Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | N-((S)-4-cyclohexyl-1-((S)-1-(5-fluoroindolin-1-yl)-4-morpholinobutan-2-ylamino)-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| Cathepsin K --- MEP | 3-Bromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide | Drug Info |
| CCKBR --- CCKAR | Boc-Tyr(So3-)-Nle-Gly-Trp-psi(CH2NH)-Nle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(naphthalene-1-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid.NH4OH; hydrate | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[(S)-2-(3,3-diphenyl-propionylamino)-3-1H-indol-3-yl-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2,4-dimethoxy-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 2-[3-(4-Chloro-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-5-(3-chloro-phenyl)-3-[3-(3-chloro-phenyl)-ureido]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 5-(R)-Oxo-5-(4-phenylcarbamoyl-piperidin-1-yl)-4-(3-m-tolyl-ureido)-pentanoic acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | N-[(Isopropyl-phenyl-carbamoyl)-methyl]-N-phenyl-2-(3-phenyl-ureido)-acetamide | Drug Info |
| CCKBR --- CCKAR | {[2-(Adamantan-2-yloxycarbonylamino)-3-(4-bromo-phenyl)-2-methyl-propionyl]-phenethyl-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | Boc-Phe(CH2-SO3Na)-gNle-mCIy-Trp-(N-Me)Nle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-(2-{[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-methyl-amino}-hexanoylamino)-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CD135 --- Ckit | N3-(3-(1-methylpiperidin-4-yl)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine | Drug Info |
| CD221 --- JNK1 | 2-fluoro-6-(2-(5-methoxy-1-(3-morpholinopropanoyl)indolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- CDK2 | SID124349855 | Drug Info |
| CDK1 --- CDK2 | [4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-phenyl]-acetonitrile | Drug Info |
| CDK1 --- GSK3 | (E/Z) 8-[3-(3-Hydroxy-4-methoxyphenyl) pyrrolo[2,3-b]pyrrolizin-8(1H)-one]oxime | Drug Info |
| CDK1 --- GSK3 | 7-(3-Chloro-propyl)-6-(4-methoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- GSK3 | N-Benzyl-8-isopopyl-9-oxo-8,9-dihydro[1,3]thiazolo[5,4-f]quinazoline-2-carboxamidine | Drug Info |
| CDK1 --- VEGFR | 6-Bromo-13-thia-2,4,8,12,19-pentaaza-tricyclo[12.3.1.1*3,7*]nonadeca-1(17),3(19),4,6,14(18),15-hexaene 13,13-dioxide | Drug Info |
| CDK2 --- AKT | (R)-N-(azetidin-3-yl(3,4-dichlorophenyl)methyl)isoquinoline-6-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(2-Chlorophenylamino)-5-methylpyrimidin-4-yl}-N-{1-phenyl-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- AuroraA | 1-Phenyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | 4-[(2-Oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]-N-thiazol-2-yl-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid cyclohexyl-amide | Drug Info |
| CDK2 --- CDK1 | 2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)ethanol | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(5-fluoro-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic Acid(trans-4-Amino-cyclohexyl)-amide | Drug Info |
| CDK2 --- CDK1 | 2-((2-(3-hydroxypropylamino)-9-isopropyl-9H-purin-6-ylamino)methyl)phenol | Drug Info |
| CDK2 --- CDK4 | 3,5-Dimethyl-4-[2-(3-nitro-phenylamino)-pyrimidin-4-yl]-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | (3-Bromo-5-trifluoromethyl-phenyl)-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- CDK4 | (4Z)-6-Fluoro-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-benzonitrile | Drug Info |
| CDK2 --- CSrc | 4-(thiazol-2-yl)-N-m-tolylpyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | N-{4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-1,3-thiazol-2-yl}-acetamide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-phenylfuran-3-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-(4-hydroxy-tetrahydro-pyran-4-ylethynyl)-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | N-[3-(4-Methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-isobutyramide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-((6-(3-fluorophenyl)pyridin-3-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | {3-[3-Ethyl-4-oxo-1-(2,4,6-trichloro-phenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylmethyl]-phenyl}-acetic acid ethyl ester | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-N6-(biphenyl-4-ylmethyl)-9-methyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | (3,5-Dimethoxy-phenyl)-[4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CAII --- CAI | 6-(Heptadecafluorooctane-1-sulfonylamino)-benzothiazole-2-sulfonic acid amide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(4-Dimethylamino-piperidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 2-ethyl-N-(4-sulfamoylbenzyl)butanamide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-pyridinium; perchlorate | Drug Info |
| COX2 --- 5LOX | 6-(7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-imidazo[2,1-b]thiazole | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
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