Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T21307 | Target Info | |||
| Target Name | MAPK-activated protein kinase 2 (MAPKAPK2) | ||||
| Synonyms |
MK2; MK-2; MAPKactivated protein kinase 2; MAPKAPK-2; MAPKAP-K2; MAPKAP kinase 2; MAP kinaseactivated protein kinase 2; MAP kinase-activated protein kinase 2
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPKAPK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 81 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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|
Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
BMS-695735
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Preclinical | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
A-432411
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Investigative | Compound Info | ||
| Synonyms |
43A; (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE; 2ayp; indolinone analog 13; A-432411; CHEMBL202930; SCHEMBL6674605; BDBM14649; DB07078; 29690-EP2311842A2; 29690-EP2289868A1; 29690-EP2289894A2; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Tpl2 kinase inhibitor
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Investigative | Compound Info | ||
| Synonyms |
Tpl2 Kinase Inhibitor; 871307-18-5; 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile; CHEMBL200381; 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine; K00599a; 4-[(3-chloro-4-fluorophenyl)amino]-6-[(pyridin-3-ylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
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| Activity |
IC50 = 110000 nM
|
[4] | |||
| Compound Name |
1-((3-Amino-6-phenylpyrazin-2-yl)methyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783564; BDBM50345833
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
CID 46179972
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163016; BDBM50378568
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-phenethylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783553; BDBM50345822
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine
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Investigative | Compound Info | ||
| Synonyms |
isoquinoline-pyridine, 1; isoquinoline-pyridine, 3; 5-isoquinolinyl pyridine 2; pyridine-base inhibitor 13a; CHEMBL383264; SCHEMBL6855488; BDBM15067; 13a (S-); 6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinoline
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080994; SCHEMBL2934634; BDBM50311953
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
1-((3-Amino-6-(trifluoromethyl)pyrazin-2-yl)methyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783562; BDBM50345831
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095873; SCHEMBL4482804; BDBM50317750
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
1-((3-Amino-6-chloro-5-ethoxypyrazin-2-yl)methyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783566; BDBM50345835
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
7-Amino-4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL445178; thieno[2,3-c]pyridine, 10b; BDBM28044
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
1-((3-Amino-6-chloro-5-(dimethylamino)pyrazin-2-yl)methyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783565; BDBM50345834
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL438485; SCHEMBL4809259; SCHEMBL4809267; BDBM91830; BDBM50204694; ZINC100469705; ZINC253994709; Q27456666
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080995; SCHEMBL2934911; BDBM50311954
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|
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
2-({2-[(3-Hydroxyphenyl)amino]pyrimidin-4-YL}amino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
DB07268; DB-07268; 2-((2-((3-Hydroxyphenyl)amino)pyrimidin-4-yl)amino)benzamide; 4-(2-carbamoylanilino)-2-(3-hydroxyanilino)pyrimidine; 4-anilinopyrimidine 2b; CHEMBL242237; BDBM15978; BCP16456; EX-A2356; MFCD26960941; s6740; ZINC14960224; AKOS027439962; CS-1562; NCGC00378943-01; NCGC00378943-02; AS-56032; DB 07268; HY-15737; Q27096495; 2-[[2-(3-hydroxyanilino)pyrimidin-4-yl]amino]benzamide; 2-(4-(3-hydroxyphenylamino)pyrimidin-2-ylamino)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
BMS-605541; CHEMBL377734; BMS 605541; SCHEMBL2861987; BDBM50189603; AKOS034831603
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 ~ 50000 nM
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[18] | |||
| Compound Name |
7-(7-(Benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5-(cyclopenta-2,4-dienyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605922; BDBM50305015
