Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | SID124349952 | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-{(1E)-4-[4-(methylsulfonyl)piperazin-1-yl]but-1-en-1-yl}nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-ethylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4-carboxylic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-Bromo-4-chloro-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| GSK --- VEGFR | Cyclopropanecarboxylic acid [6-(4-chloro-phenyl)-furo[2,3-d]pyrimidin-4-yl]-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-phenyl-thiazol-2-ylmethyl)-phenylamino]-3-cyano-7-methoxy-quinolin-6-yl}-amide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((4-hydroxypiperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(3-(4-methylpiperazin-1-yl)propyl)-3-(5-(thiophen-3-yl)pyridin-3-yl)-1H-indole | Drug Info |
| H3 --- SERT | 7-(3-(4-ethylpiperazin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-phenoxyphenyl)benzamide | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 1-(4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yloxy)ethyl)piperazin-1-yl)ethanone | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645107 | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-(4-Chlorophenylsulfonyl)-2-(4-fluorophenyl)acetamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-4-methyl-benzenesulfonamide | Drug Info |
| H3 --- SERT | 3-(3-methoxyphenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-aminopyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HD6 --- HDAC4 | 2,2,2-trifluoro-1-(5-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(3-(morpholinomethyl)phenyl)pyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 2-(4-hydroxy-benzyl)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| HDAC1 --- HD6 | 1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-carbonyl)thiophen-2-yl)-2,2,2-trifluoroethanone | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(1-methyl-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PKCA --- NPKC delta | 3-(1H-Indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-[4-(N-4-methoxy-phenyl-N-methyl-sulfamoyl)-phenyl]-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(quinolin-4-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PKCA --- NPKC delta | 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-isobutyl-5-methyl-hex-(E)-ylidene]-5-thioxo-tetrahydro-furan-2-ylmethyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)-N-hydroxyhexanamide | Drug Info |
| EGFR3 --- HER2 | {6-[2-(2-Methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-amine | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | Azithromycin-N-benzyltriazolyloctahydroxamic Acid | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyanoquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(4-methoxy-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | GSK182497A | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-{3-[1-[2-(2-Chloro-6-fluoro-phenyl)-ethyl]-3-(2,3-dichloro-phenyl)-ureido]-propyl}-phenoxy)-2-methyl-propionic acid (GW 2433) | Drug Info |
| HDAC1 --- HDAC2 | N9-(4-(4-(2-(dimethylamino)ethyl)phenyl)thiazol-2-yl)-N1-methyl-2-oxononanediamide | Drug Info |
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