[13] | |||
| Compound Name |
1,2,4b-Trimethyl-7-oxo-1,2,3,4,4a,4b,7,9,10,10a-decahydro-phenanthrene-2-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423772; BDBM50020644
Click to Show/Hide
|
||||
| Activity |
Ki = 103000 nM
|
[29] | |||
| Compound Name |
8-Methoxy-4-methylquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Methoxy-4-methyl-1H-quinolin-2-one; 2-Hydroxy-4-methyl-8-methoxyquinoline; 8-Methoxy-4-methylquinolin-2-ol; BAS 00898394; casimiroin analogue, 1e; SpecPlus_000427; Enamine_005066; 2(1H)-Quinolinone, 8-methoxy-4-methyl-; Spectrum5_000925; Oprea1_088427; Oprea1_150018; DivK1c_006523; CHEMBL453417; SCHEMBL5433980; BDBM29216; CTK4G4649; CTK8D9638; KBio1_001467; DTXSID40354791; HMS1408G06; 2-HYDROXY-8-METHOXYLEPIDINE; ALBB-031722; MFCD02269198; STK856540; ZINC16284037; 8-methoxy-4-methylhydroquinolin-2-one; AKOS001072892; AKOS004119147; MCULE-9748555043; IDI1_007653; 4-Methyl-8-methoxyquinoline-2(1H)-one; 2(1H)-Quinolinone,8-methoxy-4-methyl-; ST50209072; Q27457145
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 105800 nM
|
[6] | |||
| Compound Name |
Quinoline, 5,6,7,8-tetrahydro-8-(1H-imidazol-1-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
tetrahydroquinoline 41; CHEMBL301608; BDBM10039; 8-(Imidazol-1-yl)-5,6,7,8-tetrahydroquinoline; 5,6,7,8-Tetrahydro-8-(1H-imidazole-1-yl)quinoline; 8-(1H-imidazol-1-yl)-5,6,7,8-tetrahydroquinoline
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[34] | |||
| Compound Name |
(1R,2S,5S,6S,9S,10R,16S)-1,5-Dimethyl-14-oxa-13-azapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-12,15(19)-diene-6,16-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3751861
Click to Show/Hide
|
||||
| Activity |
IC50 = 120500 nM
|
[25] | |||
| Compound Name |
4-Methylquinolin-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Hydroxy-4-methylquinoline; 4-methylquinolin-2(1H)-one; 4-Methyl-2-quinolinol; 2-Hydroxylepidine; 4-Methyl-2-quinolone; 4-Methylcarbostyril; 4-Methyl-2-hydroxyquinoline; 2(1H)-Lepidinone; 4-Methyl-1H-quinolin-2-one; 2-Lepidinol; 2(1H)-Quinolinone, 4-methyl-; 4-Methyl-2(1H)-quinolinone; 4-Methylquinolin-2-one; Carbostyril, 4-methyl-; NSC 2057; 4-methyl-quinolin-2-ol; AI3-00843; NSC2057; EINECS 210-139-0; Lepidine, 2-hydroxy; PubChem5862; 4-Methylquinol-2-one; ACMC-1ATIM; casimiroin analogue, 1c; 2-Quinolinol, 4-methyl-; Cc1cc([O])nc2ccccc12; 4-methylhydroquinolin-2-one; Oprea1_272485; Oprea1_547052; Oprea1_780405; cid_69088; MLS000096591; SCHEMBL377555; ARONIS003785; CHEMBL424414; BDBM29214; CTK3E9909; DTXSID20976132; HMS1722B17; HMS2320G05; ALBB-026701; BCP33184; KS-00001VO4; NSC-2057; ZINC8586366; 2-Hydroxy-4-methylquinoline, 97%; ANW-33569; BBL010584; MFCD00006745; SBB003978; STK038061; STL304705; 1,2-Dihydro-4-methyl-2-oxoquinoline; AKOS000120372; AKOS001041007; 3N-601S; DS-1525; MCULE-8758121655; QC-1595; SDCCGMLS-0027272.P002; Carbostyril, 4-methyl- (VAN) (8CI); NCGC00036814-02; NCGC00036814-03; NCGC00036814-04; NCGC00036814-05; NCGC00036814-06; NCGC00036814-07; AK-38350; BR-38350; SC-46615; SMR000062448; AB0026993; DB-053698; CS-0097736; FT-0612620; ST45023855; W8764; Y5486; S-4157; A832875; 4-Methylquinolin-2-ol;4-Methylquinolin-2(1H)-one; J-515819; Q27121422; F0109-0047; F0183-0103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125700 nM
|
[6] | |||
| Compound Name |
9-Hydroxy-7,8-dimethyl-7-[2-(5-oxo-2H-furan-3-yl)ethyl]-5,6,6a,8,9,10-hexahydro-1H-benzo[d][2]benzofuran-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC383467; NSC-383467; CHEMBL582837; BDBM50298488; 9-hydroxy-7,5 di- hydrofuran-3-yl)ethyl)-6,6a,7,8,9,10-hexahydro 1H-naphtho[1-c]furan-3(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[35] | |||
