Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81905 | Target Info | |||
| Target Name | Histamine receptor (HR) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 63 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ergotidine
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|
Approved | Compound Info | ||
| Synonyms |
Eramin; Ergamine; Histamine; Histaminum; Istamina; Theramine; Free histamine; Histamine Base; Histamine [USAN]; Istamina [Italian]; H7125_SIGMA; [3H]histamine; ALBB-005968; Beta-Aminoethylglyoxaline; Beta-Aminoethylimidazole; Beta-aminothethylglyoxaline; Histamine (DCF); Histamine, Free Base; Histaminum (TN); L-histamine; ZERO/004089; Imidazole-4-ethylamine; Beta-Imidazolyl-4-ethylamine; F411C768-A159-4FC0-A195-291A08BB03AA; 1H-Imidazole-4-ethanamine; 1H-Imidazole-5-ethanamine; 2-(1H-Imidazol-4-yl)ethanamine; 2-(1H-imidazol-4-yl)ethan-1-amine; 2-(1H-imidazol-5-yl)ethanamine; 2-(3H-Imidazol-4-yl)-ethylamine; 2-(4-Imidazolyl)ethylamine; 2-Imidazol-4-ylethylamine; 2-[4-Imidazolyl]ethylamine; 4-(2-Aminoethyl)-1H-imidazole; 4-Imidazoleethylamine; 5-Imidazoleethylamine
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|
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| Activity | Histamine H2 receptor |
Ki = 50118.72 nM
|
[1] | ||
| Compound Name |
Orphenadrine
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|
Approved | Compound Info | ||
| Synonyms |
Antiflex; Biorphen; Brocadisipal; Brocasipal; Disipal; Lysantin; Mefenamine; Mephenamine; Methyldiphenylhydramine; Myolin; Myotrol; ORP; Orfenadrina; Orfro; Orphenadine; Orphenadinum; Orphenadrin; Orphenadrinum; Orphenate; Orphenedrine; Norflex Orphenadrine Citrate; Sodium Mefenamine; WS 2434; Banflex (TN); Biorphen (TN); Brocasipal (TN); Disipal (TN); Flexon (TN); Mephenamin (TN); Mialgin (TN); Norflex (TN); O-Methyldiphenhydramine; O-Monomethyldiphenhydramine; Orfenadrina [INN-Spanish]; Orphenadrine(INN); Orphenadrine [INN:BAN]; Orphenadrinum [INN-Latin]; Beta-Dimethylaminoethyl 2-methylbenzhydryl ether; Phenyl-o-tolylmethyl dimethyaminoethyl ether; Beta-Dimethylaminoethyl-2-methylbenzhydryl ether; N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamin; N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine; N,N-dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine; N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine; N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyl)oxy)ethylamine; N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine; N,N-dimethyl-2-{[(2-methylphenyl)(phenyl)methyl]oxy}ethanamine; 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine; 2-Methyldiphenhydramine
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|
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| Activity | Histamine H1 receptor |
IC50 = 97723.72 nM
|
[2] | ||
| Compound Name |
Pitolisant
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|
Approved | Compound Info | ||
| Synonyms |
Pitolisant; 362665-56-3; TIPROLISANT; BF2.649; UNII-4BC83L4PIY; 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine; Pitolisant (BF2.649); 1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine; 4BC83L4PIY; Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-; CHEMBL462605; wakix; 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride; 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine; Tirolisant; Pitolisant (INN); tiprolisant [USAN]; Wakix (TN); Pitolisant [USAN:INN]; SCHEMBL117648; GTPL8924; CTK1B6404; HBS-101
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|
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| Activity | Histamine H4 receptor |
Ki ~ 100000 nM
|
[3] | ||
| Compound Name |
Fentanyl
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|
Approved | Compound Info | ||
| Synonyms |
fentanyl; Fentanil; Phentanyl; Fentora; Sublimaze; Fentanila; Fentanest; Duragesic; Fentanylum; Durogesic; Sentonil; 437-38-7; Duragesic-100; IONSYS; Duragesic-25; Duragesic-75; Duragesic-50; Duragesic-12; Fentanyl-25; Fentanyl-75; Fentanyl-12; Fentanyl-50; Fentanylum [INN-Latin]; Fentanila [INN-Spanish]; Fentanyl-100; 1-Phenethyl-4-N-propionylanilinopiperidine; Matrifen; Sublimase; N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide; N-(1-Phenethyl-4-piperidyl)propionanilide; N-Phenethyl-4-(N-propionylanilino)piperidine; Fentanil [DCIT]; Subsys; Fentanyl-37; Fentanyl-62; Fentanyl-87; Abstral; Actiq; Lazanda; Onsolis; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Sublimaze Preservative Free; fentanyl (transmucosal film, pain), Auxilium Pharmaceuticals
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|
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| Activity | Histamine H1 receptor |
IC50 = 147910.84 nM
|
[2] | ||
| Compound Name |
A-304121
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|
Investigative | Compound Info | ||
| Synonyms |
A304121; A 304121
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|
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| Activity | Histamine H1 receptor |
Ki = 69183.1 nM
|
[4] | ||
| Histamine H2 receptor |
Ki = 70794.58 nM
|
[4] | |||
| Compound Name |
6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468176; BDBM50261729
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|
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| Activity | Histamine H1 receptor |
IC50 ~ 50000 nM
|
[5] | ||
| Compound Name |
1-{4-[3-((S)-3-Amino-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319231; BDBM50119696; 4'-[3-[(3S)-3beta-Aminopyrrolizino]propoxy]acetophenone
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|
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| Activity | Histamine H2 receptor |
Ki = 50000 nM
|
[6] | ||
| Histamine H1 receptor |
Ki = 90000 nM
|
[6] | |||
| Compound Name |
2-(3,4-Dichlorophenyl)-1H-imidazole-4-ethaneamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154068; BDBM50422505
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|
