Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | GW276655X | Drug Info |
| CDK2 --- CDK1 | 2-(3,4-dihydroxy-phenyl)-8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | SID124349847 | Drug Info |
| CDK2 --- CDK1 | N-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 6-Cyclohexylmethoxy-N*2*-(4-methoxy-phenyl)-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK1 | GW300660X | Drug Info |
| CDK2 --- CDK4 | 4-[2-(3-Hydroxy-phenylamino)-pyrimidin-4-yl]-3,5-dimethyl-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | TCMDC-138697 | Drug Info |
| CDK2 --- CDK4 | CHEMBL317629 | Drug Info |
| CDK2 --- CDK4 | CHEMBL478409 | Drug Info |
| CDK2 --- Cyclin E | 2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | 6-Benzyl-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | 2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-3-phenyl-propan-1-ol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-(4-methylthiazol-2-yl)thiophen-2-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 3-Ethyl-6-(2-methoxy-benzyl)-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | 4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-nitro-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine-3-carboxamide | Drug Info |
| CDK2 --- GSK3 | 3-[2-(3-Trifluoromethyl-phenylamino)-pyrimidin-4-yl]-pyrazolo[1,5-b]pyridazin-6-ol | Drug Info |
| CAII --- CAI | (Carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| CDK4 --- Cyclin E | ethyl 5-(5-{[(2,2-dimethylhydrazino)carbonyl]amino}-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophene-2-carboxylate | Drug Info |
| CAII --- CAI | N-(5-Chloro-2,4-disulfamoyl-phenyl)-2-methylamino-acetamide | Drug Info |
| Chk --- VEGFR | 3-(1H-indol-2-yl)quinolin-2(1H)-one | Drug Info |
| CAII --- CAI | 1-(3-(2-chlorophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-cyclopropylpicolinamide | Drug Info |
| CAII --- CAI | ({[2-(4-Sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| COX2 --- 5LOX | 2,6-Diethyl-4-(2-pyridin-3-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| COX2 --- 5LOX | 2,6-Dimethyl-4-(2-pyridin-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 3-(3,4-Dihydroxy-phenyl)-2-(4-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| COX2 --- HRH1 | 11-[2-(4-Phenyl-piperazin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | ([2-(Bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| CSrc --- CABL | 6-(2,6-dichlorophenyl)-2-(3-ethylphenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | Drug Info |
| CAII --- CAI | (2S,3R)-3-Hydroxy-2-(4-sulfamoyl-benzoylamino)-butyric acid | Drug Info |
| CSrc --- CABL | N-benzyl-1-(2-bromo-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | N,N-dialkylthio-carbonylsulfenylamino derivative | Drug Info |
| CSrc --- CABL | 6-(2,6-dichlorophenyl)-2-(4-(2-hydroxyethyl)phenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | Drug Info |
| CAII --- CAI | N-(4-chlorophenyl)sulfamide | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(1-methylpiperidin-4-yl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | [[2-(Carboxymethyl-{2-[carboxymethyl-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-ethyl}-amino)-ethyl]-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-acetic acid | Drug Info |
| CSrc --- CABL | N-(2-chlorobenzyl)-6-(methylthio)-1-(2-phenylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | tert-Butyl2-((3-(4-benzoyl-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)diazenyl)-3-oxobutanoate | Drug Info |
| CSrc --- FGFR1 | 7-Oxo-5-phenyl-7H-[2]pyrindine-6-carboxylic acid methyl ester | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-[4-(4-sulfamoyl-phenylamino)-pyrimidin-2-yl]-acetamide | Drug Info |
| DHFR --- TYMS | 2-Amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
| DNPK1 --- PI3K delta | 3-(3-(benzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | Ethyl1-(3-iodophenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazole-4-carboxylate | Drug Info |
| EGFR --- Src | 3-{2-[3-(2-Carbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide | Drug Info |
| CAII --- CAI | N-(4-sulfamoylbenzyl)pivalamide | Drug Info |
| EGFR3 --- CSrc | 4-{2-[3-(4-carboxybenzoyl)-1-methyl-1H-2-indolyldisulfanyl]-1-methyl-1H-3-indolylcarbonyl}benzoic acid2 H2O | Drug Info |
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