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| Activity |
IC50 ~ 50000 nM
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[19] | |||
| Compound Name |
1-((3-Amino-6-chloro-5-(methylthio)pyrazin-2-yl)methyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783567; BDBM50345836
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-{1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene}-2,3-dihydro-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
indolinone analog 28; CHEMBL383316; SCHEMBL6671445; BDBM14664; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-1H-indol-2-one
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-(3-(diethylamino)propyl)thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783555; BDBM50345824
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-cyclopentylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783550; BDBM50345819
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| Activity |
IC50 = 53000 nM
|
[5] | |||
| Compound Name |
7-Hydroxy-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL247343; SCHEMBL6240868; BDBM50215525
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| Activity |
IC50 = 53000 nM
|
[20] | |||
| Compound Name |
8,10-Diamino-3,11-dihydro-2H-[1,4]dioxino[2,3-b]xanthene-9-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706773
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| Activity |
IC50 = 55700 nM
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[21] | |||
| Compound Name |
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4-propyl-1H-imidazol-5-yl)methyl]amino}quinoline-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
Cyanoquinoline, 40; CHEMBL230654; BDBM21929
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| Activity |
IC50 = 62700 nM
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[22] | |||
| Compound Name |
Cot inhibitor-2
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Investigative | Compound Info | ||
| Synonyms |
Wyeth Cot Inhibitor 2; C26H25Cl2FN8; CHEMBL527026; SCHEMBL4962096; BDBM29923; DTXSID50657644; HMS3295K05; 3403AH; MFCD13184702; ZINC42921365; NCGC00273985-02; NCGC00273985-03; NCGC00273985-04; HY-32018; DB-015004; FT-0759876; W-5556; substituted 6-aminoquinoline-3-carbonitrile, 34; 363Q563; BRD-K49468759-001-01-8; Q27163268
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| Activity |
IC50 = 63000 nM
|
[23] | |||
| Compound Name |
3-Ethyl-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL247911; SCHEMBL6237701; BDBM50215528
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| Activity |
IC50 = 64000 nM
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[20] | |||
| Compound Name |
1,3-Diamino-6,7-dimethoxy-9H-xanthene-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706770
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| Activity |
IC50 = 64800 nM
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[21] | |||
| Compound Name |
3-[[(1R)-1-Cyclohexylethyl]amino]-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466701; 3-{[(1R)-1-Cyclohexylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione; SCHEMBL4378531; BDBM50259380
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| Activity |
IC50 = 65000 nM
|
[24] | |||
| Compound Name |
2,4-Diamino-10-methyl-5,10-dihydro-benzo[b][1,8]naphthyridine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360278; SCHEMBL6207348; BDBM50162650; 2,4-diamino-10-methyl-5H-benzo[b][1,8]naphthyridine-3-carbonitrile
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| Activity |
IC50 = 70000 nM
|
[21] | |||
| Compound Name |
((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-5,8-diaza-benzo[a]azulen-3-yloxy)-acetic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL559881; BDBM50297147
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| Activity |
IC50 = 78000 nM
|
[25] | |||
| Compound Name |
3-(Pyridin-4-ylamino)-4-{[1-(1,3-thiazol-2-yl)ethyl]-amino}cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL467729; SCHEMBL4375931; BDBM50259478
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| Activity |
IC50 = 81000 nM
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[24] | |||
| Compound Name |
2-[[7-(4-Ethoxyanilino)-6-methylpyrazolo[1,5-a]pyrimidin-5-yl]amino]ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163977; BDBM50395298
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| Activity |
IC50 = 83000 nM
|
[26] | |||
| Compound Name |
5-Hydroxyisoquinoline
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Investigative | Compound Info | ||
| Synonyms |
