Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CSrc --- TEK | (1R,2R)-2-Phenyl-cyclopropanecarboxylic acid (4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-ylmethyl}-2-methoxy-phenyl)-amide | Drug Info |
| CAII --- CAI | ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 1-[(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,6-diisopropyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| EGFR --- HER2 | SID124349869 | Drug Info |
| CAII --- CAI | 3-(4-Hydroxy-phenyl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| EGFR --- Src | methyl 4-[2-(2-{3-[2-(4-methyloxycarbonylbenzylcarbamoyl)ethyl]-1H-2-indolyldisulfanyl}-1H-3-indolyl)ethylcarboxamidomethyl]benzoate | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (2-chloro-4-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- CSrc | 2-(3-carbamoyl-1-methyl-1H-2-indolyldisulfanyl)-1-methyl-1H-3-indolecarboxamide0.5 H2O | Drug Info |
| CAII --- CAI | [2-(4-Chloro-3-sulfamoyl-benzoylamino)-acetylamino]-acetic acid | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidin-5-yl)-N-(2-morpholinoethyl)acrylamide | Drug Info |
| CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-5-(4-diethylamino)-2-pentynamide | Drug Info |
| CAII --- CAI | 3-(3,4-Dihydroxy-phenyl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Chloro-4-fluorobenzylamino)-7-methoxyquinazolin-6-yloxy)-hydroxyheptanamide | Drug Info |
| CAII --- CAI | {2-[3-(4-Sulfamoyl-phenyl)-thioureido]-acetylamino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((6-methyl-1,4-diazepan-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| CAII --- CAI | 5-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| EGFR3 --- HER2 | [3-Chloro-4-(pyridin-2-ylmethoxy)-phenyl]-[5-(tetrahydro-pyran-4-yloxy)-quinazolin-4-yl]-amine | Drug Info |
| CAII --- CAI | [(2-{2-[2-(Bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethyl)-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-acetic acid | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid trans-4-aminocyclohexyl ester | Drug Info |
| CAII --- CAI | 5-[(Z)-7-Chloro-2-oxo-2H-chromen-4-ylmethylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| EGFR3 --- HER2 | 4-(Bis(2-chloroethyl)amino)-N-(4-methoxyphenyl)benzamide | Drug Info |
| CAII --- CAI | (S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-ethoxy)-ethoxy]-ethyl}-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | {[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-carboxymethyl-amino}-acetic acid | Drug Info |
| CAII --- CAI | 6-(5-Chloro-2,4-disulfamoyl-phenylcarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (4-sulfamoyl-phenyl)-amide | Drug Info |
| CAII --- CAI | 6-(2-Iodo-4-sulfamoyl-phenylcarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| CAII --- CAI | N,N-dialkylthio-carbonylsulfenylamino derivative | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| CAII --- CAIX | 4-amino-3,5-diiodobenzenesulfonamide | Drug Info |
| CAIX --- CAXII | 2-mercaptopyridine 1-oxide | Drug Info |
| CALM2 --- Cathepsin B | 1-(Toluene-4-sulfonyl)-piperidine-2-carboxylic acid (1-benzyl-2-oxo-ethyl)-amide | Drug Info |
| CALM2 --- Cathepsin B | (2R,4R)-4-Cyano-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid ((S)-1-benzyl-2-oxo-ethyl)-amide | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-(2(R,S)-3,4-dioxo-4-(phenethylamino)-1-phenylbutan-2-yl)-1-(4-methoxyphenyl-sulfonylpyrrolidine-2-carboxamide | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl(S)-1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-2-((S)-1-(4-bromophenyl)-2,2,2-trifluoroethylamino)-N-(1-cyanocyclopropyl)-3-(methylsulfinyl)propanamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-methyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopentan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | 3-Phenyl-propionic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-4-oxo-azetidin-2-yl ester | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(pyridine-3-sulfonylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | N-[1-((S)-(S)-4-Benzoyl-6-(S)-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-3-methyl-butyl]-4-dimethylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | 6-(4-chlorobenzyl)-7-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (R,S)-4-methyl-2-[4'-(2-piperazin-1-yl-thiazol-4-yl)-biphenyl-3-yl]-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | 6-[4-(4-Acetyl-piperazin-1-yl)-phenoxymethyl]-7-[2-(4,4-difluoro-cyclohexyl)-ethyl]-7Hpyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | 2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-5-carboxylic acid ((S)-1-benzyl-2-pyrrolidin-1-yl-ethyl)-amide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-methanesulfonylaminocarbonyl-phenyl)-ureido]-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | [3-(4-Chloro-benzoylamino)-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-9-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-fluoro-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
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