Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK4 --- Cyclin E | N-[3-(5-methoxythien-2-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-2,2-dimethylhydrazinecarboxamide | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9R,10S,11S,14S,17R)-3,7,12-Trihydroxy-10-(R)-methyl-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(2-hydroxyethylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | (S)-4-Methylsulfanyl-2-(4-sulfamoyl-benzoylamino)-butyric acid | Drug Info |
| COX --- MMP-9 | 4,4'-(1E,1'E)-2,2'-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol) | Drug Info |
| CAII --- CAI | 1-(3-(4-chlorophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| COX2 --- 5LOX | 4-[2-(4-Butoxy-phenyl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | 5-[4-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| COX2 --- 5LOX | INDOMETHACIN | Drug Info |
| CAII --- CAI | 3-(2-Methylamino-acetylamino)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CSrc --- CABL | Glu-Pro-Gln-F2Pmp-Glu-Glu-Ile-Pro-Ile-Tyr-Leu | Drug Info |
| CAII --- CAI | N-(2-Iodo-4-sulfamoyl-phenyl)-2-methylamino-acetamide | Drug Info |
| CSrc --- CABL | 4-((5-(3-chloro-4-methylphenyl)furan-2-yl)methylene)-1-(3,4-dimethylphenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | azepane-1-sulfonamide | Drug Info |
| CSrc --- CABL | N-butyl-1-(2-chloro-2-(4-chlorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 3-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid | Drug Info |
| CSrc --- CABL | 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6-(morpholinomethyl)pyridin-3-yl)naphthalen-1-yl)urea | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-iodo-4-sulfamoyl-phenyl)-acetamide | Drug Info |
| CSrc --- CD221 | 2-(1H-Indol-3-yl)-N'-(4-iodobenzoyl)-2-oxoacetohydrazide | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- TEK | 1H-Indole-2-carboxylic acid (4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxy-phenyl)-amide | Drug Info |
| CAII --- CAI | {(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| DHFR --- TYMS | 2-(4-{[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-methyl-amino]-methyl}-benzoylamino)-pentanedioic acid | Drug Info |
| CAII --- CAI | 4-(4-trifluoromethylsulfonamidophenylsulfonamido)-1-benzenesulfonamide | Drug Info |
| EGFR --- HER2 | 2-(2-chlorobenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile | Drug Info |
| CAII --- CAI | 4-Chloro-3-sulfamoyl-N-(4-sulfamoyl-phenyl)-benzamide | Drug Info |
| EGFR --- Src | N-Methoxy-3-{2-[3-(2-methoxycarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide | Drug Info |
| CAII --- CAI | [{2-[[(2,3-Dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| EGFR3 --- CSrc | 7-((S)-1-benzyl-2-hydroxyethylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylaminopyrazolo[1,5-a]pyrimidine-3-carboxamide | Drug Info |
| CAII --- CAI | 4-Benzoyl-1-(3-((4-hydroxyphenyl)diazenyl)phenyl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-((4-((2-(methylsulfonyl)ethylamino)methyl)phenyl)ethynyl)pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-(4-Sulfamoyl-benzoylamino)-pentanedioic acid | Drug Info |
| EGFR3 --- HER2 | 2-(2-(4-Bromobenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | {[(2,3-Dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((4-((isopropylamino)methyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| CAII --- CAI | (S)-3-Phenyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| EGFR3 --- HER2 | Tyrosol caffeate | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethyl]-benzamide | Drug Info |
| EGFR3 --- HER2 | 4-(3-Chloro-4-fluoro-phenylamino)-5-[1-[3-methyl-5-(morpholine-4-carbonyl)-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one | Drug Info |
| CAII --- CAI | Sulfamic acid butyl ester | Drug Info |
| EGFR3 --- HER2 | 2-(4-Fluorophenyl)-N-(phenylsulfonyl)acetamide | Drug Info |
| CAII --- CAI | 4-Chloro-3-sulfamoyl-N-(5-sulfamoyl-1H-1lambda*4*-[1,3,4]thiadiazol-2-yl)-benzamide | Drug Info |
| EGFR3 --- HER2 | 7-(4-(4-Fluorobenzylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | ((2-{2-[2-(Carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethoxy]-ethoxy}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-amide | Drug Info |
| CAII --- CAI | 2-Amino-N-{2-[6-(2-hydroxy-ethoxy)-benzothiazole-2-sulfonylamino]-2-oxo-ethyl}-acetamide | Drug Info |
| CAII --- CAI | 2-Methylamino-N-{4-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenesulfamoyl]-phenyl}-acetamide | Drug Info |
| CAII --- CAI | 3-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
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