Isoquinolin-5-ol; 5-Isoquinolinol; 5-Hydroxy-isoquinoline; MFCD00006906; CHEMBL57481; MLS000737285; 5-Hydroxyisoquinoline, 90%, technical; NSC51787; PubChem12826; ACMC-2097ay; Oprea1_051337; SCHEMBL276518; CTK1A6688; KS-00000DJX; HMS1618B04; HMS2748D05; ZINC404427; ACN-S004708; ACT10629; EINECS 219-456-9; ANW-13736; BBL027623; BDBM50240538; NSC 51787; NSC-51787; STK833029; AKOS005259348; CS-W004721; MCULE-8624924478; NCGC00246945-01; AK-24783; BR-24783; DS-10757; SMR000035084; SY021130; AI3-61885; DB-029159; 5-Hydroxyisoquinoline, technical grade, 90%; AM20050993; FT-0634280; ST50823965; A23336; A26441; S-1885; 578H676; J-015489; J-517944; Q27455996
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| Activity |
IC50 = 85000 nM
|
[27] | |||
| Compound Name |
2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid; 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE-1-CARBOXYLIC ACID; NSC629423; CHEMBL246101; DL-1,2,3,4-Tetrahydronorharmane-1-carboxylic acid; 2,3,4,9-Tetrahydro-1H-pyrido(3,4-b)indole-1-carboxylic acid; 2,3,4,9-tetrahydro-1H-b-carboline-1-carboxylic acid; 1H-Pyrido(3,4-b)indole-1-carboxylic acid, 2,3,4,9-tetrahydro-; 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2,3,4,9-tetrahydro-; SCHEMBL1491320; SCHEMBL12395388; CTK8F2841; DTXSID40904174; ALBB-028776; CS-B1226; BBL008156; BDBM50215516; MFCD00227826; STK894014; AKOS005144353; NSC-629423; NCI60_009530; NCI60_016439; ST054350; VS-01838; AB0151549; tetrahydro-beta-carboline-1-carboxylic acid; FT-0674975; T8090; 1,2,3,4-tetrahydrobeta-carbolinecarboxylic acid; 1,2,3,4-Tetrahydro--carboline-1-carboxylic Acid; 1,2,3,4-tetrahydropyrido[3,4-b]indole-1-carboxylic acid; 2,3,4,9-tetrahydro-1 H-beta-carboline-1-carboxylic acid; 2,3,4,9-Tetrahydro-1H-.beta.-carboline-1-carboxylic acid; 1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid, AldrichCPR; 1H,2H,3H,4H,9H-PYRIDO[3,4-B]INDOLE-1-CARBOXYLIC ACID; 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium-1-carboxylate
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| Activity |
IC50 = 87000 nM
|
[20] | |||
| Compound Name |
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
Cyanoquinoline, 44; BMCL193485 Compound 3a; CHEMBL230761; SCHEMBL2278592; BDBM21933
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| Activity |
IC50 = 87100 nM
|
[22] | |||
| Compound Name |
N-Hydroxy-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248312; SCHEMBL6241157; BDBM50215499
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| Activity |
IC50 = 88000 nM
|
[20] | |||
| Compound Name |
3-(Benzylamino)-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466700; SCHEMBL4375983; BDBM50259378
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[24] | |||
| Compound Name |
4-[[7-(4-Ethoxyanilino)-6-methylpyrazolo[1,5-a]pyrimidin-5-yl]amino]cyclohexan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163980; BDBM50395302
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[26] | |||
| Compound Name |
25-Hydroxy-13(24),15,17-cheilanthatrien-19,25-olide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478798; BDBM50269815
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[28] | |||
| Compound Name |
25-Hydroxy-13(24),17-cheilanthadien-16,19-olide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515940; BDBM50269821
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[28] | |||
| Compound Name |
13,16-Epoxy-25-hydroxy-17-cheilanthen-19,25-olide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476478; BDBM50269820
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[28] | |||
| Compound Name |
3-[2-[(1R,4Ar,4bS,8aS,10aS)-4b,8,8,10a-tetramethyl-2-methylidene-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476479; 16,25-dihydroxy-13(24),17-cheilanthadien-19,25-olide; BDBM50269822
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[28] | |||
| Compound Name |
N-((3-Amino-6-chloropyrazin-2-yl)methylcarbamothioyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783556; BDBM50345825
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[5] | |||
| Compound Name |
7-N-(3-Chloro-4-fluorophenyl)-5-N-[4-(diethylamino)cyclohexyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163988; BDBM50395309
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
7-N-(3-Chloro-4-fluorophenyl)-5-N-(piperidin-4-ylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163982; BDBM50395304
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
1,3-Diamino-6,8-dihydroxy-9H-xanthene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706777