| Compound Name |
2,4b-Dimethyl-7-oxo-1,2,3,4,4a,4b,7,9,10,10a-decahydro-phenanthrene-2-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346929; BDBM50020643
Click to Show/Hide
|
||||
| Activity |
Ki = 130000 nM
|
[29] | |||
| Compound Name |
2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL29138; SCHEMBL19585699; BDBM50025063; 3-(4-aminophenyl)-3-methylpiperidine-2,6-dione; 3-(4-Amino-phenyl)-3-methyl-piperidine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 135000 nM
|
[36] | |||
| Compound Name |
17-Hydroxy-10-hydroxymethyl-13-methyl-1,2,3,4,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421491; BDBM50039142
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[18] | |||
| Compound Name |
4beta-Methoxy-19-hydroxyandrosta-5-ene-17-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630275; BDBM50332825; ZINC13470374
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[37] | |||
| Compound Name |
4'-Hydroxyisoflavanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011192; SCHEMBL4806201; 3-(4-Hydroxyphenyl)chroman-4-one; BDBM50380180; 3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[21] | |||
| Compound Name |
2-Hydroxyisoflavanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011191; 2-hydroxy-3-phenylchroman-4-one; SCHEMBL501137; CTK1F5479; DTXSID30532465; BDBM50380161; 2-hydroxy-3-phenyl-2,3-dihydrochromen-4-one; 2-Hydroxy-3-phenyl-2,3-dihydro-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-2-hydroxy-3-phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[21] | |||
| Compound Name |
4-Methyl-2-oxo-2H-chromene-5,7-diyl-dibutyrate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC688803; CHEMBL583310; NSC-688803; CTK8C8990; ZINC1651366; BDBM50298489; NCI60_032001; 4-methyl-2-oxo-2h-chromene-5,7-diyl dibutanoate; 4-methyl-2-oxo-2H-chromene-5,7-diyl dibutyrate; (5-butanoyloxy-4-methyl-2-oxo-chromen-7-yl) butanoate; 5-(Butyryloxy)-4-methyl-2-oxo-2H-chromen-7-yl butyrate
Click to Show/Hide
|
||||
| Activity |
IC50 = 176000 nM
|
[35] | |||
| Compound Name |
2-(4-Phenoxyphenyl)-2,3-dihydrobenzo[f]chromen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3105524; BDBM50445504
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[26] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 56 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LICOAGROCHALCONE A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
licoagrochalcone A; 3-Prenyl-4,2',4'-trihydroxychalcone; CHEMBL229885; 2',4,4'-trihydroxy-3-prenylchalcone; 202815-28-9; SCHEMBL632907; LMPK12120068; BDBM50212400; ACM202815289; (E)-2',4,4'-Trihydroxy-3-prenylchalcone; 1-(2,4-Dihydroxyphenyl)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 308300 nM
|
[17] | |||
| Compound Name |
4-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-Pyridylmethylene)indane 10a; CHEMBL366773; BDBM8620; AC1O7063; 4-[(E)-(5-bromo-2,3-dihydroinden-1-ylidene)methyl]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 3396252.73 nM
|
[28] | |||
| Compound Name |
3',4'-Dihydroxyisoflavanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011193; SCHEMBL13840362; 3-(3,4-Dihydroxyphenyl)chroman-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 >= 200000 nM
|
[21] | |||
| Compound Name |
(3R)-3alpha-Ethyl-5,5-dimethyl-3-(4-pyridinyl)piperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269761; BDBM50003132; 3-Ethyl-5,5-dimethyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
3-Phenyl-7-phenylmethoxy-2-(pyridin-4-ylmethylsulfanyl)chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188664; Isoflavone 3j; BDBM9454; SCHEMBL15061273; 7-(benzyloxy)-3-phenyl-2-[(pyridin-4-ylmethyl)sulfanyl]-4H-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 210000 nM