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| Activity | Histamine H1 receptor |
IC50 = 50118.72 nM
|
[7] | ||
| Compound Name |
Tert-butyl (2R)-2-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64120; BDBM50220451
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|
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| Activity | Histamine H2 receptor |
Ki = 50118.72 nM
|
[4] | ||
| Compound Name |
Cyclopropyl(4-(3-(4-((2r)-2-(isopropylamino)propanoyl)-1-piperazinyl)propoxy)phenyl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304888; SCHEMBL7245321; BDBM50220460
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|
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| Activity | Histamine H2 receptor |
Ki = 50118.72 nM
|
[4] | ||
| Compound Name |
(4-(3-(4-((2s)-2-Aminopropanoyl)-1-piperazinyl)propoxy)phenyl)(cyclopropyl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62804; SCHEMBL7248482; BDBM50220431; PDSP1_001278; PDSP2_001262; (2S)-2-amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]propan-1-one
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|
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| Activity | Histamine H1 receptor |
Ki = 53703.18 nM
|
[4] | ||
| Compound Name |
Cyclopropyl-[4-[3-[4-[(2R)-pyrrolidine-2-carbonyl]piperazin-1-yl]propoxy]phenyl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64461; BDBM50220442
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|
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| Activity | Histamine H2 receptor |
Ki = 53703.18 nM
|
[4] | ||
| Compound Name |
1-Cyclohexyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024391; BDBM50382864
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|
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| Activity | Histamine H3 receptor |
IC50 = 53800 nM
|
[8] | ||
| Compound Name |
N,N-Dimethyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroisoquinolin-6-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2031874; SCHEMBL3808157; BDBM50383153
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|
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| Activity | Histamine H2 receptor |
Ki ~ 55000 nM
|
[9] | ||
| Compound Name |
(1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103828; BDBM50119726
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|
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| Activity | Histamine H1 receptor |
Ki = 56000 nM
|
[6] | ||
| Compound Name |
4-[3-(4-Propionylphenoxy)propyl]-1-piperazinecarboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62066; BDBM50220142
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|
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| Activity | Histamine H2 receptor |
Ki = 56234.13 nM
|
[10] | ||
| Compound Name |
4-[3-[4-(4-Pyridinyl)phenoxy]propyl]piperazine-1-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419912
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|
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| Activity | Histamine H2 receptor |
Ki = 57543.99 nM
|
[11] | ||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-4,4-dimethylpentan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59931; SCHEMBL7245253; BDBM50220438
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|
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| Activity | Histamine H2 receptor |
Ki = 57543.99 nM
|
[4] | ||
| Compound Name |
2-[2-(3H-Imidazol-4-yl)-ethyl]-pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310360; CTK4I9661; DTXSID30458656; AKOS015839560
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|
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| Activity | Histamine H4 receptor |
EC50 = 58884.37 nM
|
[12] | ||
| Compound Name |
N-(3-Bromo-4-(2-morpholinoethoxy)phenethyl)-1H-pyrrole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563666; BDBM50293614
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|
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| Activity | Histamine H3 receptor |
IC50 = 59200 nM
|
[13] | ||
| Compound Name |
((S)-1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320174; BDBM50119718
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|
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| Activity | Histamine H1 receptor |
Ki = 60000 nM
|
[6] | ||
| Compound Name |
1-[4-[3-[4-(Pyridine-3-carbonyl)piperazin-1-yl]propoxy]phenyl]hexan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418658; BDBM50220406
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|
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| Activity | Histamine H2 receptor |
Ki = 60255.96 nM
|
[10] | ||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]pentan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291821; BDBM50220434
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|
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| Activity | Histamine H2 receptor |
Ki = 60255.96 nM
|
[4] | ||
| Compound Name |
4-[4-(Dimethylamino)phenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290583; BDBM50021558
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|
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| Activity | Histamine H4 receptor |
Ki = 64490 nM
|
[14] | ||
| Compound Name |
4'-(3-Pyrrolizinopropoxy)biphenyl-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25688
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|
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| Activity | Histamine H2 receptor |
Ki = 67608.3 nM
|
[11] | ||
| Compound Name |
6-(4-Fluorophenyl)-7-methyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314768; BDBM50424317
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|
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| Activity | Histamine H4 receptor |
Ki = 67870 nM
|
[15] | ||
| Compound Name |
Ethyl 4-[3-[4-(1H-imidazol-5-yl)phenoxy]propyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104947
