Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T34296 Target Info
Target Name Matrix metalloproteinase-13 (MMP-13)
Synonyms Matrix metalloproteinase 13; Collagenase-3; Collagenase 3
Target Type Clinical trial Target
Gene Name MMP13
Biochemical Class Peptidase
UniProt ID
P45452
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-143-3p miRNA Info
miRNA Mature AC
MIMAT0000435
Sequence ugagaugaagcacuguagcuc
miRNA Species Homo sapiens
Regulation Mechanism MMP13 is a direct target gene of miR-143 in prostate cancer. [2]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [1]
2 Western Blot; Microarray [2]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Connective tissue growth factor (CTGF) Target Info
CTGF_HUMAN
miRNA Mature ID hsa-miR-27b-3p miRNA Info
miRNA Mature AC
MIMAT0000419
Sequence uucacaguggcuaaguucugc
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-27b-3p by mature miRNA precursor transfection resulted in the decreased protein level of target MMP13. [4]
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay; qRT-PCR; Western Blot [3]
2 ELISA; Luciferase Reporter Assay; qRT-PCR; Western Blot [4]
Representative Target(s) Regulated by This miRNA Adenosine A2b receptor (ADORA2B) Target Info
AA2BR_HUMAN
Albendazole monooxygenase (CYP3A4) Target Info
CP3A4_HUMAN
miRNA Mature ID hsa-miR-100-5p miRNA Info
miRNA Mature AC
MIMAT0000098
Sequence aacccguagauccgaacuugug
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Western Blot [4]
Representative Target(s) Regulated by This miRNA ATM serine/threonine kinase (ATM) Target Info
ATM_HUMAN
Bone morphogenetic protein receptor (BMPR2) Target Info
BMPR2_HUMAN
miRNA Mature ID hsa-miR-140-5p miRNA Info
miRNA Mature AC
MIMAT0000431
Sequence cagugguuuuacccuaugguag
miRNA Species Homo sapiens
Regulation Mechanism MMP-13 is a indirect target of miR-140. [5]
Evidence Score (E-score) 1 +
1 qRT-PCR [5]
Representative Target(s) Regulated by This miRNA Adenosine deaminase (ADA) Target Info
ADA_HUMAN
Aspartyl aminopeptidase (DNPEP) Target Info
DNPEP_HUMAN
miRNA Mature ID hsa-miR-27a-3p miRNA Info
miRNA Mature AC
MIMAT0000084
Sequence uucacaguggcuaaguuccgc
miRNA Species Homo sapiens
Regulation Mechanism miR-27a down-regulates of MMP-13. [5]
Evidence Score (E-score) 1 +
1 qRT-PCR [5]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter A1 (ABCA1) Target Info
ABCA1_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-127-3p miRNA Info
miRNA Mature AC
MIMAT0000446
Sequence ucggauccgucugagcuuggcu
miRNA Species Homo sapiens
Regulation Mechanism miR-127 decreases MMP13 3'UTR reporter activity and protein expression and MMP13 is a direct target gene of miR-127. [6]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [6]
Representative Target(s) Regulated by This miRNA Matrix metalloproteinase-13 (MMP-13) Target Info
MMP13_HUMAN
O-6-methylguanine-DNA-alkyltransferase (MGMT) Target Info
MGMT_HUMAN
References  Top
REF 1 MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer. Mol Med Rep. 2013 Aug;8(2):626-30.
REF 2 MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther. 2011 Jun;19(6):1123-30.
REF 3 MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum. 2010 May;62(5):1361-71.
REF 4 Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82.
REF 5 Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord. 2009 Nov 30;10:148.
REF 6 A feedback inhibition between miRNA-127 and TGF/c-Jun cascade in HCC cell migration via MMP13. PLoS One. 2013 Jun 7;8(6):e65256.

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