Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- TEK | 5-(((3-fluoro-5-(trifluoromethyl)phenyl)carbonyl)amino)-2-methyl-N-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-5-pyrimidinyl)benzamide | Drug Info |
| MMP13 --- MMP1 | N-Hydroxy-2-(4-methoxy-phenylmethanesulfonyl)-2-methyl-3-phenyl-propionamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-7-propylbenzo[d]oxazol-5-ol | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(biphenyl-4-yloxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | 4-(2-phenyl-1H-indol-3-yl)phenol | Drug Info |
| VEGFR2 --- TEK | 7-tert-Butyl-5-[4-(4-methoxy-phenoxy)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| MMP13 --- MMP9 | 2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyacetamide | Drug Info |
| Erbeta --- ER | 8-Chloro-7-hydroxy-3-(4-hydroxy-phenyl)-naphthalene-1-carbonitrile | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-(trifluoromethylthio)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| MMP2 --- HER2 | (1S,2S,5RS)-N-hydroxy-5-(2-morpholino-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 4-((1R,2R,5S)-5-Hydroxymethyl-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| VEGFR2 --- TEK | 7-amino-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-11-benzoyl-8-[3-(3,5-dibromo-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- mRNA of AR | (8R,9S,10S,13S,14S,17S)-13-methyl-3-phenyl-10-vinyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| MMP2 --- MMP13 | 1-cyclopropyl-N-hydroxy-4-(4-(4-phenylpiperazin-1-yl)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Cyano-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-{3-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-piperidin-1-yl}-ethanone | Drug Info |
| VEGFR2 --- VEGFR1 | N1-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazine-1,7-diamine | Drug Info |
| MMP2 --- MMP13 | 4-(4-(((S)-3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)-N-((R)-1-(pyridin-4-yl)ethyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-((5-(((3-aminopropyl)(1-(3-chlorobenzyl)-2-oxopyrrolidin-3-yl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-3-methyl-1-(2-(pyridin-4-yl)ethyl)-1Hpyrazole-5-carboxamide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(4-(4-acetylphenyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(4-Benzyloxy-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(pyridin-2-ylmethyl)-2-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(2-methoxyethyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(4-Methoxy-benzylsulfanyl)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | (4-Chloro-2-fluoro-phenyl)-[6-methoxy-7-(1-methyl-piperidin-4-yloxy)-quinazolin-4-yl]-amine | Drug Info |
| MMP2 --- MMP13 | 1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbo-nyl-3,5,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-naphthacen-4-trimethylammonium iodide | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(4-Benzyloxy-phenyl)-2-butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | 2-Phosphonomethyl-N-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(3-Phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-1-(3-piperidin-1-yl-propyl)-1H-pyridin-2-one | Drug Info |
| MMP2 --- MMP3 | (R)-2-[(S)-1-((S)-4-Guanidino-1-phenylcarbamoyl-butylcarbamoyl)-nonylamino]-propionic acid | Drug Info |
| Ftase --- FPTase | 2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-yl]-benzoyl-amino}-4-methylsulfanyl-butyric acid methyl ester; hydrochloride | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(4-chlorophenyl)benzamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-2-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetylamino}-3-methyl-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyramide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(cyclohexylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((S)-3,7-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-4-ylmethylamino)-N-(quinolin-2-yl)isothiazole-3-carboxamide | Drug Info |
| MMP2 --- MMP8 | (cyclobutylamino)carbonylphosphonic acid | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| MMP2 --- MMP9 | N-ethyl-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| Ftase --- FPTase | N-(4H-Benzo[1,3]dioxin-6-yl)-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
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