|
[38] | |||
| Compound Name |
1-[2-Hydroxy-4-(methoxymethoxy)phenyl]-3-[3-(3-methyl-2-butenyl)-4-(methoxymethoxy)phenyl]-2-propene-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229944; SCHEMBL3299183; BDBM50213244
Click to Show/Hide
|
||||
| Activity |
IC50 > 242400 nM
|
[17] | |||
| Compound Name |
2,6-Piperidinedione, 3-methyl-3-(4-pyridinyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL38510; 3-methyl-3-(pyridin-4-yl)piperidine-2,6-dione; DTXSID20874184; BDBM50024551; AKOS033920277; 3-Methyl-3-(4-pyridyl)piperidine-2,6-dione; Z2467129361
Click to Show/Hide
|
||||
| Activity |
IC50 = 245000 nM
|
[39] | |||
| Compound Name |
3-Methyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89046; BDBM50015984; ZINC26636994
Click to Show/Hide
|
||||
| Activity |
IC50 = 245000 nM
|
[40] | |||
| Compound Name |
2-(Hydroxy-pyrazin-2-yl-methyl)-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169449; BDBM50049761; 3,4-Dihydro-2-[hydroxy(pyrazin-2-yl)methyl]naphthalen-1(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
3,4-Dihydro-2-[(E)-(3-thienyl)methylene]naphthalen-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL166974; ZINC5128638; BDBM50049767; AKOS000991522; NCGC00320515-01; AB01114148-03; 2-[1-Thiophen-3-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
2-(Hydroxy-pyridazin-4-yl-methyl)-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168762; BDBM50049781; 3,4-Dihydro-2-[hydroxy(pyridazin-4-yl)methyl]naphthalen-1(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
1-Phenyl-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168700; BDBM50049766
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
2-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL166789; BDBM50049771
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
3,4-Dihydro-2-[(E)-(pyridazin-3-yl)methylene]naphthalen-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL166709; BDBM50049764; ZINC13746672; 2-[1-Pyridazin-3-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
2-(2-Pyridylmethylene)-3,4-dihydro-1(2H)-naphthalenone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424203; MLS003115410; NSC 270711; BRN 1461621; NSC270711; Bio7D8; 1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-2-(2-PYRIDYLMETHYLENE)-; 5-21-09-00177 (Beilstein Handbook Reference); cid_26160; HMS562P07; ZINC4695498; BDBM50049770; NSC-270711; 2-(2-Pyridinylmethylene)tetralin-1-one; 3,4-Dihydro-2-[(E)-(2-pyridinyl)methylene]naphthalen-1(2H)-one; 2-[1-Pyridin-2-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
3-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-thiophene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433728; BDBM50049772
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
3,4-Dihydro-2-[(E)-(2-aminothiazol-5-yl)methylene]naphthalen-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355681; BDBM50049782; 2-[1-(2-Amino-thiazol-5-yl)-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
2-(Hydroxy-pyridazin-3-yl-methyl)-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169664; BDBM50049780; 3,4-Dihydro-2-[hydroxy(pyridazin-3-yl)methyl]naphthalen-1(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
