Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 5-hydroxy-2-(6-hydroxybenzo[d]isoxazol-3-yl)benzaldehyde oxime | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-(2-((benzylamino)methyl)thiophen-3-yl)-5-cyanopicolinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-amino-5-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxamido]-3-oxa-pentane | Drug Info |
| Erbeta --- ER | N-(2-(4-methoxyphenyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)benzamide | Drug Info |
| JNK1 --- JNK3 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(2-amino-2-methylpropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-chlorobenzamide | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carbaldehyde | Drug Info |
| MEP --- Cathepsin B | [(3-Bromophenyl)-(3-acetoxyphenyl)-ketone]thiosemicarbazone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-methyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MEP --- Cathepsin B | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-1-naphthamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea | Drug Info |
| Erbeta --- ER | (2-Phenyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; hydrochloride | Drug Info |
| MEP --- Cathepsin B | 4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-diazo-acetyl)-butylcarbamoyl]-3-methyl-butyl}-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-Methoxybenzyl)-4-furan-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 3-hydroxy-9-methoxy-4,8,10-trimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-3,3,3-trifluoropropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide | Drug Info |
| DHFR --- VEGFR | 5-[(R/S)-2-(20-Methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Erbeta --- ER | 2-(3-Fluoro-4-hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| MEP --- Cathepsin B | 1-((3,5-bis(trifluoromethyl)phenyl)(thiophen-2-yl)methylene)thiosemicarbazide | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-5-(cyclohexyloxy)-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| Erbeta --- ER | 4-[5-(4-hydroxy-phenyl)-4-ethyl-3-(4-methoxy-phenyl)-furan-2-yl]-phenol | Drug Info |
| Met --- VEGFR | N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-1,6-naphthyridin-2(1H)-one | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-(4-hydroxy-phenyl)-5-pentyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| Met --- VEGFR | (S)-N-(3-fluoro-4-(2-(4-((N-(1-methoxypropan-2-yl)acetamido)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-hydroxy-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| Erbeta --- ER | 3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol-3-yl]-3-methylpiperazine-1-sulfonylamino}-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| VEGFR2 --- CDK1 | 4-(3-(4-(isopropoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-3,4-dihydro-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-[(S)-1-(5,6-Dichloro-1H-benzoimidazol-2-yl)-3-methyl-butyl]-N*4*-hydroxy-2-isobutyl-succinamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(2-methyl-1H-indol-5-ylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Erbeta --- ER | 5-hydroxynaphthalen-1-yl 2,4-dichlorobenzoate | Drug Info |
| MMP1 --- MMP3 | 2-[(S)-1-((R)-2-Hydroxycarbamoylmethyl-4-methyl-pentanoylamino)-3-methyl-butyl]-5-phenyl-1H-imidazole-4-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- CDK4 | GW683768X | Drug Info |
| Erbeta --- ER | [4-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP8 | (2R,3S)-2-Cyclopentyl-N*4*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*1*-hydroxy-3-isobutyl-succinamide | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-(2-(dimethylamino)ethyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Erbeta --- ER | 2-(5-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol | Drug Info |
| MMP1 --- MMP9 | 1H-Pyrazole-4-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| VEGFR2 --- Cmet | 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(2-methoxyphenyl)butanamide | Drug Info |
| Erbeta --- ER | [2-(4-{1-[4-(2-Diethylamino-ethoxy)-phenyl]-hept-1-enyl}-phenoxy)-ethyl]-diethyl-amine | Drug Info |
| MMP13 --- MMP1 | 4-{(R)-Carboxy-[5-(4'-methylphenyl)-thiophene-2-sulfonylamino]-methyl}-piperidine-1-carboxylic Acid iso-Propyl Ester | Drug Info |
| VEGFR2 --- Cmet | 2-(4-(7-(2-fluoro-4-(3-oxo-3-(phenylamino)propanamido)phenoxy)thieno[3,2-b]pyridine-2-carbonyl)-1H-imidazol-1-yl)acetic acid | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-6-ol | Drug Info |
| MMP13 --- MMP1 | (3S,4R)-3-Hydroxy-4-(4''-methyl-biphenyl-4-sulfonyl)-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CSrc | CHEMBL425209 | Drug Info |
| Erbeta --- ER | (4-{4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl}-piperazin-1-yl)-(2-hydroxy-phenyl)-methanone | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3,8-dicarboxylic acid 3-hydroxyamide 8-methylamide | Drug Info |
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