Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(4-oxo-pentanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| MMP3 --- MMP8 | Carbonic acid ethyl ester 3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl ester | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-oxy-pyridin-3-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| MMP3 --- MMP8 | Oxo-[2-(4'-trifluoromethyl-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | (3-Methyl-5-trifluoromethyl-phenyl)-[4-(2-phenyl-imidazol-1-yl)-pyrimidin-2-yl]-amine | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Cyano-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 1-[4-(4,8-Dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| mTOR --- AKT | N-(6-(2-(4-Methylphenylsulfonamido)pyrimidin-4-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(2-Amino-3-methylsulfanyl-propylamino)-3-methyl-butylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid (FTI1) | Drug Info |
| mTOR --- AKT | N-(6-(5-(4-Methoxyphenylsulfonamido)pyridin-3-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3-Chloro-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | tert-butyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| mTOR --- PI3K gamma | methyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methoxy-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 2-Pyridin-4-yl-1-[4-(11H-10-thia-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-p-tolylurea | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((1-benzyl-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| NET --- SERT | 5-Fluoro-3-piperidin-4-ylmethyl-1H-indole | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-benzyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| NET --- SERT | 3-(4-Bromo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 2-fluoro-ethyl ester | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid carbamoylmethyl-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3,4-dimethoxyphenyl)-4-(4-ethyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | (S)-3-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(Hydroxymethyl)piperidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-4-(3-Aminoazetidin-1-yl)but-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-ethyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((S)-3,10-Dibromo-8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| GSK --- VEGFR | Cyclopropanecarboxylic acid [6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-yl]-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid (4-{3-chloro-4-[(naphthalen-1-ylmethyl)-amino]-phenylamino}-3-cyano-7-ethoxy-quinolin-6-yl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(2-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)pyridin-3-yl)vinyl)-N,N-dipropylbenzenesulfonamide | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(4-(pyridin-4-yl)piperazin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (E)-N-(7-((R)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(3-(naphthalen-2-ylmethyl)morpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| H3 --- SERT | 7-(3-(3,3-difluoroazetidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(1-(thiazol-4-ylmethyl)-1H-indol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-p-tolyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (R)-N-Hydroxy-7-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)heptanamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-ethyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| H3 --- SERT | 4-(2-chlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Fluorophenyl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
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