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3-[(2-Chloropyridin-4-yl)amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468321; 3-[(2-Chloropyridin-4-yl)amino]-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione; SCHEMBL4371397; BDBM50259599; (r)-3-(2-chloropyridin-4-ylamino)-4-(1-phenylethylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-[4-[[7-(3-Chloro-4-fluoroanilino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]cyclohexyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163987; BDBM50395308
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Unii-O5YT36mst0
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
EF-24; O5YT36MST0; CHEMBL379849; SCHEMBL8119310; BDBM50431030; ZINC34009101; EF-24, >=98% (HPLC); 3,5-bis(2-flurobenzylidene) piperidin-4-one; (3E,5E)-3,5-Bis((2-fluorophenyl)methylene)-4-piperidinone; 4-Piperidinone, 3,5-bis((2-fluorophenyl)methylene)-, (3E,5E)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
1,3,7-Triamino-9H-xanthene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706774
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
1,3-Diamino-9H-xanthene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706775
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-N-(4-Aminophenyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163983; BDBM50395305
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489058; SCHEMBL4128607; SCHEMBL4128610; BDBM50274385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
5-N-(3-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163986; BDBM50395307
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-[Methyl(pyridin-4-yl)amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467913; 3-[Methyl(pyridin-4-yl)amino]-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione; SCHEMBL4375394; BDBM50259566
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
3-[[(1R)-1-Phenylethyl]amino]-4-(pyrimidin-4-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512454; 3-{[(1R)-1-Phenylethyl]amino}-4-(pyrimidin-4-ylamino)cyclobut-3-ene-1,2-dione; SCHEMBL4371264; BDBM50259568
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(3S)-3-[[7-(4-Ethoxyanilino)-6-methylpyrazolo[1,5-a]pyrimidin-5-yl]amino]piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163626; BDBM50395296
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-{[(1R)-1-Phenylethyl]amino}-4-(1H-pyrazol-3-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524472; SCHEMBL4368082; BDBM50259598; 3-[[(1R)-1-phenylethyl]amino]-4-(1H-pyrazol-5-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338335; BDBM50431025
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338334; BDBM50431026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(R)-3-(1-Phenylethylamino)-4-(pyridin-3-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505335; BDBM50259567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
1-Naphthol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
naphthalen-1-ol; 1-Naphthalenol; alpha-naphthol; 1-Hydroxynaphthalene; NAPHTHOL; Fouramine ERN; Fourrine ERN; Tertral ERN; Furro ER; Basf Ursol ERN; Ursol ERN; Fourrine 99; Nako TRB; Zoba ERN; Durafur developer D; alpha-Hydroxynaphthalene; Naphthalenol; C.I. Oxidation Base 33; .alpha.-Naphthol; 1-Naphthyl alcohol; NSC 9586; C.I. 76605; CCRIS 1172; CI Oxidation Base 33; HSDB 2650; .alpha.-Hydroxynaphthalene; EINECS 201-969-4; UNII-2A71EAQ389; CI 76605; AI3-00106; MFCD00003930; WLN: L66J BQ; CHEMBL122617; SGCUT00118; NSC9586; 2A71EAQ389; to_000072; LS-95401; 1-Naphthol, 99+%; DSSTox_CID_1793; C11714; DSSTox_RID_76330; DSSTox_GSID_21793; AB-131/40232333; 1-napthol; Naphthol-1; Naphthyl-1-ol; alpha-Naphthyl alcohol; napthalenol; alpha naphthol; alpha-napthol; napthyl alcohol; hydroxynaphthalene; naphthalene-1-ol; Naphthol 1; 1-Naphtol; 8 -naphthol; hydroxy naphthalene; (+)-naphthol; nchembio791-comp4; 1-Naphthol, Reagent; 1-Naphthol, Purified; Naphth-1-ol, 9; PubChem16938; ACMC-20ait6; SCHEMBL3416; alpha-Naphthol, 1-Naphthol; KSC179K6D; 33420_RIEDEL; 35825_RIEDEL; N1000_SIAL; N2780_SIAL; 1-Naphthol, Pure PA, 99%; 1-Naphthol, LR, >=99%; DTXSID6021793; 70438_FLUKA; 70442_FLUKA; BDBM23450; CTK0H9561; 1-Naphthol, BioXtra, >=99%; 1-Naphthol, p.a., 99.0%; ACT07473; HY-Y1309; NSC-9586; ZINC4292977; Tox21_202120; Tox21_302768; 1-Naphthol, >=98.0% (GC); ANW-75304; BBL011611; SBB040845; STL163337; ZINC00967929; AKOS000118822; CS-W020125; EBD2205191; GS-6917; MCULE-2825050946; QC-1267; 1-Naphthol, ReagentPlus(R), >=99%; Duloxetine EP Impurity D (1-Naphthol); NCGC00249169-01; NCGC00256563-01; NCGC00259669-01; AK-44442; ST5214429; 1-Naphthol, SAJ special grade, >=99.0%; 1-Naphthol, Vetec(TM) reagent grade, 98%; FT-0608111; N0026; N0864; ST50214429; 1-Naphthol, PESTANAL(R), analytical standard; M-5886; A843458; Q408876; J-610055; F1908-0108; Z1262254359