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|
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| Activity | Histamine H2 receptor |
Ki = 69183.1 nM
|
[11] | ||
| Compound Name |
Ethyl 4-[3-[4-(3-methylbutanoyl)phenoxy]propyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61231; BDBM50220107
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|
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| Activity | Histamine H2 receptor |
Ki = 69183.1 nM
|
[10] | ||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302829; SCHEMBL7253301; BDBM50220430
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|
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| Activity | Histamine H1 receptor |
Ki = 70794.58 nM
|
[4] | ||
| Histamine H2 receptor |
Ki = 100000 nM
|
[4] | |||
| Compound Name |
N-[(4-Methoxyphenyl)methyl]-2-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754008; BDBM50137643
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|
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| Activity | Histamine H4 receptor |
Ki = 72443.6 nM
|
[16] | ||
| Compound Name |
(3R)-3-Amino-4-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-4-oxobutanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64124; BDBM50220454
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| Activity | Histamine H2 receptor |
Ki = 72443.6 nM
|
[4] | ||
| Compound Name |
N-(3-Bromo-4-(2-morpholinoethoxy)phenethyl)-5-bromofuran-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559448; BDBM50293629
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|
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| Activity | Histamine H3 receptor |
IC50 = 73200 nM
|
[13] | ||
| Compound Name |
((S)-1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316968; BDBM50119715
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| Activity | Histamine H1 receptor |
Ki = 75000 nM
|
[6] | ||
| Compound Name |
(2R)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2beta-methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107877; BDBM50474239
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| Activity | Histamine H4 receptor |
EC50 = 75857.76 nM
|
[17] | ||
| Compound Name |
Ethyl 1-[2-[4-(phenylcarbamoylsulfamoyl)phenoxy]ethyl]piperidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024394; BDBM50382867
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| Activity | Histamine H3 receptor |
IC50 = 77900 nM
|
[8] | ||
| Compound Name |
(+)-(S)-N,N-Dimethyl-2-(3-(1-(pyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091778; SCHEMBL4852438; BDBM50314267; N,N-dimethyl-2-[3-[(1S)-1-pyridin-3-ylethyl]-1-benzothiophen-2-yl]ethanamine
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| Activity | Histamine H1 receptor |
Ki = 79000 nM
|
[18] | ||
| Compound Name |
Ethyl 4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62948; BDBM50220403
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| Activity | Histamine H2 receptor |
Ki = 79432.82 nM
|
[10] | ||
| Compound Name |
1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-(methylamino)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60401; BDBM50220422
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| Activity | Histamine H2 receptor |
Ki = 79432.82 nM
|
[4] | ||
| Histamine H1 receptor |
Ki = 100000 nM
|
[4] | |||
| Compound Name |
(1-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL102390; BDBM50119700
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| Activity | Histamine H1 receptor |
Ki = 80000 nM
|
[6] | ||
| Histamine H2 receptor |
Ki = 100000 nM
|
[6] | |||
| Compound Name |
1-[4-(2-Piperidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024393; BDBM50382866
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| Activity | Histamine H3 receptor |
IC50 = 82000 nM
|
[8] | ||
| Compound Name |
1-[4-[3-[4-(Methylsulfonyl)piperazino]propoxy]phenyl]-1-hexanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431172; BDBM50220103
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| Activity | Histamine H2 receptor |
Ki = 83176.38 nM
|
[10] | ||
| Compound Name |
4-[3-[4-[N-(Tert-Butoxycarbonyl)-D-alanyl]piperazino]propoxy]phenylcyclopropyl ketone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64406; BDBM50220417
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| Activity | Histamine H2 receptor |
Ki = 83176.38 nM
|
[4] | ||
| Compound Name |
6-(4-Fluorophenyl)-4-piperazin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314497; BDBM50424331
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| Activity | Histamine H3 receptor |
Ki = 84660 nM
|
[15] | ||
| Compound Name |
(2S)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2alpha-methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319658; BDBM50474246
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| Activity | Histamine H4 receptor |
EC50 = 85113.8 nM
|
[17] | ||
| Compound Name |
1-Phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024385; BDBM50382858
Click to Show/Hide
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| Activity | Histamine H3 receptor |
IC50 = 88600 nM
|
[8] | ||
| Compound Name |
1-[4-[3-[4-(Cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-2-[(2R)-pyrrolidin-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60435; BDBM50220433
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| Activity | Histamine H2 receptor |
Ki = 89125.09 nM
|
[4] | ||
| Histamine H1 receptor |
Ki = 95499.26 nM
|
[4] | |||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1H-imidazol-5-yl)propan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL61792; BDBM50220437
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| Activity | Histamine H2 receptor |
Ki = 89125.09 nM
|
[4] | ||
| Histamine H1 receptor |
Ki = 95499.26 nM
|
[4] | |||
| Compound Name |