2-Benzylidene-1-tetralone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2E)-2-(phenylmethylidene)-1,2,3,4-tetrahydronaphthalen-1-one; CHEMBL28689; (2E)-2-benzylidene-3,4-dihydronaphthalen-1-one; (2E)-2-benzylidene-3,4-dihydronaphthalen-1(2H)-one; 1(2H)-Naphthalenone, 3,4-dihydro-2-(phenylmethylene)-; (2E)-2-benzylidenetetralin-1-one; MFCD00019675; NSC665347; (E)-3,4-Dihydro-2-(phenylmethylene)-1(2H)-naphthalenone; 2-benzylidene-3,4-dihydronaphthalen-1(2H)-one; 1(2H)-Naphthalenone, 3,4-dihydro-2-(phenylmethylene)-, (E)-; 2-Benzylidenetetralin-1-one; 1(2H)-Naphthalenone, 2-benzylidene-3,4-dihydro-; SCHEMBL820654; (e)-2-benzylidene-1-tetralone; 2--Phenylmethylene-1-tetralone; (E)-2-Benzylidenetetralin-1-one; HMS1452P11; ZINC1036032; BBL009175; BDBM50049779; STK246954; AKOS000478650; NSC-665347; IDI1_019024; NCGC00327129-01; ST50410407; 2,4-DIMETHYL-6-METHOXYPHENYLBORONICACID; 2-(phenylmethylene)-3,4-dihydronaphthalen-1-one; 2-benzylidene-3,4-dihydro-2h-naphthalen-1-one; AB01321615-02; (2E)-2-Benzylidene-3,4-dihydro-1(2H)-naphthalenone #; 2-[1-Phenyl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one
Click to Show/Hide
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||||
| Activity |
IC50 > 250000 nM
|
[13] | |||
| Compound Name |
1-[2-Hydroxy-4-(methoxymethoxy)phenyl]-3-[4-methoxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229893; SCHEMBL3305503; BDBM50213237
Click to Show/Hide
|
||||
| Activity |
IC50 > 261500 nM
|
[17] | |||
| Compound Name |
1-(2-Hydroxy-4-methoxyphenyl)-3-[4-(methoxymethoxy)-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390731; SCHEMBL3305922; BDBM50213250
Click to Show/Hide
|
||||
| Activity |
IC50 > 261500 nM
|
[17] | |||
| Compound Name |
1-(2-Hydroxy-4-methoxyphenyl)-3-[4-(3-methylbut-2-enyloxy)phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390364; SCHEMBL3301455; BDBM50213249
Click to Show/Hide
|
||||
| Activity |
IC50 > 271400 nM
|
[17] | |||
| Compound Name |
1-(2-Hydroxy-4-methoxyphenyl)-3-[4-methoxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229633; SCHEMBL3304113; BDBM50213233
Click to Show/Hide
|
||||
| Activity |
IC50 > 283750 nM
|
[17] | |||
| Compound Name |
3-[4-Hydroxy-3-(3-methylbut-2-enyl)phenyl]-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229841; SCHEMBL3307174; BDBM50213246
Click to Show/Hide
|
||||
| Activity |
IC50 > 295500 nM
|
[17] | |||
| Compound Name |
9-Methoxy-6,6aalpha,11,11aalpha-tetrahydro[1]benzopyrano[4,3-b]indole-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134228
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[41] | |||
| Compound Name |
3-(4-Aminophenyl)piperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2,6-Piperidinedione, 3-(4-aminophenyl)-; CHEMBL28880; ACMC-20lvjc; SCHEMBL1553566; CTK3G1865; DTXSID70546041; BDBM50025053; 3-(4-Amino-phenyl)-piperidine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[36] | |||
| Compound Name |
1-(2-Hydroxyphenyl)-3-[4-methoxy-3-(3-methylbut-2-enyl)-phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388375; BDBM50213247
Click to Show/Hide
|
||||
| Activity |
IC50 > 310170 nM
|
[17] | |||
| Compound Name |
1-(2-Hydroxy-4-methoxyphenyl)-3-[3-(3-methylbut-2-enyl)-phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229905; SCHEMBL3305938; BDBM50213242
Click to Show/Hide
|
||||
| Activity |
IC50 > 310200 nM
|
[17] | |||
| Compound Name |
1-(2-Hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2'-Hydroxy-4,4'-dimethoxychalcone; 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one; CHEMBL229907; (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one; Isoliquiritigenin 4,4'-dimethyl ether; NSC78638; MLS000438960; SCHEMBL634186; HMS2206A19; 4,4'-dimethoxy-2'-hydroxychalcone; ZINC4252588; BDBM50213232; CMLD3_000158; LMPK12120100; MFCD00098911; NSC 78638; NSC-78638; 2''-hydroxy-4,4''-dimethoxychalcone; AKOS002385545; NCGC00090537-01; (E)-2'-Hydroxy-4,4'-dimethoxychalcone; SMR000112982; ST059922; 4,4'-Dimethoxy-2'-hydroxychalcone, AldrichCPR; AE-641/01149036; 2-Hydroxy-4-methoxy-alpha-(p-methoxybenzylidene)acetophenone; (2E)-1-(2-Hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one #; (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one; (E)-1-(2-hydroxy-4-methoxy-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 351700 nM