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
3-{Methyl[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467912; SCHEMBL4539537; BDBM50259565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
7-N-(3-Chloro-4-fluorophenyl)-5-N-cyclohexylpyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163990; BDBM50395311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-{[(1S)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512784; SCHEMBL4368075; BDBM50259377; 3-[[(1S)-1-phenylethyl]amino]-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-(4-Morpholinophenyl)-6-phenylquinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1209832; BDBM50323617
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[31] | |||
| Compound Name |
N-(4-Chloro-2-fluorophenyl)-6-(4-chlorophenyl)quinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1208887; BDBM50323629
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[31] | |||
| Compound Name |
6-Methoxy-1-(2H-tetrazol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248313; SCHEMBL6353220; BDBM50215521
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[20] | |||
| Compound Name |
Phaeochromycin C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487191; BDBM50241927; 5-[(4-hydroxy-6-oxopyran-2-yl)methyl]-2-propylchromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[32] | |||
| Compound Name |
2-Benzyl-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248164; SCHEMBL6241878; BDBM50215484; 2-benzyl-6-methoxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[20] | |||
| Compound Name |
8-Chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-cyclobutylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501709; SCHEMBL4959879; BDBM29926; substituted 6-aminoquinoline-3-carbonitrile, 37
Click to Show/Hide
|
||||
| Activity |
IC50 = 131000 nM
|
[23] | |||
| Compound Name |
2-Isopropyl-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437766; SCHEMBL6239882; BDBM50215527; 6-methoxy-2-propan-2-yl-1,3,4,9-tetrahydropyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[20] | |||
| Compound Name |
6-Acetoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437554; SCHEMBL6241595; BDBM50215515; 6-acetyloxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 37 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GNF-PF-2857
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GNF-PF-2857; CHEMBL217665; ChemDiv1_019259; N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine; N-[4-(4-methylpiperazin-1-yl)phenyl]quinolin-4-amine; AC1NCZHO; Oprea1_484208; SCHEMBL7129284; HMS641L09; ZINC1507915; BDBM50196110; AKOS024359777; MCULE-1778420008; ST50989409; [4-(4-methylpiperazinyl)phenyl]-4-quinolylamine; SR-01000394477; SR-01000394477-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
(6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245705; SCHEMBL6240399; BDBM50215514
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
6-Methoxy-1-methyl-2,3,4,9-tetrahydropyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396151; SCHEMBL6245939; .beta.-Carboline, 1,2,3,4-tetrahydro-1-carboxy-6-methoxy-1-methyl-; BDBM50215526; 6-Methoxy-1-methyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid #; 6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-(4-(4-(4-Methylpiperazin-1-yl)phenylamino)quinolin-6-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1209009; BDBM50323637
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
3-((Dimethylamino)methyl)-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245461; 3-[(dimethylamino)methyl]-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid; SCHEMBL6359825; BDBM50215494
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
6-Methoxy-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245503; BDBM50215509
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
1,3-Diamino-6-hydroxy-9-phenyl-9H-xanthene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706787
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[tert-butyl(2-hydroxyethyl)amino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL271190
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
N-[4-(4-Methylpiperazin-1-yl)phenyl]-6-thiophen-2-ylquinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1208949; SCHEMBL4154839; BDBM50323633; n-(4-(4-methylpiperazin-1-yl)phenyl)-6-(thiophen-2-yl)quinolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-Methoxy-9H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL280224; BDBM50215496; 6-Methoxy-beta-carboline-1-carboxylic acid; 6-Methoxy-9H-beta-carboline-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
