Target Regulator(s) Information (MicroRNA)

Content Navigation (  All   None )                                      
Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T60254 Target Info
Target Name Voltage-gated potassium channel Kv10.1 (KCNH1)
Synonyms hEAG1; h-eag; Voltage-gated potassium channel subunit Kv10.1; Potassium voltage-gated channel subfamily H member 1; EAG1; EAG channel 1; EAG
Target Type Literature-reported Target
Gene Name KCNH1
Biochemical Class Voltage-gated ion channel
UniProt ID
O95259
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-34a-5p miRNA Info
miRNA Mature AC
MIMAT0000255
Sequence uggcagugucuuagcugguugu
miRNA Species Homo sapiens
Regulation Mechanism Endogenous Eag1 protein level in miR-34a group cells was significantly decreased. [1]
Evidence Score (E-score) 1 +
1 Western Blot [1]
Representative Target(s) Regulated by This miRNA Amphiregulin (AREG) Target Info
AREG_HUMAN
Androgen receptor (AR) Target Info
ANDR_HUMAN
miRNA Mature ID hsa-miR-296-3p miRNA Info
miRNA Mature AC
MIMAT0004679
Sequence gaggguuggguggaggcucucc
miRNA Species Homo sapiens
Regulation Mechanism EAG1 as a direct target of miR-296-3p in GBM cells. [2]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [2]
Representative Target(s) Regulated by This miRNA C-X3-C chemokine receptor 1 (CX3CR1) Target Info
CX3C1_HUMAN
Intercellular adhesion molecule ICAM-1 (ICAM1) Target Info
ICAM1_HUMAN
References  Top
REF 1 MicroRNA-34a inhibits human osteosarcoma proliferation by downregulating ether go-go 1 expression. Int J Med Sci. 2013;10(6):676-82.
REF 2 MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether- go-go (EAG1). Eur J Cancer. 2013 Feb;49(3):710-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.