Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | N1-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N8-hydroxyoctanediamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(3-isopropylphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(3-thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-3-carboxylic acid | Drug Info |
| HDAC1 --- HD6 | (R)-N-hydroxy-3-(3-(1-(1-phenylethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 4-(4,4-Dihydroxy-piperidin-1-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E)-4-Ethoxybutenoyl]-7-(2-{5-methyl-2-[(1E)-5-methylhexen-1-yl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| HDAC1 --- HD6 | N-Ethyl S-2-(4-Methoxy-phenyl)-2-oxoethyl Dithiocarbamate | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(5-(pyridin-2-yloxy)naphthalen-2-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| PPAR gamma --- PPAR delta | 6-((1R,5R)-5-heptyl-4-oxocyclopent-2-enyloxy)hexanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 1-Benzyl-1H-indole-3-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| EGFR3 --- VEGFR1 | 2-({4-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzyl}-methyl-amino)-ethanol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-5-(3-(3-(4-cyclopentyl-2-propylphenoxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC2 | 8-(biphenyl-4-yloxy)-2-oxo-octanoic acid methyl ester | Drug Info |
| Erbeta --- ER | (1S,12R,14R)-5-hydroxy-10-methyl-14-propyltetracyclo[10.2.1.0^{1,9}.0^{3,8}]pentadeca-3,5,7,9-tetraen-11-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(((2-(2,4-dimethylphenylamino)-2-oxoethyl)(furan-2-ylmethyl)amino)methyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 5-Methyl-1H-indole-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | 4-{8-Methoxy-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[b]oxepin-4-yl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(cyclohexanecarbonyl)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC2 | N-(4-aminobiphenyl-3-yl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide | Drug Info |
| Erbeta --- ER | (S)-9a-butyl-6-ethyl-1-fluoro-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(4-methoxy-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(furan-3-yl)phenyl)-4-((3,4-dimethoxyphenylamino)methyl)benzamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-(4-{2-[4-(2-Hydroxy-ethyl)-piperidin-1-yl]-ethoxy}-phenyl)-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S,Z)-2-ethoxy-3-(4-(3-(4-fluorophenyl)-3-phenylallyloxy)phenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) | Drug Info |
| Erbeta --- ER | SID26668650 | Drug Info |
| PPAR gamma --- PPAR delta | {2-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-acetic acid | Drug Info |
| HER2 --- CD221 | cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chloro-5-methylbenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | 9a-butyl-6-propyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(Naphthalen-2-yloxy)-ethoxy]-benzyl}-malonic acid monomethyl ester | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-propyl-2H-benzo[1,4]oxazin-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-(4-(4-fluorophenoxy)benzylcarbamoyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-phenylquinazolin-2-amine | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-6-(2-(piperidin-1-yl)ethoxy)-1H-indol-3-yl)acetamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-Ethoxy-3-[4-((E)-5-phenyl-pent-2-en-4-ynyloxy)-phenyl]-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-methoxyethyl)-3-(2-phenylacetamido)thiophene-2-carboxamide | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{3-[(4-Adamantan-1-yl-benzoylamino)-methyl]-5-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
| JNK1 --- JNK3 | trans-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-4-methoxycyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-4-vinylquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-((Piperidin-1-yl)methanone)phenyl)-5-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| JNK1 --- JNK3 | 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | (E)-3-[4-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-phenyl]-N,N-dimethyl-acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(4-methoxybut-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-benzylpiperazin-1-yl)-3-chlorophenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | 6-(4-hydroxy-3-methoxyphenyl)naphthalen-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{1-[3-(4-Benzoyl-2-propyl-phenoxy)-propyl]-1H-indol-5-yloxy}-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | 2-(2-(naphthalen-1-yloxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | SID87348867 | Drug Info |
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