1,3-Bis(ethylamino)-6,7-dihydroxy-9H-xanthene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706772
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
6-Methoxy-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245502; SCHEMBL11736040; BDBM50215507; 6-methoxy-1,2,3,4-tetrahydrocarbazole-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
2,4-Diamino-10,10-dioxo-5H-thiochromeno[2,3-b]pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180574; SCHEMBL6207864; BDBM50162642; 2,4-Diamino-10,10-dioxo-5,10-dihydro-10lambda*6*-thiochromeno[2,3-b]pyridine-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
2,4-Diamino-5H-thiochromeno[2,3-b]pyridine-3-carbonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL178952; SCHEMBL6207476; BDBM50162644
Click to Show/Hide
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| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
6-Methoxy-5-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL247344; SCHEMBL6237401; BDBM50215490
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N,6-Diphenylquinolin-4-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1209750; BDBM50323614
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-Methoxy-9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248512; SCHEMBL6239283; BDBM50215487; 6-methoxy-9-methyl-1,2,3,4-tetrahydropyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
6-Methoxy-3-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397330; SCHEMBL6240876; BDBM50215495
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
6-Bromo-N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1208948; SCHEMBL13905989; BDBM50323632
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245704; SCHEMBL6239836; BDBM50215500
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Substituted 6-aminoquinoline-3-carbonitrile, 36
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523059; BDBM29925
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
8-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395409; SCHEMBL6243318; BDBM50215519
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(1E,4S,4Ar,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL410643; ZINC29134475; WAY-266176
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[33] | |||
| Compound Name |
(6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395133; SCHEMBL5541281; BDBM50215486
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247342; SCHEMBL6239907; BDBM50215493
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-(1-propylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl}amino)quinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL495617; SCHEMBL4959910; BDBM29924; substituted 6-aminoquinoline-3-carbonitrile, 35
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
Methyl 6-methoxy-9H-pyrido[3,4-b]indole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396163; SCHEMBL16798220; BDBM50215518
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
1,3-Diamino-6-methoxy-9-phenyl-9H-xanthene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706780
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
2-(6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248511; ChemDiv3_014842; Oprea1_625701; SCHEMBL6237686; HMS1515C14; BDBM50215505; STL530332; AKOS001680836; MCULE-5658712604; ST048549; SR-01000150442; SR-01000150442-1; 2-(6-methoxy-1,2,3,4-tetrahydrobeta-carbolinyl)acetic acid; (6-methoxy-2,3,4,9-tetrahydro-1h-beta-carbolin-1-yl)acetic acid; (6-Methoxy-2,3,4,9-tetrahydro-1H-.beta.-carbolin-1-yl)acetic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)-7-N-methylpyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163622; BDBM50395294
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||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
5-N-(4-Aminocyclohexyl)-2-tert-butyl-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163998; BDBM50395312
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine-5,7-diamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164000; BDBM50395313
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||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
6-(2-Morpholinoethylamino)-4-(4-phenoxyphenylamino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL371095; SCHEMBL4773967; BDBM50173837; 6-(2-morpholin-4-ylethylamino)-4-(4-phenoxyanilino)-1,7-naphthyridine-3-carbonitrile; 6-[(2-morpholin-4-ylethyl)amino]-4-[(4-phenoxyphenyl)amino]-[1,7]naphthyridine-3-carbonitrile; 6-[(2-morpholin-4-ylethyl)amino]-4-[(4-phenoxyphenyl)amino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[4] | |||