N-[(3S)-1-[3-[4-(Cyclopropylcarbonyl)phenoxy]propyl]pyrrolidine-3beta-yl]-1-methyl-1H-imidazole-4-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322678; BDBM50119698
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| Activity | Histamine H1 receptor |
Ki = 91000 nM
|
[6] | ||
| Compound Name |
Ethyl 1-[3-[4-(phenylcarbamoylsulfamoyl)phenoxy]propyl]piperidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021969; BDBM50382876
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| Activity | Histamine H3 receptor |
IC50 = 91100 nM
|
[8] | ||
| Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024392; BDBM50382865
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| Activity | Histamine H3 receptor |
IC50 = 93600 nM
|
[8] | ||
| Compound Name |
(2R)-2-Amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-(1,3-thiazol-2-yl)propan-1-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL59733; BDBM50220461
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||||
| Activity | Histamine H2 receptor |
Ki = 97723.72 nM
|
[4] | ||
| Histamine H1 receptor |
Ki = 100000 nM
|
[4] | |||
| Compound Name |
4-[3-[4-(3-Thienyl)phenoxy]propyl]piperazine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105567
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 97723.72 nM
|
[11] | ||
| Compound Name |
3-(1H-Imidazol-5-yl)propyl N-(3-phenoxypropyl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413360; BDBM50492995
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki ~ 100000 nM
|
[19] | ||
| Compound Name |
3-(1H-Imidazol-5-yl)propyl N-(4-phenoxybutyl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413361; BDBM50492984
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki ~ 100000 nM
|
[19] | ||
| Compound Name |
4-[3-(4'-Methoxy-4-biphenylyloxy)propyl]piperazine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105483
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 100000 nM
|
[11] | ||
| Compound Name |
6-(4-Fluorophenyl)-N,7-dimethyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314769; BDBM50424316
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki ~ 100000 nM
|
[15] | ||
| Compound Name |
1H-Indol-2-yl-[4-[2-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-methylamino]ethyl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910381; BDBM50419326
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
1-Cyano-3-[[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106570; BDBM50474243
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
4-[3-(4-beta-Alanylpiperazino)propoxy]phenylcyclopropyl ketone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61120; BDBM50220468; L021800
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 100000 nM
|
[4] | ||
| Compound Name |
1H-Indol-2-yl-[4-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910378; BDBM50419329
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
EC50 = 104712.85 nM
|
[20] | ||
| Compound Name |
1-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024388; BDBM50382861
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 = 107000 nM
|
[8] | ||
| Compound Name |
Adiphenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Trasentine; Spasmolytin; Adiphenin; Difacil; Diphacil; Diphacyl; Tranzetil; Trasentin; Patrovine; Transentine; Vegantine; Trazentyna; Wegantyna; SKF 962A; Diphenylacetyldiethylaminoethanol; 2-Diethylaminoethyl diphenylacetate; Diphenylacetic acid diethylaminoethyl ester; UNII-YKG6OR043Q; 2-(Diethylamino)ethyl diphenylacetate; 2-(diethylamino)ethyl 2,2-diphenylacetate; Diphenylacetic acid, 2-(diethylamino)ethyl ester; YKG6OR043Q; Acetic acid, diphenyl-, 2-(diethylamino)ethyl ester; 2-Diethylaminoethylester kyseliny difenyloctove; Benzeneacetic acid, .alpha.-phenyl-, 2-(diethylamino)ethyl ester; Benzeneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester, (9CI); Adiphenine [INN]; Wegantyna [Polish]; Trazentyna [Polish]; Adipheninum; Adifenina; Adifenina [INN-Spanish]; Adipheninum [INN-Latin]; NSC129224; HSDB 3282; EINECS 200-599-0; BRN 1887268; Benzeneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester; Diphenylessigsaeure-beta-diethylaminoethylester; Acetic acid, diphenyl-, 2-(diethylamino)ester; Diphenylacetic acid 2-(diethylamino)ethyl ester; 2-Diethylaminoethylester kyseliny difenyloctove [Czech]; 2-diethylaminoethyl 2,2-diphenylacetate; Ester dwuetyloaminoetylowy kwasu dwufenylooctowego [Polish]; Spectrum_001316; Prestwick0_000075; Prestwick1_000075; Prestwick2_000075; Prestwick3_000075; Spectrum2_001517; Spectrum3_000954; Spectrum4_001067; Spectrum5_001260; Ester dwuetyloaminoetylowy kwasu dwufenylooctowego; BSPBio_000289; CBDivE_011564; CBDivE_014652; Diphenylacetyldiethylaminoethyl; KBioGR_001394; KBioSS_001796; 4-09-00-02497 (Beilstein Handbook Reference); DivK1c_000221; SCHEMBL248213; SPBio_001593; SPBio_002210; Adiphenine chloride (Salt/Mix); BPBio1_000319; CHEMBL353846; DTXSID0022561; CTK5C1933; KBio1_000221; KBio2_001796; KBio2_004364; KBio2_006932; KBio3_002048; NINDS_000221; ZINC1717372; BDBM50395519; STK178819; AKOS003656896; Diphenylacetate du diethylamino-ethanol; MCULE-6767246073; IDI1_000221; NCGC00016221-01; NCGC00016221-02; NCGC00016221-03; NCGC00016221-04; SBI-0051763.P002; AB00053636; ST50995221; AB00053636_13; AB00053636_14; Ethanol, 2-(diethylamino)-, 2,2-diphenylacetate; 2,2-diphenylacetic acid 2-(diethylamino)ethyl ester; Q4057596; BRD-K60907894-003-04-5; BRD-K60907894-003-14-4; Benzeneacetic acid, a-phenyl-, 2-(diethylamino)ethylester
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
IC50 = 112201.85 nM
|
[2] | ||
| Compound Name |
1-[7-(3-Chlorophenoxy)heptyl]azepane;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3747465; BDBM50134532
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
Ki ~ 150000 nM
|
