Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- CSrc | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile | Drug Info |
| CAII --- CAI | 2-isopropyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| EGFR3 --- HER2 | 2-(2-(5-Chloro-2-hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | (S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-3-phenyl-propionic acid | Drug Info |
| EGFR3 --- HER2 | 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-isopropyl oxime | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-((S)-indan-1-yloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| CAII --- CAI | 3-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-(2-dimethylamino-ethoxy)-ethyl ester | Drug Info |
| EGFR3 --- HER2 | 3-(2-(1,2-oxazepan-2-yl)ethoxy)-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | [{2-[[(2-Chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| EGFR3 --- HER2 | 4-(3-Chloro-4-fluoro-phenylamino)-5-[1-[3-methyl-5-(4-methyl-piperazine-1-carbonyl)-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one | Drug Info |
| CAII --- CAI | (2S,3R)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-3-hydroxy-butyric acid | Drug Info |
| EGFR3 --- HER2 | 4-(2-isopropylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[4-(4-sulfamoyl-phenylsulfamoyl)-phenyl]-acetamide | Drug Info |
| EGFR3 --- HER2 | 5-[4-(3-Ethynyl-phenylamino)-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-(5Z)-ylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CAII --- CAI | 6-[2-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| CAII --- CAI | {[(4-Sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | {(2-{2-[2-(Bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethyl)-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(4-sulfamoyl-phenylamino)-pyrimidin-2-yl]-benzamide | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CAII --- CAI | 4-Chloro-6-(3-pentafluorophenyl-ureido)-benzene-1,3-disulfonic acid diamide | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (2-bromo-4-sulfamoyl-phenyl)-amide | Drug Info |
| CAII --- CAIX | Sulfamic acid 16-sulfamoyloxy-hexadecyl ester | Drug Info |
| CAIX --- CAXII | 4-(allyloxy)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(2-Hydroxy-2-phenyl-ethylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | (R)-1-(4-nitrophenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide | Drug Info |
| CALM2 --- Cathepsin B | 2-Diphenylacetylamino-4-methyl-pentanoic acid {1-benzyl-2-oxo-2-[(pyridin-2-ylmethyl)-carbamoyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-3,3-dimethyl-1-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)butan-2-yl(S)-1,2-dioxo-1-(2-oxooxazolidin-3-ylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((R)-2-(benzyloxy)-1-cyanoethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((S)-3-Benzyloxy-2-oxo-1-phenethyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 2,2-dimethyl-3-phenylpropyl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-(cyanomethyl)-4-methyl-2-((S)-2,2,2-trifluoro-1-(4-phenoxyphenyl)ethylamino)pentanamide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-3-methoxy-benzamide | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-2-(2-(4-chlorophenoxy)-2-methylpropanamido)-4-methylpentanamide | Drug Info |
| Cathepsin K --- MEP | 2-(cyclopentylmethyl)-N-(3-methyl-1-(4-(trifluoromethoxy)phenylamino)butan-2-yl)-4-morpholino-4-oxobutanamide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(4-fluorophenylamino)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-chloro-phenyl)-thioureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (R)-4,8-Dihydroxy-quinoline-2-carboxylic acid [1-dipentylcarbamoyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-naphthalen-2-yl-ureido)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-Isopropyl-2-[(3R,5S,7R)-2-oxo-7-phenyl-5-o-tolyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-((S)-3-1H-indol-3-yl-2-phenylacetylamino-propionylamino)-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (S)-3-[(S)-2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-((E)-3-pyridin-3-yl-acryloylamino)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | CHEMBL2372623 | Drug Info |
| CCKBR --- CCKAR | (R)-4-Dipentylcarbamoyl-4-[3-(3-methoxy-phenyl)-ureido]-butyric acid | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[(S)-2-(2,2-dimethyl-propionylamino)-3-1H-indol-3-yl-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-4-trifluoromethyl-benzamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-hydroxy-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CD135 --- Ckit | N3-(2-methoxy-5-morpholinophenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-(3-(dimethylamino)propanoyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
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