| Compound Name |
6-(2-Morpholinoethylamino)-4-(4-(phenylthio)phenylamino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199210; SCHEMBL4769813; BDBM50173833; 6-(2-morpholin-4-ylethylamino)-4-(4-phenylsulfanylanilino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
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||||
| Activity |
IC50 > 400000 nM
|
[4] | |||
| Compound Name |
4-(4-Benzylphenylamino)-6-(2-morpholinoethylamino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371658; SCHEMBL4772416; BDBM50173838; 4-(4-benzylanilino)-6-(2-morpholin-4-ylethylamino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[4] | |||
| Compound Name |
4-(3-Chloro-4-fluoro-phenylamino)-6-(2-morpholin-4-yl-ethylamino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197538; SCHEMBL4767030; BDBM29896; 1,7-naphthyridine-3-carbonitrile, 1; 4-(3-chloro-4-fluoroanilino)-6-(2-morpholin-4-ylethylamino)-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
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||||
| Activity |
IC50 > 400000 nM
|
[4] | |||
| Compound Name |
Tpl2-IN-I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261238; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-1,7-naphthyridine; SCHEMBL2369875; BDBM50375665; 4-(3-chloro-4-fluoroanilino)-6-[methyl(pyridin-3-yl)amino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
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||||
| Activity |
IC50 = 110000000 nM
|
[34] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61. | ||||
| REF 2 | Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)py... J Med Chem. 2008 Oct 9;51(19):5897-900. | ||||
| REF 3 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. | ||||
| REF 4 | Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. | ||||
| REF 5 | Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2009 Jun 15;19(12):3238-42. | ||||
| REF 6 | Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance. J Med Chem. 2010 Feb 11;53(3):1238-49. | ||||
| REF 7 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 8 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 9 | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2000-7. | ||||
| REF 10 | Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6575-7. | ||||
| REF 11 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 12 | Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. | ||||
| REF 13 | Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1722-5. | ||||
| REF 14 | Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. | ||||
| REF 15 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 16 | Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. | ||||
| REF 17 | Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. | ||||
| REF 18 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 19 | 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization. Bioorg Med Chem Lett. 2010 Jan 1;20(1):334-7. | ||||
| REF 20 | Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2007 Aug 15;17(16):4657-63. | ||||
| REF 21 | Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2005 Mar 15;15(6):1587-90. | ||||
| REF 22 | Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles. J Med Chem. 2007 Sep 20;50(19):4728-45. | ||||
| REF 23 | Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8. | ||||
| REF 24 | Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. | ||||
| REF 25 | Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4878-81. | ||||
| REF 26 | Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. J Med Chem. 2012 Aug 9;55(15):6700-15. | ||||
| REF 27 | Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects. J Med Chem. 2008 Oct 9;51(19):6225-9. | ||||
| REF 28 | Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia. J Nat Prod. 2001 Mar;64(3):300-3. | ||||
| REF 29 | Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. J Med Chem. 2013 May 9;56(9):3456-66. | ||||
| REF 30 | 4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors. Bioorg Med Chem. 2008 Oct 15;16(20):9202-11. | ||||
| REF 31 | 4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2). Bioorg Med Chem Lett. 2010 Aug 15;20(16):4738-40. | ||||
| REF 32 | Phaeochromycins A-E, anti-inflammatory polyketides isolated from the soil actinomycete Streptomyces phaeochromogenes LL-P018. J Nat Prod. 2005 Aug;68(8):1262-5. | ||||
| REF 33 | Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. | ||||
| REF 34 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | ||||
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