Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- TEK | (E/Z)-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| H3 --- SERT | 7-(3-(4,4-difluoropiperidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- TEK | 7-[(furan-3-yl)carbonyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| HD6 --- HDAC4 | ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate | Drug Info |
| EGFR3 --- HER2 | 4-Thiomorpholin-4-yl-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-[2-hydroxy-6-(1H-tetrazol-5-yl)-benzoyl]-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| VEGFR2 --- TEK | N-(2-methoxy-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide | Drug Info |
| HDAC1 --- HD6 | ethyl 2-(5-(2-(4-methoxyphenylamino)-2-oxoethyl)thiophen-2-yl)-2-oxoethyl trithiocarbonoate | Drug Info |
| EGFR3 --- HER2 | DDD01067522 | Drug Info |
| PKCA --- NPKC delta | (E)-{2-(hydroxymethyl)-4-[4-methyl-3-(methylethyl)pentylidene]-5-oxo-2,3-dihydrofur-2-yl}methyl 4-hydroxybenzoate | Drug Info |
| VEGFR2 --- TEK | CEP-7055 | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(2-(4-(2-(dimethylamino)ethoxy)phenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | (4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine | Drug Info |
| PKCA --- NPKC delta | dihexan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info |
| VEGFR2 --- TEK | SID124349931 | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(4-((perfluorobenzyloxyimino)methyl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-phenethyloxy-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-biphenyloxypropoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- TEK | 4-chloro-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | 4-[(2-Hydroxy-ethyl)-methyl-amino]-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E)-3-(Furan-2-yl)acryloyl]-7-(2-{5-methyl-2-[(1E)-5-methylhexen-1-yl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| VEGFR2 --- VEGFR1 | (5-Ethanesulfonyl-2-methoxy-phenyl)-[5-(3-thiophen-2-yl-phenyl)-oxazol-2-yl]-amine | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-2-(5-acetamidopentyl)-11-isobutyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methanesulfonate | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(7-chloro-8-methyl-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(4-Chloro-phenylsulfanyl)-4-pyridin-4-ylmethyl-phthalazine | Drug Info |
| HDAC1 --- HDAC2 | 8-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-2-oxo-octanoic acid methylamide | Drug Info |
| EGFR3 --- VEGFR1 | 2-(Methyl-{4-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzyl}-amino)-ethanol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-bis(4-methoxyphenyl)allyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | CHEMBL150606 | Drug Info |
| HDAC1 --- HDAC2 | 2-Oxo-nonanedioic acid 1-methylamide 9-quinolin-3-ylamide | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (1'S*,5'R*)-6-(5-Heptyl-2-Iodo-4-oxocyclopent-2-enyloxy)hexanoic Acid | Drug Info |
| VEGFR2 --- VEGFR1 | (3,5-Dimethoxy-phenyl)-[4-(2-phenyl-imidazol-1-yl)-pyrimidin-2-yl]-amine | Drug Info |
| HDAC1 --- HDAC2 | 7-(2-(4-fluorophenyl)oxazol-5-yl)-N-hydroxyheptanamide | Drug Info |
| Erbeta --- ER | 1-(2-{4-[8-Fluoro-4-(4-fluorophenyl)-2,3-dihydro-benzo[b]-oxepin-5-yl]-phenoxy}-ethyl)-pyrrolidine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)phenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(quinolin-3-yl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 9a-(4-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-5-(pyridin-4-ylmethyl)pyrido[2,3-d]pyridazin-8-amine | Drug Info |
| HDAC1 --- HDAC4 | (S)-tert-butyl 1-(tert-butylamino)-7-mercapto-1-oxoheptan-2-ylcarbamate | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-chloro-4-(3-(3-phenyl-7-propylbenzofuran-6-yloxy)propylthio)phenyl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HDAC4 | (S)-tert-butyl 7-mercapto-1-oxo-1-(quinolin-3-ylamino)heptan-2-ylcarbamate | Drug Info |
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