Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- AKT | (S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)-3-(4-fluorophenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AKT | (S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-cyanobenzamide | Drug Info |
| CDK2 --- AuroraA | 8-{[4-(Dimethylamino)phenyl]amino}-N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | {4-[(7-Oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-phenyl}-methanesulfonamide | Drug Info |
| CDK2 --- CDK1 | N*2*-(3-Bromo-phenyl)-6-cyclohexylmethoxy-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK1 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-2-methoxy-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-((5-(oxazol-5-yl)-2-oxoindolin-3-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | [4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-phenyl]-acetonitrile | Drug Info |
| CDK2 --- CDK1 | (Z)-4-((5-(3-methylbutanoyl)-2-oxoindolin-3-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 4-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)benzonitrile | Drug Info |
| CDK2 --- CDK4 | 8-Cyclopentyl-5-methyl-7-oxo-2-(4-piperazin-1-yl-phenylamino)-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester | Drug Info |
| CDK2 --- CDK4 | (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(6-methyl-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CDK2 --- CDK4 | 1-{4-[4-(2-Bromo-phenylamino)-pyrimidin-2-ylamino]-phenoxy}-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-(6-furan-2-yl-2-trifluoromethyl-quinazolin-4-yl)-amine | Drug Info |
| CDK2 --- Cyclin E | 2-(5-((2-benzamidothiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide | Drug Info |
| CDK2 --- Cyclin E | 4-tert-Butylamino-2-trifluoromethyl-quinazolin-6-ol | Drug Info |
| CDK2 --- Cyclin E | N-[3-(4-Methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-2-thiomorpholin-4-yl-acetamide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(4-methylthiophen-2-yl)benzyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 4-(1-Hydroxy-2-{[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-methyl-amino}-ethyl)-benzene-1,2-diol | Drug Info |
| CDK2 --- Cyclin E | N-(3-((2-acetamidothiazol-4-yl)methyl)-5-(cyanomethylthio)-4H-1,2,4-triazol-4-yl)-4-chlorobenzamide | Drug Info |
| CDK2 --- GSK3 | N-(6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 1-[(2-Iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,6-diisopropyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| CDK4 --- Cyclin E | N-[3-(5-chlorothien-3-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-2,2-dimethylhydrazinecarboxamide | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-sulfamoyl-benzothiazol-6-yloxycarbonylmethyl)-amino]-acetic acid | Drug Info |
| Ckit --- BRaf | 5-(pyridin-4-ylmethylamino)-N-(2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiazole-4-carboxamide | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-1-{[4-(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenesulfamoyl)-phenylcarbamoyl]-methyl}-4-phenyl-pyridinium; perchlorate | Drug Info |
| Cmet --- CD135 | 2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide | Drug Info |
| CAII --- CAI | 3-Hydroxy-2-(4-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| COX2 --- 5LOX | Tebufelone | Drug Info |
| CAII --- CAI | N-(2-Fluoro-4-sulfamoyl-phenyl)-2-(N-methyl-guanidino)-acetamide | Drug Info |
| COX2 --- 5LOX | 5-((Z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-amino-4-thiazolidinone | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid (2-bromo-4-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- AuroraA | K00244 | Drug Info |
| CAII --- CAI | 6,6,7,7,7-Pentafluoro-heptanoic acid [3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-amide | Drug Info |
| CSrc --- CABL | (E)-N-(4-Methyl-3-(2-(6-(pyridine-2-yl-amino)-9H-purin-9-yl)vinyl)phenyl)-3-(trifluoromethyl)-benzamide | Drug Info |
| CAII --- CAI | 6-[2-(2-Sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| CSrc --- CABL | N-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | Ethyl1-(3-(2-(2,4-dioxopentan-3-ylidene)hydrazinyl)phenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazole-4-carboxylate | Drug Info |
| CSrc --- CABL | (3-Bromo-phenyl)-[6-methylsulfanyl-1-(2-phenyl-propyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine | Drug Info |
| CAII --- CAI | N-[4-(trifluoromethyl)phenyl]sulfamide | Drug Info |
| CSrc --- CABL | 4-(2-Chloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | {[(2-Iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- CD135 | K00088 | Drug Info |
| CAII --- CAI | 4-(3-Pentafluorophenyl-ureidomethyl)-benzenesulfonamide | Drug Info |
| CSrc --- FGFR1 | 1-{2-Amino-6-[3-(2-diethylamino-ethoxy)-2,6-dimethyl-phenyl]-pyrido[2,3-d]pyrimidin-7-yl}-3-tert-butyl-urea | Drug Info |
| CAII --- CAI | Zinc; {{2-[Carboxymethyl-(2-{carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | {{2-[Carboxymethyl-(2-{carboxymethyl-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR --- HER2 | SID124350109 | Drug Info |
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