Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carbohydrazide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-piperidin-4-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| HDAC1 --- HD6 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(4-((cyclopropylamino)methyl)styryl)-6-methylpyrimidin-4-amine | Drug Info |
| PPAR gamma --- 5LOX | (R)-2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-3-chlorobenzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Chloro-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-bis(4-bromophenyl)allyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(4-phenylthiazol-2-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- MCSF | (4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-methyl-amine; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-4-ethoxy-2-fluoro-benzyl}-butyric acid | Drug Info |
| HDAC1 --- HDAC2 | 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one | Drug Info |
| Erbeta --- ER | (4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-(4-methoxy-phenyl)-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-((1-methyl-5-(4-(pyrrolidin-1-yl)phenyl)-1H-pyrazole-3-carboxamido)methyl)phenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-(Biphenyl-4-sulfonyl)-2-oxo-octanoic acid methylamide | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-phenyl-3,4-dihydro-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-6-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-aminobiphenyl-3-yl)nicotinamide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-ethoxy-3-(4-(3-(4-phenoxyphenoxy)propoxy)phenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-sec-Butoxy-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | (13S,17S)-4-(3-Hydroxy-propyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| PPAR gamma --- PPAR delta | [4-([1,1';3',1'']terphenyl-5'-ylmet hoxy)-phenoxy]-acetic acid | Drug Info |
| HDAC1 --- HDAC4 | 3-[4-(3,4-Dimethoxy-phenylsulfamoyl)-phenyl]-N-hydroxy-acrylamide | Drug Info |
| Erbeta --- ER | 4-ethynyl-2-(4-hydroxyphenyl)quinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-5-(trifluoromethyl)biphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HER2 --- CD221 | cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenyl)-5,7-dimethylbenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | 1-Cyclohexyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| Erbeta --- ER | 1-[4-(1-Methyl-piperidin-4-yl)-phenyl]-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(4-bromo-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(dimethylamino)piperidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-(4-piperidin-1-ylmethyl-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(1-(4-cyclohexylbutyl)-3-(2-methoxyphenyl)ureido)ethyl)phenylthio)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | 3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-5-(4-(dimethylamino)butanamido)benzoic acid | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-{4-[(S)-2-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-chroman-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(2-chloro-4-(4-fluorophenoxy)phenoxy)propoxy)phenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate | Drug Info |
| Erbeta --- ER | 3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-Ethyl-5-[3-(2-propyl-4-trifluoromethylsulfanyl-phenoxy)-propoxy]-2,3-dihydro-benzofuran-2-carboxylic acid | Drug Info |
| JNK1 --- JNK3 | SID103905197 | Drug Info |
| Erbeta --- ER | 8-(2,2-dimethylpropyl)naringenin | Drug Info |
| PPAR gamma --- PPAR delta | (Z)-2-(2-methyl-4-(6-phenyl-4-(quinolin-3-yl)hex-2-en-5-ynyloxy)phenoxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(5-methyl-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide | Drug Info |
| Erbeta --- ER | 2-(5-bromo-6-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(pent-2-ynyloxy)-4-((3-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | 5-(difluoromethyl)-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | (4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-phosphonic acid diethyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2-methyl-4-(3-(2-propyl-4-(trifluoromethyl)phenoxy)propoxy)phenoxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-(2-cyanovinyl)-6-ethoxypicolinamide | Drug Info |
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