Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HDAC1 --- HDAC2 | rac-N-(2-aminophenyl)-3-(4-(1-(2-morpholinoethylamino)-2-oxo-2-(4-(trifluoromethyl)phenylamino)ethyl)phenyl)acrylamide | Drug Info |
| Erbeta --- ER | 3-Chloro-4-((1R,2R,5R)-5-hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1,5-di-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxy]-3-oxapentane | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(5-((2-fluoro-4-(trifluoromethyl)benzamido)methyl)-2-methylphenoxy)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 2-Oxo-nonanedioic acid 1-methylamide 9-{[4-(5,6,7,8-tetrahydro-naphthalen-2-yl)-thiazol-2-yl]-amide} | Drug Info |
| Erbeta --- ER | 4-ethyl-2-(4-hydroxyphenyl)quinolin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-methyl-N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) | Drug Info |
| Erbeta --- ER | 3-(3-bromo-4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2,3,4,11-tetrahydro-1H-benzo[a]carbazole | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-o-tolyl-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| HER2 --- CD221 | 3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-6-yl)-1-((trans)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| Erbeta --- ER | SID124876662 | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-propan-1-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenylthio)-2-methylpropanoic acid | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(Naphthalen-2-yloxy)-ethoxy]-benzyl}-malonic acid monomethyl ester | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-propyl-2H-benzo[1,4]oxazin-7-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-(4-(4-fluorophenoxy)benzylcarbamoyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-phenylquinazolin-2-amine | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-6-(2-(piperidin-1-yl)ethoxy)-1H-indol-3-yl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-Ethoxy-3-[4-((E)-5-phenyl-pent-2-en-4-ynyloxy)-phenyl]-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-methoxyethyl)-3-(2-phenylacetamido)thiophene-2-carboxamide | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3-fluoro-4-methoxyphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{3-[(4-Adamantan-1-yl-benzoylamino)-methyl]-5-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
| JNK1 --- JNK3 | trans-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-4-methoxycyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-4-vinylquinolin-6-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-tert-butylphenyl)diphenylmethylthio)propanoic acid | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-((Piperidin-1-yl)methanone)phenyl)-5-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| JNK1 --- JNK3 | 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | (E)-3-[4-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-phenyl]-N,N-dimethyl-acrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-{[3'-fluoro-4'-(trifluoromethyl)-1,1'-biphenyl-4-yl]methyl}sulfamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(4-methoxybut-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-benzylpiperazin-1-yl)-3-chlorophenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | 6-(4-hydroxy-3-methoxyphenyl)naphthalen-1-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| PPAR gamma --- PPAR delta | 2-{1-[3-(4-Benzoyl-2-propyl-phenoxy)-propyl]-1H-indol-5-yloxy}-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | 2-(2-(naphthalen-1-yloxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | SID87348867 | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(tritylthio)propan-1-ol | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(oxazol-2-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 4-bromo-7-hydroxy-9a-propyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-morpholinopropyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-7-methoxy-benzofuran-4-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)cyclopentanecarboxamide | Drug Info |
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