[21] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 83 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Phentolamine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Dibasin; Fentolamin; Fentolamina; Phenotolamine; Phentalamine; Phentolaminum; Regitin; Regitine; Regitipe; Regityn; Rogitine; Phentolamine mesylate [USAN]; Phentolamine methanesulfonate; C 7337; C 7337 Ciba; Fentolamina [INN-Spanish]; Phentolamine (INN); Phentolamine [INN:BAN]; Phentolamine, methyl sulfonate; Phentolaminum [INN-Latin]; Vasomax (TN); 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline; 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline; 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
IC50 = 316227.77 nM
|
[2] | ||
| Compound Name |
imbutamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Imbutamine; 4-(1H-imidazol-5-yl)butan-1-amine; 40546-47-2; 1H-Imidazole-4-butanamine; imidazole-4-butanamine; 4-(4-aminobutyl)imidazole; CHEMBL90019; GTPL1249; SCHEMBL3885328; CTK8I6140; BDBM22907; DTXSID90542303; 4-(1H-imidazol-4-yl)butanamine; VJSUMPPMFYQOMP-UHFFFAOYSA-N; VUF-4701; 4-(1H-Imidazol-4-yl)-butylamine; BDBM50170164; AKOS032954093; AKOS006310860
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 794328.23 nM
|
[22] | ||
| Histamine H4 receptor |
Ki = 6.92E+16 nM
|
[24] | |||
| Compound Name |
AF353
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AF-353; AF 353
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 100000000 nM
|
[23] | ||
| Compound Name |
impentamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PDSP1_000940; PDSP2_000926
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 3.98E+12 nM
|
[22] | ||
| Histamine H4 receptor |
Ki = 2.69E+15 nM
|
[24] | |||
| Compound Name |
VUF-5297
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL13795; SCHEMBL7508989; BDBM50127605; AKOS006351626; (1S,2S)-2-(3H-Imidazol-4-yl)-cyclopropylamine
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 9.12E+14 nM
|
[24] | ||
| Compound Name |
VUF 5681
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78498; 4-[3-(1h-imidazol-4-yl)propyl]piperidine; 768358-61-8; VUF-5681; 4-[3-(1H-IMIDAZOL-4-YL)-PROPYL]-PIPERIDINE; SCHEMBL15139142; CHEBI:93084; ZINC13530263; BDBM50409817; AKOS006290761; NCGC00167742-01; KB-333611
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 1.62E+15 nM
|
[24] | ||
| Compound Name |
Immepip
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Immepip; 151070-83-6; 4-(1H-Imidazol-4-ylmethyl)piperidine; 4-(1H-imidazol-5-ylmethyl)piperidine; CHEBI:81390; Piperidine,4-(1H-imidazol-5-ylmethyl)-; 4-(1H-Imidazol-4-ylmethyl)-piperidine; 4-((1H-imidazol-4-yl)methyl)piperidine; Immepip, Dihydrobromide; 4-IMP; Tocris-0932; AC1MI02O; CHEMBL18661; ACMC-20n643; ZINC5777; SCHEMBL3338054; GTPL1251; BDBM22542; CTK4C6867; DTXSID10164703; FCH842654; BDBM50150945; AKOS006273473; AKOS015964158; 4-(3H-imidazol-4-ylmethyl)piperidine; NCGC00024883-01; NCGC00024883-02; CC-16184; KB-33506
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 4.57E+16 nM
|
[24] | ||
| Compound Name |
(+)-(S)-N,N-Dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090433; SCHEMBL4843907; BDBM50314261; N,N-dimethyl-2-[3-[(1S)-1-pyridin-2-ylethyl]-1-benzothiophen-2-yl]ethanamine
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
IC50 = 256000 nM
|
[18] | ||
| Compound Name |
(2S)-2-[[4-(3-Piperidin-1-ylpropoxy)phenyl]methylamino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238446; BDBM50001753
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 331131.12 nM
|
[25] | ||
| Compound Name |
4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)methyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594266; BDBM50304522
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 376600 nM
|
[26] | ||
| Compound Name |
2,4-Imidazolidinedione, 5,5-diphenyl-3-(3-(1-piperidinyl)propyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233067; 5,5-Diphenyl-3-(3-(1-piperidinyl)propyl)-2,4-imidazolidinedione; 3-(3-(1-Piperidyl)propyl)-5,5-diphenylhydantoin; 5,5-diphenyl-3-[3-(1-piperidinyl)propyl]-2,4-imidazolidinedione; SCHEMBL11713773; DTXSID90202253; 5,5-diphenyl-3-(3-piperidin-1-ylpropyl)imidazolidine-2,4-dione; BDBM50001755; ZINC33823602
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 489778.82 nM
|
[25] | ||
| Compound Name |
3-[5-Methyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]-1,2,4-triazol-3-yl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238445; BDBM50001752; 3-(5-methyl-4-(4-(3-(piperidin-1-yl)propoxy)phenyl)-4h-1,2,4-triazol-3-yl)pyridine
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 1412537.54 nM
|
[25] | ||
| Compound Name |
(5,7-Dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338937; SCHEMBL604650; (5,7-dichloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133011; (5,7-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 5000345.35 nM
|
[27] | ||
| Compound Name |
(4,5-Dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129436; SCHEMBL6130844; (4,5-dichloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133018; DB-102274; (4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 5000345.35 nM
|
[27] | ||
| Compound Name |
(7-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129488; SCHEMBL2167036; (7-methyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50132999; ZINC13526677; DB-102344; (7-methyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 6998419.96 nM
|
[27] | ||
| Compound Name |
(5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128613; SCHEMBL604107; (5-bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133005; ZINC13526656; AKOS017188762; (5-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 7998342.55 nM
|
[27] | ||
| Compound Name |
(7-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129540; SCHEMBL6130862; (7-amino-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133004; ZINC13526674; AKOS012418634; DB-102341; (7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 7998342.55 nM
|
[27] | ||
| Compound Name |
(4-Cyclobutylpiperazin-1-yl)-(6-cyclohexylspiro[2.5]octan-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127673; BDBM50496274
