Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T12808 Target Info
Target Name Protein kinase C alpha (PRKCA)
Synonyms Protein kinase C alpha type; PRKACA; PKCalpha; PKCA; PKC-alpha; PKC-A
Target Type Successful Target
Gene Name PRKCA
Biochemical Class Kinase
UniProt ID
P17252
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-142-3p miRNA Info
miRNA Mature AC
MIMAT0000434
Sequence uguaguguuuccuacuuuaugga
miRNA Species Homo sapiens
Regulation Mechanism Cultures transfected with miR-142-3p mimic displayed reduced PKCA at the level of mRNA and protein. [2]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [1]
2 Western Blot [2]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter G2 (ABCG2) Target Info
ABCG2_HUMAN
High mobility group protein B1 (HMGB1) Target Info
HMGB1_HUMAN
miRNA Mature ID hsa-miR-150-5p miRNA Info
miRNA Mature AC
MIMAT0000451
Sequence ucucccaacccuuguaccagug
miRNA Species Homo sapiens
Regulation Mechanism Luciferase activity was significantly inhibited in cells transfected with wt-PRKCA-3'UTR compared with that in cells transfected with mut-PRKCA-3'UTR. [3]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
Beta-arrestin-2 (ARRB2) Target Info
ARRB2_HUMAN
miRNA Mature ID hsa-miR-203a-3p miRNA Info
miRNA Mature AC
MIMAT0000264
Sequence gugaaauguuuaggaccacuag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [4]
Representative Target(s) Regulated by This miRNA Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
Apoptosis regulator Bcl-W (BCL-W) Target Info
B2CL2_HUMAN
References  Top
REF 1 miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways. Cell Death Dis. 2016 Sep 22;7(9):e2371.
REF 2 MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts. Sci Rep. 2016 Apr 26;6:24980.
REF 3 Specific miRNA and its target in neutrophils after traumatic injury. Acta Biochim Biophys Sin (Shanghai). 2015 Sep;47(9):749-54.
REF 4 miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKC. PLoS One. 2013 Sep 10;8(9):e73985.

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