Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(2-hydroxyethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid amide | Drug Info |
| CDK1 --- CDK4 | (5-Piperazin-1-yl-pyridin-2-yl)-[4-(3-trifluoromethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CDK1 --- GSK3 | (E)-3-(6-Oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-benzo[2,3]azepino[4,5-b]indol-2-yl)-acrylic acid methyl ester | Drug Info |
| CDK1 --- GSK3 | 7-Butyl-6-(4-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | N-(3-chlorophenyl)-6-(5-{[3-(piperidin-1-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one | Drug Info |
| CDK2 --- AuroraA | 1-Cyclohexyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N,1-dimethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CD221 | 1-(4-(4-(5-chloro-4-(7-methoxyimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)-3-methoxyphenyl)piperazin-1-yl)ethanone | Drug Info |
| CDK2 --- CDK1 | N6-benzyl-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- CDK1 | N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide | Drug Info |
| CDK2 --- CDK1 | 4-[5-(3-Methanesulfonylamino-phenyl)-2H-pyrazol-3-ylamino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-[2-(2-Hydroxy-ethoxy)-ethyl]-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic Acid(4-Fluoro-phenyl)-amide | Drug Info |
| CDK2 --- CDK1 | 6-Cyclohexylmethoxy-N*2*-(4-methylsulfanyl-phenyl)-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK4 | [4-(6-Methyl-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL433068 | Drug Info |
| CDK2 --- CDK4 | 3-((2,5-Dichloro-phenyl)-{2-[4-(3-dimethylamino-2-hydroxy-propoxy)-phenylamino]-pyrimidin-4-yl}-amino)-propionitrile | Drug Info |
| CDK2 --- CDK4 | 1-{4-[4-(2-Chloro-phenylamino)-pyrimidin-2-ylamino]-phenoxy}-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- Cyclin E | 2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-N6-((3'-chlorobiphenyl-4-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | 3-(4-tert-Butylamino-2-trifluoromethyl-quinazolin-6-yl)-benzamide | Drug Info |
| CDK2 --- Cyclin E | (4-Butylsulfanyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-phenyl-methanone | Drug Info |
| CDK2 --- Cyclin E | (3-Isopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-urea | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-methoxy-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N6-(2,3'-bithiophen-5-ylmethyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- GSK3 | 4-[5-(4-Amino-cyclohexylamino)-3-chloro-pyrazolo[1,5-a]pyrimidin-7-ylamino]-N,N-dimethyl-benzenesulfonamide | Drug Info |
| CAII --- CAI | 1-(3-(2-bromophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Methylamino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid [4-(3-sulfamoyl-phenylsulfamoyl)-phenyl]-amide | Drug Info |
| Ckit --- BRaf | 4-((4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)-1-methyl-1H-pyrazol-5-ylamino)methyl)-N-methylpicolinamide | Drug Info |
| CAII --- CAI | 3-Pentafluorobenzenesulfonylamino-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| COX2 --- 5LOX | 2-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-4-(4-fluoro-phenyl)-oxazole-5-sulfonic acid amide | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[4-(4-sulfamoyl-phenylamino)-pyrimidin-2-yl]-acetamide | Drug Info |
| COX2 --- 5LOX | 3-(4-Isopropylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | 3-(4-Methoxyphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | Diethyl 2-(2-(3-(4-(ethoxycarbonyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate | Drug Info |
| CSrc --- CABL | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-[18F]fluoroethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Drug Info |
| CAII --- CAI | 3-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-dimethylamino-1-methyl-ethyl ester | Drug Info |
| CSrc --- CABL | N-(3-bromophenyl)-1-(2-chloro-2-(4-fluorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-(4-(4-fluoro-3-methylphenyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide | Drug Info |
| CSrc --- CABL | (E)-3-(2-(6-(cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[2-(carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CSrc --- CABL | N-Benzyl-1-(2-chloro-2-phenylethyl)-6-(methylsulfonyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (sulfamoylamino)benzene | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(2-methoxyethoxy)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 2-Amino-N-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-acetamide | Drug Info |
| CSrc --- CDK4 | Granulatimide | Drug Info |
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