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
Ki > 10000000 nM
|
[28] | ||
| Compound Name |
Ethyl 1-[3-(4-sulfamoylphenoxy)propyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024379; BDBM50382855
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 10000000 nM
|
[8] | ||
| Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024387; BDBM50382860
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 10000000 nM
|
[8] | ||
| Compound Name |
Ethyl 1-[2-(4-sulfamoylphenoxy)ethyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024310; BDBM50382853
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 10000000 nM
|
[8] | ||
| Compound Name |
1-Cyclohexyl-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021977; BDBM50382883
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 10000000 nM
|
[8] | ||
| Compound Name |
1-Cyclohexyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024386; BDBM50382859
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 10000000 nM
|
[8] | ||
| Compound Name |
Ethyl 1-[4-(4-sulfamoylphenoxy)butyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024383; BDBM50382857
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 10000000 nM
|
[8] | ||
| Compound Name |
(5,7-Difluoro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129444; SCHEMBL604377; (5,7-difluoro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133019; (5,7-Difluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 13995873.23 nM
|
[27] | ||
| Compound Name |
(5-Fluoro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436381; (5-fluoro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; MLS001214246; SCHEMBL603452; HMS2871N19; BDBM50132996; STK298869; ZINC20028330; AKOS005428853; MCULE-6862698414; SMR000543901; (5-Fluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 14996848.36 nM
|
[27] | ||
| Compound Name |
(5-Amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340740; (5-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone; SCHEMBL6141960; (5-amino-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133001; ZINC13526669; AKOS012419079; DB-102308
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 14996848.36 nM
|
[27] | ||
| Compound Name |
(7-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338051; SCHEMBL605903; (7-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133016; (7-Chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 19010782.8 nM
|
[27] | ||
| Compound Name |
(5-Hydroxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128958; SCHEMBL6130834; (5-hydroxy-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133007; ZINC13526666; DB-102317; (5-hydroxy-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 23014418.17 nM
|
[27] | ||
| Compound Name |
(5,7-Dimethyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129026; SCHEMBL6130873; (5,7-dimethyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133008; DB-102307; (5,7-Dimethyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 30974192.99 nM
|
[27] | ||
| Compound Name |
(4-Bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128505; SCHEMBL6130876; (4-bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133009; (4-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 31988951.1 nM
|
[27] | ||
| Compound Name |
(5-Methyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128088; (5-methyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone; SCHEMBL601515; BDBM50133017; STK166449; ZINC19859265; AKOS005409247; MCULE-6140668924; (5-methyl-1H-indol-2-yl)(4-methylpiperazino)methanone; (5-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 46025657.36 nM
|
[27] | ||
| Compound Name |
(7-Bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128252; SCHEMBL602369; CTK1D2077; DTXSID50433460; BDBM50133015; (7-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone; (7-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone; Piperazine, 1-[(7-bromo-1H-indol-2-yl)carbonyl]-4-methyl-
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 61094202.49 nM
|
[27] | ||
| Compound Name |
Ethyl 1-[4-[4-(phenylcarbamoylsulfamoyl)phenoxy]butyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021980; BDBM50382838
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 100000000 nM
|
[8] | ||
| Compound Name |
1-Propan-2-yl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024384; BDBM50382832
Click to Show/Hide
|
||||
| Activity | Histamine H3 receptor |
IC50 > 100000000 nM
|
[8] | ||
| Compound Name |
6-(1H-Imidazol-5-yl)hexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554031; SCHEMBL9220957; VUF-4732; BDBM50407522
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.00E+12 nM
|
[7] | ||
| Histamine H2 receptor |
Ki = 5.01E+12 nM
|
[22] | |||
| Histamine H4 receptor |
Ki = 1.32E+15 nM
|
[24] | |||
| Compound Name |
1H-Imidazol-5-yl(piperidin-4-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345954; BDBM50474432
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 2.09E+12 nM
|
[24] | ||
| Compound Name |
4-(1H-Imidazol-5-yl)-1,2,3,6-tetrahydropyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150243; BDBM50474429; ZINC14985637
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 3.80E+12 nM
|
[24] | ||
| Compound Name |
2-Benzylthiazole-4-ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154695; 2-(2-benzyl-4-thiazolyl)ethanamine; SBB076746; AKOS005136294; 2-[2-benzyl-1,3-thiazol-4-yl]ethylamine
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 1.58E+13 nM
|
[7] | ||
| Compound Name |
8-(1H-Imidazol-5-yl)octan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90063; VUF-4733; BDBM50407520
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+13 nM
|
[7] | ||
| Histamine H2 receptor |
Ki = 3.16E+13 nM
|
[22] | |||
| Compound Name |