|
[17] | |||
| Compound Name |
(S)-Aminoglutethimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-(-)-Aminoglutethimide; (D)-Aminoglutethimide; (-)-Aminoglutethimide; UNII-5S1T2OED7F; 5S1T2OED7F; CHEMBL1394757; (3S)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione; 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-, (3S)-; 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-, (3R)-; D-Aminoglutethimide; NCGC00016379-01; Aminoglutethimide, (S)-; Lopac-A-9657; (-)-(S)-Aminoglutethimide; SCHEMBL116988; ZINC1530855; (S)-(-)-Aminoglutethimide, 97%; BDBM50406640; NCGC00015110-01; Q27124214; UNII-0O54ZQ14I9 component ROBVIMPUHSLWNV-ZDUSSCGKSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 = 370000 nM
|
[42] | |||
| Compound Name |
1,3-Diethyl-3-pyridin-4-ylpiperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39781; 1,3-Diethyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione; BDBM50024552
Click to Show/Hide
|
||||
| Activity |
IC50 = 385000 nM
|
[39] | |||
| Compound Name |
(3R)-1,3-Diethyl-3-pyridin-4-ylpiperidine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327239; 1,3-Diethyl-4,5-dihydro-3H-[3,4'']bipyridinyl-2,6-dione; BDBM50015978
Click to Show/Hide
|
||||
| Activity |
IC50 = 385000 nM
|
[40] | |||
| Compound Name |
Lafis-10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL270215; BDBM50225900; N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[43] | |||
| Compound Name |
Ursonic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
3-Oxours-12-en-28-oic acid; 3-Oxo-urs-12-en-28-oic acid; CHEMBL487887; (5beta)-3-oxours-12-en-28-oic acid; 3-Ketoursolic acid; 3-Oxo-12-ursen-28-oic acid; 3-Ketone; SCHEMBL454577; HMS3885G12; HY-N1486; BDBM50245647; MFCD09752413; s3902; ZINC13558221; AKOS016009365; CCG-269282; CS-5796; DS-5490; 246O464
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[43] | |||
| Compound Name |
N-{3-[4-(3-Aminopropyl)piperazinyl]propyl}-ursolamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264924; BDBM50225913
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[43] | |||
| Compound Name |
4-Aza-A-homo-3-oxo-ursolic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL454421; BDBM50245704
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[43] | |||
| Compound Name |
2-Cyano-2,3-seco-4-yliden-olean-12-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486853; BDBM50245649
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[43] | |||
| Compound Name |
4'-Hydroxytamoxifen
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(Z)-4'-hydroxytamoxifen; CHEMBL10041; trans-Hydroxytamoxifen; 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol; 4-{(1Z)-1-[{4-[2-(dimethylamino)ethoxy]phenyl}(phenyl)methylene]propyl}phenol; 4Hydroxy Tamoxifen; NCGC00091028-01; GTPL2817; SCHEMBL2165503; DTXSID00873019; ZINC8602413; BDBM50180684; NCGC00091028-02; Q27073761; 4 inverted exclamation mark -Hydroxy Tamoxifen (contains up to 10% E isomer); 4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-1-phenylbut-1-en-2-yl] phenol
Click to Show/Hide
|
||||
| Activity |
IC50 = 530000 nM
|
[44] | |||
| Compound Name |
