Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | 1-(3-(2-aminopyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidin-3-ol | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid amide | Drug Info |
| CDK2 --- CDK1 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-benzoic acid | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-isopropylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | N-[(E)-amino(imino)methyl]-4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 6-Acetyl-2-{5-[bis-(2-methoxy-ethyl)-amino]-pyridin-2-ylamino}-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- CDK4 | 1-[4-(5-Bromo-4-phenylamino-pyrimidin-2-ylamino)-phenoxy]-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- CDK4 | (4Z)-{[(5-Furan-3-yl-4-hydroxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | 6-Bromo-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- Cyclin E | (2-Chloro-9-methyl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-N6-((4'-chlorobiphenyl-4-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-[6-(4-methoxy-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | (R)-2-(6-(Biphenyl-4-ylmethylamino)-9-propyl-9H-purin-2-ylamino)butan-1-ol | Drug Info |
| CDK2 --- Cyclin E | N6-((6-(1H-pyrazol-1-yl)pyridin-3-yl)methyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-Aminocyclohexyl)-9-cyclopentyl-N6-(biphenyl-4-ylmethyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | 5-Hydroxy-3-(4-methoxy-phenyl)-2H-indeno[1,2-c]pyrazol-4-one | Drug Info |
| CDK2 --- GSK3 | N-(6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 5-chloro-2-hydroxybenzoic acid | Drug Info |
| CDK4 --- Cyclin E | 1-[3-(2,5-Dimethyl-thiophen-3-yl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-(4-methyl-piperazin-1-yl)-urea | Drug Info |
| CAII --- CAI | sodium 4-(dimethylamino)benzoate | Drug Info |
| Ckit --- BRaf | 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-benzylurea | Drug Info |
| CAII --- CAI | 4-(2-(pyridin-4-ylmethyleneamino)ethyl)benzenesulfonamide | Drug Info |
| COX --- PDE | kuraridin | Drug Info |
| CAII --- CAI | 4-(2-{[({[(3,4-dichlorophenyl)amino]carbonyl}amino)carbonothioyl]amino}ethyl)benzenesulfonamide | Drug Info |
| COX2 --- 5LOX | 1-(3,4-dichlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 3-(Nonafluorobutane-1-sulfonylamino)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| COX2 --- 5LOX | 3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-1-(4-fluorophenyl)-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-acetamide | Drug Info |
| CSrc --- CABL | N-(3-fluorobenzyl)-1-(2-phenylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-Amino-N-{2-[4-(2-hydroxy-ethyl)-benzenesulfonylamino]-2-oxo-ethyl}-acetamide | Drug Info |
| CSrc --- CABL | (S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-carboxy-butyrylamino}-4-carboxy-butyrylamino)-3-methyl-pentanoylamino]-pentanedioic acid | Drug Info |
| CAII --- CAI | N-1,3,4-thiadiazol-2-ylsulfamide | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(4-methylpiperazin-1-yl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 4-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-3-fluoro-benzenesulfonamide | Drug Info |
| CSrc --- CABL | N-(3-Chlorophenyl)-1-(2-chloro-2-phenylethyl)-6-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 5,10-dihydroindeno[1,2-b]indole-2,3-diol | Drug Info |
| CSrc --- CABL | N-(4-fluorobenzyl)-6-(methylthio)-1-(2-phenylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | sodium 4-(N,N-dichlorosulfamoyl)benzoate | Drug Info |
| CSrc --- CD221 | N'-[4-(2,5-Dimethyl-1H-pyrrol-1-yl)benzoyl]-2-(1H-indol-3-yl)-2-oxoacetohydrazide | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CSrc --- TEK | (1R,2R)-2-Phenyl-cyclopropanecarboxylic acid (4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-ylmethyl}-2-methoxy-phenyl)-amide | Drug Info |
| CAII --- CAI | ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 1-[(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,6-diisopropyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| EGFR --- HER2 | SID124349869 | Drug Info |
| CAII --- CAI | 3-(4-Hydroxy-phenyl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| EGFR --- Src | methyl 4-[2-(2-{3-[2-(4-methyloxycarbonylbenzylcarbamoyl)ethyl]-1H-2-indolyldisulfanyl}-1H-3-indolyl)ethylcarboxamidomethyl]benzoate | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (2-chloro-4-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- CSrc | 2-(3-carbamoyl-1-methyl-1H-2-indolyldisulfanyl)-1-methyl-1H-3-indolecarboxamide0.5 H2O | Drug Info |
| CAII --- CAI | [2-(4-Chloro-3-sulfamoyl-benzoylamino)-acetylamino]-acetic acid | Drug Info |
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