2-(2-Phenyl-thiazol-4-yl)-ethylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(2-phenyl-1,3-thiazol-4-yl)ethan-1-amine; 2-(2-Phenyl-4-thiazolyl)ethanamine; 2-(2-phenyl-1,3-thiazol-4-yl)ethylamine; 2-(2-phenyl-1,3-thiazol-4-yl)ethanamine; 2-Phenylthiazole-4-ethanamine; CHEMBL156131; SCHEMBL14736420; CTK7E7624; 4-Thiazoleethanamine, 2-phenyl-; ZINC6341451; 2-(2-Phenylthiazol-4-yl)ethanamine; 2-(2-Phenylthiazol-4-yl)ethylamine; 7350AE; SBB027411; AKOS000303356; MCULE-8500640412; NE17830; VS-0208; ST50484951; F1967-1945; Z1331054517
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.16E+13 nM
|
[7] | ||
| Compound Name |
9-Pyridin-2-ylnonan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154566; BDBM50422498; ZINC13531715
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.16E+13 nM
|
[7] | ||
| Compound Name |
2-(3-Chlorobenzyl)thiazole-4-ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153919; AKOS012225652
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.16E+13 nM
|
[7] | ||
| Compound Name |
1H-Imidazole-5-decanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94249; BDBM50407521; 10-(1H-imidazol-5-yl)decan-1-amine
Click to Show/Hide
|
||||
| Activity | Histamine H2 receptor |
Ki = 5.01E+13 nM
|
[22] | ||
| Histamine H1 receptor |
Ki = 2.00E+14 nM
|
[7] | |||
| Compound Name |
1H-Imidazole-5-nonanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345185; BDBM50422501; 9-(1H-imidazol-5-yl)nonan-1-amine
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 5.01E+13 nM
|
[7] | ||
| Compound Name |
10-Pyridin-2-yldecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154047; ZINC13531718
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 7.94E+13 nM
|
[7] | ||
| Compound Name |
2-[3-(Trifluoromethyl)phenyl]thiazole-4-ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157328; AKOS006168483
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 7.94E+13 nM
|
[7] | ||
| Compound Name |
2-[2-(3-Cyclohexyl-3-phenylpropyl)-1H-imidazol-5-yl]ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157264
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 1.00E+14 nM
|
[7] | ||
| Compound Name |
2-(1H-Imidazol-4-ylmethyl)piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150703; BDBM50474434; L009041
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 1.12E+14 nM
|
[24] | ||
| Compound Name |
2-(2,2-Diphenylethyl)-1H-imidazole-4-ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11584
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 1.26E+14 nM
|
[7] | ||
| Compound Name |
10-Pyridin-3-yldecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157842; BDBM50422506
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 1.26E+14 nM
|
[7] | ||
| Compound Name |
10-Pyridin-4-yldecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359122; BDBM50422493
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.00E+14 nM
|
[7] | ||
| Compound Name |
2-[2-(1H-Imidazol-5-yl)ethyl]piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150512; BDBM50474431; AKOS006313058
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 2.24E+14 nM
|
[24] | ||
| Compound Name |
5-(10-Pyrrolidin-1-yldecyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157217; BDBM50422503; ZINC13531708
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+14 nM
|
[7] | ||
| Compound Name |
5-(8-Pyrrolidin-1-yloctyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152126; BDBM50422494; ZINC13531705
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+14 nM
|
[7] | ||
| Compound Name |
12-Pyridin-4-yldodecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157273; BDBM50422500; ZINC13531733
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+14 nM
|
[7] | ||
| Compound Name |
12-(3-Pyridyl)-1-dodecanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152122; BDBM50422497
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+14 nM
|
[7] | ||
| Compound Name |
2-[2-[3-(Trifluoromethyl)phenyl]-1H-imidazol-5-yl]ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(3-trifluoromethylphenyl)histamine; CHEMBL24665; 2-[3-(Trifluoromethyl)phenyl]histamine; SCHEMBL3012997; BDBM50403672; 2-(3-(trifluormethyl)phenyl)-histamine; NCGC00165906-01; L000054; 2-(3-Trifluoromethylphenyl)-1H-imidazole-4-(ethanamine)
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+14 nM
|
[7] | ||
| Compound Name |
2-[3-Phenyl-3-(4-methylphenyl)propyl]-1H-imidazole-4-(ethanamine)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153994
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.16E+14 nM
|
[7] | ||
| Compound Name |
4-[1-(1H-Imidazol-4-yl)vinyl]piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152936; BDBM50474428; ZINC13530299
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 3.55E+14 nM
|
[24] | ||
| Compound Name |
2-(3,3-Diphenylpropyl)-4-(2-pyrrolizinoethyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11879; BDBM50409190
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.98E+14 nM
|
[7] | ||
| Compound Name |
11-(1H-Imidazol-5-yl)undecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158352; BDBM50422502; ZINC13531693
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.98E+14 nM
|
[7] | ||
| Compound Name |
2-[3-Phenyl-3-(4-bromophenyl)propyl]-1H-imidazole-4-(ethanamine)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346993
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.98E+14 nM
|
[7] | ||
| Compound Name |
4-(1H-Imdazol-4-yl)piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(1H-imidazol-5-yl)piperidine; 4-(1H-imidazol-4-yl)piperidine; 4-(1H-Imidazole-4(5)-yl) piperidine; 4-(4-imidazolyl)piperidine; Piperidine, 4-(1H-imidazol-4-yl)-; CHEMBL358028; 4-(1H-IMIDAZOL-5-YL)-PIPERIDINE; SCHEMBL3308039; SCHEMBL8515054; 4-(4-piperidyl)-1H-imidazole; 4-(4-piperidyl)1-H-imidazole; DTXSID40443316; 4-(4-piperidyl) 1-H-imidazole; 4-(4-piperidyl)-1-H-imidazole; KS-00000NQ9; ZINC2577862; BDBM50474422; MFCD02179572; AKOS006352052; AKOS022634729; AB62367; CS-W005814; FS-3355; GT-2035; MCULE-2144343716; NE25541; VP80155; AC-11983; AK-49020; BR-49020; AB0034619; FT-0687467; X8797; EN300-89815; S-7343; F2167-2439; METHYLTHIENO[3,2-B!THIOPHENE-2-CARBOXYLATE,97