Afimoxifene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)-phenyl)-2-phenylbut-1-en-1-yl)phenol; (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol; (E/Z)-4-Hydroxytamoxifen; 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol; DSSTox_CID_28161; DSSTox_RID_79302; DSSTox_GSID_37094; MLS003106263; CHEMBL2137046; DTXSID3037094; BCBcMAP01_000199; CTK8E2879; CTK8E7487; HMS3370G08; BCP04749; BCP23058; Tox21_303657; BDBM50276802; s7827; AKOS028114525; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-; CCG-268491; 4-Hydroxytamoxifen (4-HT, Afimoxifene; SMP1_000161; NCGC00249622-01; NCGC00257332-01; SMR001819827; FT-0647372; FT-0670138; FT-0670142; FT-0670146; KS-00001838; Q27163871; (E)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
Click to Show/Hide
|
||||
| Activity |
IC50 = 530000 nM
|
[45] | |||
| Compound Name |
4-[(E)-3,4-Dihydro-2H-naphthalen-1-ylidenemethyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-Pyridylmethylene)tetrahydronaphthalene 4a; BDBM8613; CHEMBL360026; SCHEMBL4231728; SCHEMBL4231733; 4-[(E)-3,4-Dihydronaphthalen-1(2H)-ylidenemethyl]pyridine; 4-[(1E)-1,2,3,4-tetrahydronaphthalen-1-ylidenemethyl]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 650129.69 nM
|
[28] | |||
| Compound Name |
(Isoquinolinemethylene)indane 30a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8639; CHEMBL370530; SCHEMBL8272636; 5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]methyl}isoquinoline
Click to Show/Hide
|
||||
| Activity |
IC50 = 719448.98 nM
|
[28] | |||
| Compound Name |
(1S,5R)-1-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27767; 1-(4-Amino-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione; SCHEMBL10530941; BDBM50011757
Click to Show/Hide
|
||||
| Activity |
IC50 = 777000 nM
|
[46] | |||
| Compound Name |
4-{[(1E)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ylidene]methyl}pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8624; CHEMBL175979; SCHEMBL4219955; SCHEMBL4219959; (4-Pyridylmethylene)tetrahydronaphthalene 14a
Click to Show/Hide
|
||||
| Activity |
IC50 = 799834.26 nM
|
[28] | |||
| Compound Name |
2,4b-Dimethyl-7-oxo-1,2,3,4,4a,4b,7,9,10,10a-decahydro-phenanthrene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158717; BDBM50020638
Click to Show/Hide
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||||
| Activity |
Ki = 893000 nM
|
[29] | |||
| Compound Name |
(3-Pyridylmethylene)tetrahydronaphthalene 17a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8602; CHEMBL366669; 3-{[(1E)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-ylidene]methyl}pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 979489.99 nM
|
[28] | |||
| Compound Name |
4-[(Z)-(6-Methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)methyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-Pyridylmethylene)tetrahydronaphthalene 14b; BDBM8625; CHEMBL193496; SCHEMBL4219957; 4-{[(1Z)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylidene]methyl}pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 1009252.89 nM
|
[28] | |||
| Compound Name |
3-{[(1E)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ylidene]methyl}pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8595; CHEMBL362441; SCHEMBL4226278; SCHEMBL4226289; (3-Pyridylmethylene)tetrahydronaphthalene 13a
Click to Show/Hide
|
||||
| Activity |
IC50 = 1129795.91 nM
|
[28] | |||
| Compound Name |
1,2,4b-Trimethyl-7-oxo-1,2,3,4,4a,4b,7,9,10,10a-decahydro-phenanthrene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160271; BDBM50020646
Click to Show/Hide
|
||||
| Activity |
Ki = 1198000 nM
|
[29] | |||
| Compound Name |
5-{[(1Z)-5-Fluoro-2,3-dihydro-1H-inden-1-ylidene]methyl}isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8640; CHEMBL363849; (isoquinolinemethylene)indane 30b
Click to Show/Hide
|
||||
| Activity |
IC50 = 1940885.88 nM
|
[28] | |||
| Compound Name |
