Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | rac-2-(4-Methoxy-3-((4-phenethoxybenzamido)methyl)benzyl)butanoic acid | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-5-morpholino-1H-benzo[d]imidazole | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-(4-hydroxy-phenyl)-pyrrolo[2,1,5-cd]indolizin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarbamoyl)benzyl)butanoic acid | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(2-(piperidin-1-yl)ethoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-{6-methyl[3-(4,4,5,5,5-pentafluoropentylsulfanyl)propyl]aminohexyl}-(E)-1-butenyl]phenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(2-(2-(3,5-dimethoxyphenyl)-5-methyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)-2-methoxypropanoic acid | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(4-(2-hydroxypropan-2-yl)phenyl)pyrimidine-5-carbonitrile | Drug Info |
| JNK1 --- JNK3 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(4-Hydroxymethyl-piperidin-1-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-7-yl)pyrimidin-2-amine | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(pyridin-4-ylmethyl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(2,4-Dichloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| VEGFR2 --- Ckit | N3-(6-acetamidopyridin-3-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
| JNK1 --- JNK3 | N-(4-(1H-1,2,3-Triazol-1-yl)phenyl)-4-(3-morpholinophenyl)-pyrimidin-2-amine | Drug Info |
| Erbeta --- ER | 3-(4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| VEGFR2 --- Cmet | 1-Ethyl-N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 2-Bromo-N-[2-((R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-ethyl]-acetamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-propoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 3-Bromo-2-(4-hydroxy-phenyl)-5-methoxy-inden-1-one | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| MEP --- Cathepsin B | 1-((3,5-dichlorophenyl)(p-tolyl)methylene)thiosemicarbazide | Drug Info |
| Erbeta --- ER | 2-Phenyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| VEGFR2 --- CSrc | N-(3-chloro-6-methoxypyridin-2-yl)-7-(3-morpholinopropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| MEP --- Cathepsin B | Z-Phe-Ala-H | Drug Info |
| Erbeta --- ER | 3-(3-Bromo-4-hydroxy-phenyl)-2,2-dimethyl-2H-benzo[1,4]oxazine-5,7-diol | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-tert-butyl-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| MEP --- Cathepsin B | (R)-N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(3-aminopyrrolidin-1-yl)thiazol-4-yl)benzamide | Drug Info |
| Erbeta --- ER | Poricotriol A[(20R)-3,4-seco-24-methyllanosta-4(28),7,9-(11),24(241)-tetraene-3,16alpha,21-triol] | Drug Info |
| VEGFR2 --- CSrc | CHEMBL371688 | Drug Info |
| MEP --- Cathepsin B | (S)-N-(3-(3-(1H-pyrazol-4-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)benzamide | Drug Info |
| Erbeta --- ER | (E)-7,8-Bis-(4-hydroxy-phenyl)-dec-7-enoic acid methyl-[3-(4,4,5,5,5-pentafluoro-pentylsulfanyl)-propyl]-amide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-chloropyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| MEP --- Cathepsin B | 4'-[Methyl-(1-methyl-pyrrolidin-3-yl)-amino]-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| Erbeta --- ER | 8-(3-methylbutyl)naringenin | Drug Info |
| VEGFR2 --- FGFR1 | 5-[6-(5-Dimethylaminomethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-2,4-difluoro-N-methoxy-benzamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(morpholine-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-6-(3-(piperidin-1-yl)propoxy)-1H-indol-3-yl)acetamide | Drug Info |
| VEGFR2 --- FGFR1 | CHEMBL1762528 | Drug Info |
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(2-hydroxyethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid amide | Drug Info |
| CDK1 --- CDK4 | (5-Piperazin-1-yl-pyridin-2-yl)-[4-(3-trifluoromethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CDK1 --- GSK3 | (E)-3-(6-Oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-benzo[2,3]azepino[4,5-b]indol-2-yl)-acrylic acid methyl ester | Drug Info |
| CDK1 --- GSK3 | 7-Butyl-6-(4-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | N-(3-chlorophenyl)-6-(5-{[3-(piperidin-1-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one | Drug Info |
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