Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | GW280670X | Drug Info |
| CDK2 --- CDK1 | 2-Amino-5-({3-[(4-chlorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl}-methyl)-1,3-thiazol-4-ol | Drug Info |
| CDK2 --- CDK1 | 4-(2-(1-chloro-7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N,N-Dimethyl-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(6-bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CDK2 --- CDK4 | (4-butoxy-1H-indazol-5-yl)(2,6-difluoro-4-methylphenyl)methanone | Drug Info |
| CDK2 --- CDK4 | (3,5-Dimethyl-phenyl)-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL317378 | Drug Info |
| CDK2 --- Cyclin E | Indenopyrazoles derivative | Drug Info |
| CDK2 --- Cyclin E | [5-(5-tert-Butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-yl]-carbamic acid benzyl ester | Drug Info |
| CDK2 --- Cyclin E | 1-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-piperidin-4-ol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-(pyridin-2-yl)thiophen-2-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-((S)-3-hydroxy-but-1-ynyl)-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(Biphenyl-4-ylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N-(4-Fluorobenzyl)-2-(trifluoromethyl)quinazolin-4-amine | Drug Info |
| CDK2 --- Cyclin E | 7-fluoro-5-(2-fluorophenyl)-3-methyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- GSK3 | N-(5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | Ethyl-2-((3-(4-benzoyl-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)diazenyl)-3-oxo-3-phenylpropanoate | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Amino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | N-[2-({2-[(aminosulfonyl)amino]ethyl}dithio)ethyl]sulfamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(3-methoxypropyl)picolinamide | Drug Info |
| CAII --- CAI | 4,6-Dinitro salicylic acid | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(diethylamino)ethyl)picolinamide | Drug Info |
| CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-sulfamoyl-benzothiazol-6-yl ester | Drug Info |
| COX2 --- 5LOX | 4-[2-(4-Chloro-phenyl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | N-(2,3-Dichloro-4,6-disulfamoyl-phenyl)-2-methylamino-acetamide | Drug Info |
| COX2 --- 5LOX | BW-755C | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| COX2 --- HRH1 | 11-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethylsulfanyl}-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-(4-sulfamoyl-benzyl)-acetamide | Drug Info |
| CSrc --- CABL | 3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-hydroxy-ethyl ester | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-methoxy-9H-purin-6-amine | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-ethyl)-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | N-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-4-fluorobenzamide | Drug Info |
| CAII --- CAI | 2-phenyl-N-(4-sulfamoylphenethyl)acetamide | Drug Info |
| CSrc --- CABL | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-yloxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | {4-Methyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-pentanoylamino}-acetic acid | Drug Info |
| CSrc --- CD135 | 4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylamino)benzenesulfonamide | Drug Info |
| CAII --- CAI | 4-[4-(1,1,2,2,3,3,4,4,4-nonafluorobutylsulfonamido)phenylsulfonamido]-1-benzenesulfonamide | Drug Info |
| CSrc --- FGFR1 | 4-[3-(2,6-Dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-7-ylamino]-N,N-diethyl-benzamide | Drug Info |
| CAII --- CAI | sodium 4-chlorobenzoate | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | {3-(1H-Imidazol-4-yl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionylamino}-acetic acid | Drug Info |
| EGFR --- HER2 | 3-(3,4-dihydroxyphenyl)-2-(thiophene-2-carbonyl)acrylonitrile | Drug Info |
| CAII --- CAI | sodium 4-(chloromethyl)benzoate | Drug Info |
| EGFR --- Src | 3-{2-[3-(2-Methoxycarbonyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionic acid methyl ester | Drug Info |
| CAII --- CAI | 4-((6R,7S,8S,10R,11S,12S,14S,15R)-3,12-Di(R)-hydroxy-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethyl]-amide | Drug Info |
| EGFR3 --- CSrc | 4-{2-[3-(4-carboxybenzylcarbamoyl)-1-methyl-1H-2-indolyldisulfanyl]-1-methyl-1H-3-indolylcarboxamidomethyl}benzoic acid1.5 H2O | Drug Info |
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