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 4.57E+14 nM
|
[24] | ||
| Compound Name |
5-(12-Pyrrolidin-1-yldodecyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152221; BDBM50422499; ZINC13531711
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 5.01E+14 nM
|
[7] | ||
| Compound Name |
Piperidine, 4-(1H-imidazol-4-ylmethylene)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL356666; CTK0J7802; DTXSID80472625; BDBM50474425; L009047
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 5.75E+14 nM
|
[24] | ||
| Compound Name |
2-(4,4-Diphenylbutyl)-1H-imidazole-4-ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL274768
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 6.31E+14 nM
|
[7] | ||
| Compound Name |
2-(5,5-Diphenylpentyl)-1H-imidazole-4-ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL274767; BDBM50409187
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 7.94E+14 nM
|
[7] | ||
| Compound Name |
2-(12-Aminododecyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
12-pyridin-2-yldodecan-1-amine; CHEMBL157843; SCHEMBL13891482
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 1.00E+15 nM
|
[7] | ||
| Compound Name |
12-(1H-Imidazol-5-yl)dodecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155188; BDBM50422495; ZINC13531696
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 1.00E+15 nM
|
[7] | ||
| Compound Name |
3-(1H-Imidazol-5-ylmethyl)piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151467; SCHEMBL15944212; CTK9A2066; BDBM181143; US9138393, Immepip dihydrobromide; US9144538, Immepip dihydrobromide; piperidine,3-(1h-imidazol-4-ylmethyl)-; 3-((1H-Imidazol-4-yl)methyl)piperidine; L009043
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 1.62E+15 nM
|
[24] | ||
| Compound Name |
2-[3-(1H-Imidazol-5-yl)propyl]piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152948; BDBM50474430
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 1.74E+15 nM
|
[24] | ||
| Compound Name |
13-(1H-Imidazol-5-yl)tridecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156071; BDBM50422496; ZINC13531699
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 2.51E+15 nM
|
[7] | ||
| Compound Name |
3-[3-(1H-Imidazol-5-yl)propyl]piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154529; BDBM50150943
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 2.57E+15 nM
|
[24] | ||
| Compound Name |
4-[2-(1H-Imidazol-4-yl)ethyl]piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150701; 4-[2-(1H-imidazol-5-yl)ethyl]piperidine; Piperidine, 4-[2-(1H-imidazol-5-yl)ethyl]-; SCHEMBL6353897; CTK8I0996; VUF-4929; BDBM50409216; AKOS006312757
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 2.69E+15 nM
|
[24] | ||
| Compound Name |
3-[2-(1H-Imidazol-4-yl)ethyl]piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153207; BDBM50150944; AKOS006312758
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 3.09E+15 nM
|
[24] | ||
| Compound Name |
14-(1H-Imidazol-5-yl)tetradecan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155314; BDBM50422504; ZINC13531702
Click to Show/Hide
|
||||
| Activity | Histamine H1 receptor |
Ki = 3.98E+15 nM
|
[7] | ||
| Compound Name |
(S)-4-(Pyrrolidin-3-ylmethyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153051; BDBM50474424
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 7.08E+15 nM
|
[24] | ||
| Compound Name |
[2-(1H-Imidazol-5-yl)cyclopropyl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153284; SCHEMBL6136828; BDBM50474423; AKOS006350308; L021278
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 8.91E+15 nM
|
[24] | ||
| Compound Name |
5-(Pyrrolidin-3-ylmethyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153061; SCHEMBL8515210; BDBM50474427
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 1.95E+16 nM
|
[24] | ||
| Compound Name |
(R)-4-(Pyrrolidin-3-ylmethyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440730; BDBM50474433
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 2.69E+16 nM
|
[24] | ||
| Compound Name |
1H-Imidazole-4-propanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Imidazolyl-4-propylamine; 3-(1H-imidazol-5-yl)propan-1-amine; 1H-Imidazole-4-propylamine; Homohistamine; 3-(1h-imidazol-4-yl)propan-1-amine; 3-(1H-IMIDAZOL-4-YL)PROPYLAMINE; EINECS 254-968-6; 4-(3-aminopropyl) imidazole; CHEMBL91353; 3-(5-imidazolyl)-propylamine; 3-(imidazol-4-yl)propylamine; SCHEMBL1073990; SCHEMBL8609440; 3-(imidazol-4-yl)-propylamine; 3-(imidazole-4-yl)-propylamine; BDBM22906; CTK1D7617; CTK7E7803; DTXSID20193569; 4-(3-aminopropyl)-1H-imidazole; 3-(1H-imidazol-4-yl)propanamine; 1H-IMIDAZOLE-5-PROPANAMINE; 3-(1h-imidazol-4-yl)propyl amine; VUF-8326; ZINC5116857; 3-(1H-Imidazol-4-yl)-propylamine; BDBM50474435; AKOS006240507; AKOS022633180; AB10031; BB 0261525
Click to Show/Hide
|
||||
| Activity | Histamine H4 receptor |
Ki = 2.88E+16 nM
|
[24] | ||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity | Histamine H4 receptor |
Ki = 2.63E+14 nM
|
[24] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Histamine H4 receptor agonists. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7191-9. | ||||
| REF 2 | Shape-based reprofiling of FDA-approved drugs for the H1 histamine receptor. J Med Chem. 2012 Aug 23;55(16):7054-60. | ||||
| REF 3 | Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H 3 R ligands. Eur J Med Chem. 2018 May 25;152:223-234. | ||||
| REF 4 | Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2035-7. | ||||
| REF 5 | Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4267-74. | ||||
| REF 6 | Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3055-8. | ||||
| REF 7 | Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. J Med Chem. 2003 Dec 18;46(26):5812-24. | ||||
| REF 8 | Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies. Eur J Med Chem. 2012 Jun;52:1-13. | ||||
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