Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carboxylic acid isopropylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(3-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| ABL --- Src | 6-Methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| CAII --- CAI | (2-{[(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(4-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| ABL --- Src | 6-Methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-thiomorpholinobutyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | 4-(3,5-dichloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpiperazin-1-ylsulfonyl)methyl)styryl)nicotinonitrile | Drug Info |
| FGFR --- Src | 6-(2,6-Dichloro-phenyl)-N*2*-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine | Drug Info |
| H3 --- SERT | (6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophen-3-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | (R)-N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-((1-(2-methoxyethyl)pyrrolidin-2-yl)ethynyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 5-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-pyridin-2-ylamine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenoxy-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dichloro-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylurea | Drug Info |
| PI3K gamma --- PI3K delta | 2-methyl-2-(4-(3-methyl-2-oxo-8-(pyridin-3-ylethynyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| H3 --- SERT | 4-(2-chlorophenyl)-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | 4-(1H-Imidazol-4-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1213118 | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3'-nitro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| HD6 --- HDAC2 | 4-(((R)-2-benzyl-3,6-dioxopiperazin-1-yl)methyl)-N-hydroxybenzamide | Drug Info |
| EGFR3 --- HER2 | (Z)-3-[3-(4-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide | Drug Info |
| PKCA --- NPKC delta | 3-(8-Amino-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID24831583 | Drug Info |
| HDAC1 --- HD6 | 6-(9H-carbazol-9-yl)-N-hydroxyhexanamide | Drug Info |
| EGFR3 --- HER2 | SID124350111 | Drug Info |
| PKCA --- NPKC delta | 17,20,23-trimethyl-4,14,17,20,23,26-hexaazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-benzyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| HDAC1 --- HD6 | (S)-2-(8-hydroxycarbamoyl-octanoylamino)-3-[1,1':4',1'']terphenyl-4-yl-propionic acid methyl ester | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyanoquinolin-6-yl)but-2-ynamide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-1,1-dioxo-1lambda*6*-thiepan-4-yl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | 6-fluoro-2-methyl-9H-carbazole | Drug Info |
| HDAC1 --- HD6 | (6R,9R,12R,16S)-6-isopropyl-16-((E)-4-mercapto-but-1-enyl)-9,12-dimethyl-1-oxa-4,7,10,13-tetraaza-cyclohexadecane-2,5,8,11,14-pentaone | Drug Info |
| EGFR3 --- HER2 | 1-(2-chloroethyl)-3-{[4-(3-chlorophenyl)amino]quinazolin-6-yl}urea | Drug Info |
| PPAR delta --- LXRalpha | 2-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-benzo[d]imidazol-5-yl)acetic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-(3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)butyl)-1H-imidazole-2-carboxamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-[3-(4-methoxy-phenylsulfamoyl)-phenyl]-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 1-(2-Chloroethyl)-1-nitroso-3-{[4-(3-chlorophenyl)amino]quinazolin-6-yl}urea | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-7-(2-{5-Methyl-2-[(1E)-5-methylhexen-1-yl]oxazol-4-yl}ethoxy)-2-[(2E)-3-(thiophen-2-yl)acryloyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-(methoxy)-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| HDAC1 --- HD6 | (R)-N-hydroxy-3-(3-(1-(piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| PPAR gamma --- PPAR delta | {3-Chloro-4-[3-(3-phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-isobutyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{3-[(pyridine-3-carbonyl)-amino]-phenyl}-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- VEGFR1 | (1H-Indol-5-yl)-(2-{4-[(2-pyridin-1-yl-ethylamino)-methyl]-phenyl}-thieno[3,2-b]pyridin-7-yl)-amine | Drug Info |
| PPAR gamma --- PPAR delta | 5-(3-(3-(4-(3,4-dichlorophenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
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