Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MEP --- Cathepsin B | (1S,2S)-2-bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one | Drug Info |
| PR --- mRNA of AR | 6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime | Drug Info |
| Erbeta --- ER | (R)-1-(2-{4-[(2S,3R)-6-Hydroxy-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-2-yl]-phenoxy}-ethyl)-pyrrolidin-3-ol | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-1-oxo-3-(3-(pyridin-4-yl)phenyl)propan-2-yl)benzamide | Drug Info |
| PR --- mRNA of AR | 5-bromo-4-methoxy-2-(((1S,4R)-2,2,4-trimethyl-6-methylenecyclohexyl)methyl)phenol | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-2-phenoxy-ethanone | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| PR --- mRNA of AR | 1,6,8,8-Tetramethyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | (6S,6aR,10aS)-6-(4-hydroxyphenyl)-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-2-ol | Drug Info |
| MEP --- Cathepsin B | (R)-3-(2,3-difluorobenzylsulfonyl)-N-(1-cyanocyclopropyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamide | Drug Info |
| PR --- mRNA of AR | 2,2,4-trimethyl-6-(5-nitrothiophen-2-yl)-1,2-dihydroquinoline | Drug Info |
| Erbeta --- ER | 2-butyl-5,7-dihydroxy-3-(4-hydroxyphenyl)-3H-quinazolin-4-one | Drug Info |
| Met --- VEGFR | N1-(3-fluoro-4-(2-(pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| PR --- mRNA of AR | 5-(4-(1-(hydroxyimino)-2,2-dimethylpropyl)phenyl)-1-methyl-1H-pyrrole-2-carbonitrile | Drug Info |
| Erbeta --- ER | 2-phenyl-1,2'-spirobi[1H-indene]-5'-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-phenyl-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | epi-phelligrin A | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| Renin --- Cathepsin D | (S)-4-(2-amino-6-phenoxyquinazolin-3(4H)-yl)-N,4-dicyclohexyl-N-methylbutanamide | Drug Info |
| Erbeta --- ER | 3,5-dichloro-3'-fluoro-4'-hydroxy-biphenyl-4-carbaldehyde oxime | Drug Info |
| MMP1 --- MMP3 | (R)-2-[4-(4-Chloro-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-phenethylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| S5AR --- SRD5A2 | 1-{4-[4,5-Dihydroxy-6-hydroxymethyl-3,4,5,6-tetramethyl-3-(3,4,5-trihydroxy-2,4,5,6,6-pentamethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2,6-dihydroxy-phenyl}-3-(3-hydroxy-4-methoxy-phenyl)-propan-1-one | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-1-(4-(2-(piperidin-1-yl)ethoxy)benzoyl)-1H-indol-3-yl)acetamide | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-N*1*-[(S)-1-(1H-imidazol-2-yl)-3-methyl-butyl]-2-isobutyl-succinamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-hydroxy-phenyl)-amide | Drug Info |
| Erbeta --- ER | (S)-4-methyl-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(4-(pivaloyloxy)phenyl)-2H-chromen-7-yl pivalate | Drug Info |
| MMP1 --- MMP3 | (2R,3S)-N*1*-Hydroxy-N*4*-[(S)-1-(2-methoxy-ethyl)-2-oxo-azepan-3-yl]-2-methyl-3-octyl-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-2-yl ester | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-(4-hydroxy-phenyl)-pyrrolo[2,1,5-cd]indolizin-5-ol | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-phenylacetamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-diethyl-5-isopropyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 3-(2-chlorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one | Drug Info |
| MMP13 --- MMP1 | [2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-phenyl-butyl]-[4-(2-ethoxy-benzyl)-benzyl]-phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-6-bromo-9a,11a-dimethyl-1-(3-methylbutanoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| Erbeta --- ER | rac-6-bromo-9a-ethyl-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| MMP13 --- MMP1 | 4-(4-But-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,7R)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | 1-Benzyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP13 --- MMP1 | (S)-tert-butyl 4-(4-(3-(hydroxycarbamoyl)-2,2-dimethylthiomorpholinosulfonyl)phenoxy)but-2-ynylcarbamate | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid biphenyl-4-ylamide | Drug Info |
| Erbeta --- ER | 12-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-7,12-dihydro-benzo[a]anthracene-3,11-diol | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benzyloxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (R)-3-{(2S,3S)-3-[2-(2,6-Diethyl-phenoxy)-acetylamino]-2-hydroxy-4-phenyl-butyryl}-thiazolidine-4-carboxylic acid tert-butylamide | Drug Info |
| Erbeta --- ER | 6-hydroxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b] thio phene | Drug Info |
| MMP13 --- MMP1 | (S)-4-(4-(7-aminohept-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-2-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 2-(3-Ethyl-4-hydroxy-phenyl)-benzo[b]thiophen-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-methoxy-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-yloxy)-quinoline-3-carbonitrile | Drug Info |
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