Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- Cyclin E | 2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propane-1,2-diol | Drug Info |
| CDK2 --- Cyclin E | 3-{6-[(Biphenyl-4-ylmethyl)-amino]-9-isopropyl-9H-purin-2-ylamino}-propane-1,2-diol | Drug Info |
| CDK2 --- Cyclin E | 3-methyl-5-phenyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- GSK3 | (3-Methoxy-phenyl)-[4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CAII --- CAI | 2-(4-fluorophenyl)-N-(4-sulfamoylphenyl)acetamide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Dimethylamino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | N-(3-Carboxybenzyl)(4-sulphonamidephenyl)ethanamine | Drug Info |
| Ckit --- BRaf | 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-(2,3-dihydro-1H-inden-5-yl)urea | Drug Info |
| CAII --- CAI | 5-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-ylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| COX2 --- 5LOX | 1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-thiophen-3-yl-propenone | Drug Info |
| CAII --- CAI | 2,6-Dimethyl-4-phenyl-1-{[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
| COX2 --- 5LOX | 2,6-Dimethyl-4-[2-(2-trifluoromethyl-phenyl)-vinyl]-phenol | Drug Info |
| CAII --- CAI | 4-Hydroxymethyl-N-(2-methylamino-acetyl)-benzenesulfonamide | Drug Info |
| COX2 --- 5LOX | 1-(4-trifluoromethoxyphenyl)-3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | SID16953277 | Drug Info |
| CSrc --- CABL | 9-(2-(1H-indazol-4-yl)vinyl)-N-(4-(dimethylphosphoryl)phenyl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | {{2-[Carboxymethyl-(2-{carboxymethyl-[N'-(4-sulfamoyl-phenyl)-hydrazinocarbonylmethyl]-amino}-ethyl)-amino]-ethyl}-[N'-(4-sulfamoyl-phenyl)-hydrazinocarbonylmethyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | 9-(2-chloro-6-methylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info |
| CSrc --- CABL | N-(5-(4-nitrobenzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-benzenesulfonic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| CSrc --- CABL | 4-(1-(2-bromo-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine | Drug Info |
| CAII --- CAI | 2-Methylamino-N-(2-sulfamoyl-benzothiazol-6-yl)-acetamide | Drug Info |
| CSrc --- CABL | 3-Amino-1-methyl-6-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrazolo[4,3-c]pyridin-4(5H)-one | Drug Info |
| CAII --- CAI | SID22412083 | Drug Info |
| CSrc --- Ckit | N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)pyrimidine-5-carboxamide | Drug Info |
| CAII --- CAI | phenoxyarsonous acid | Drug Info |
| DHFR --- TYMS | (2S)-2-(5-{[(2-Amino-4-oxo-3,4-dihydro[1]benzothieno-[2,3-d]pyrimidin-5-yl)methyl]amino}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid | Drug Info |
| CAII --- CAI | 4,5-Dichloro-6-(heptadecafluorooctane-1-sulfonylamino)-benzene-1,3-disulfonic acid diamide | Drug Info |
| DHFR --- TYMS | N-[4-[(2-amino-6-ethyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]-pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR --- HER2 | 2-cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)acrylamide | Drug Info |
| CAII --- CAI | Ethyl 1-(3-(2-(1,3-dioxo-1,3-diphenylpropan-2-ylidene)hydrazinyl)phenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazole-4-carboxylate | Drug Info |
| EGFR3 --- CD221 | N-(4-methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine | Drug Info |
| CAII --- CAI | Phenyl-(4-sulfamoyl-benzoylamino)-acetic acid | Drug Info |
| EGFR3 --- FGFR1 | 5-(2-diethylamino-ethoxy)-7,12-dioxo-7,12-dihydro-dinaphtho[1,2-b;2',3'-d]furan-6-carboxylic acid methyl ester | Drug Info |
| CAII --- CAI | 5-(4-Trifluoromethanesulfonylamino-benzenesulfonylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| CAII --- CAI | 3-(4-trifluoromethylsulfonamidophenylsulfonamido)-1-benzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-pentyloxy-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| CAII --- CAI | 3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-1,1-diphenyl-urea | Drug Info |
| EGFR3 --- HER2 | CHEMBL438536 | Drug Info |
| CAII --- CAI | 5-Chloro-2-methoxy-N-(5-sulfamoyl-indan-2-yl)-benzamide; hydrate | Drug Info |
| EGFR3 --- HER2 | 5-(Dimethyl-hydrazonomethyl)-N-[1-(3-fluoro-benzyl)-1H-indazol-5-yl]-pyrimidine-4,6-diamine | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| EGFR3 --- HER2 | 2-(3,5-Bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | 2-Amino-N-{[4-(4-sulfamoyl-phenylamino)-pyrimidin-2-ylcarbamoyl]-methyl}-acetamide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(1-benzyl-2,3-dihydro-1H-indol-5-ylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| CAII --- CAI | Sodium Iodide I 125 | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(thiophen-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
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