3-[(Z)-3,4-Dihydro-2H-naphthalen-1-ylidenemethyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(3-Pyridylmethylene)tetrahydronaphthalene 3b; BDBM8585; CHEMBL365120; SCHEMBL4236142; 3-[(1Z)-1,2,3,4-tetrahydronaphthalen-1-ylidenemethyl]pyridine; 3-[(Z)-3,4-Dihydronaphthalen-1(2H)-ylidenemethyl]pyridine Hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 3793149.85 nM
|
[28] | |||
| Compound Name |
3-[(Z)-(6-Methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)methyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(3-Pyridylmethylene)tetrahydronaphthalene 13b; BDBM8596; CHEMBL176098; SCHEMBL4226283; 3-{[(1Z)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylidene]methyl}pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 3999447.5 nM
|
[28] | |||
| Compound Name |
3-[(1E)-1,2,3,4-Tetrahydronaphthalen-1-ylidenemethyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM8584; CHEMBL193606; SCHEMBL4236141; SCHEMBL4236146; (3-Pyridylmethylene)tetrahydronaphthalene 3a; 3-[(E)-3,4-Dihydronaphthalen-1(2H)-ylidenemethyl]pyridine Hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 6576578.37 nM
|
[28] | |||
| Compound Name |
7-(Benzyloxy)-2-(1H-imidazol-1-yl)-3-phenyl-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363493; azole isoflavone analog 2c; BDBM9893; 2-(1H-Imidazol-1-yl)-3-phenyl-7-(benzyloxy)-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 5.13E+11 nM
|
[10] | |||
| Compound Name |
2-(1H-Imidazol-1-yl)-7-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189472; azole isoflavone analog 2b; BDBM9892; 2-(1H-Imidazol-1-yl)-7-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.95E+12 nM
|
[10] | |||
| Compound Name |
7-(Benzyloxy)-2-(1H-imidazol-1-yl)-3-(4-methoxyphenyl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189274; azole isoflavone analog 2d; BDBM9894; 2-(1H-Imidazol-1-yl)-3-(4-methoxyphenyl)-7-(benzyloxy)-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 4.68E+12 nM
|
[10] | |||
| Compound Name |
7-Methoxy-3-phenyl-2-(1H-1,2,4-triazol-1-yl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190099; azole isoflavone analog 3a; BDBM9895; 7-Methoxy-3-phenyl-2-(1H-1,2,4-triazol-1-yl)-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.82E+13 nM
|
[10] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. J Med Chem. 2010 Jul 8;53(13):5049-53. | ||||
| REF 2 | Screening of herbal constituents for aromatase inhibitory activity. Bioorg Med Chem. 2008 Sep 15;16(18):8466-70. | ||||
| REF 3 | 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. J Med Chem. 1997 Oct 24;40(22):3494-6. | ||||
| REF 4 | Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. Bioorg Med Chem. 2012 Jan 1;20(1):510-20. | ||||
| REF 5 | Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)). Bioorg Med Chem Lett. 2009 Aug 15;19(16):4698-701. | ||||
| REF 6 | Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. | ||||
| REF 7 | Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. J Med Chem. 1995 Jun 23;38(13):2463-71. | ||||
| REF 8 | Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). Bioorg Med Chem. 2012 Dec 15;20(24):7030-9. | ||||
| REF 9 | Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. | ||||
| REF 10 | Synthesis and characterization of azole isoflavone inhibitors of aromatase. Bioorg Med Chem. 2005 Jun 2;13(12):4063-70. | ||||
| REF 11 | Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives. Bioorg Med Chem. 2018 May 1;26(8):1986-1995. | ||||
| REF 12 | Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). J Med Chem. 2000 Nov 16;43(23):4437-45. | ||||
| REF 13 | Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17. J Med Chem. 1996 Feb 16;39(4):834-41. | ||||
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