Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (2S)-2-(2'-methyl-5-((pyridin-3-yloxy)methyl)biphenyl-2-ylcarboxamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP13 | 2-(4-Benzoyl-piperazine-1-sulfonyl)-N-hydroxy-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(S)-5-[3-(4-acetyl-piperazin-1-yl)-propyl]-3-(2,5-difluoro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (20S)-19,20,22,23-Tetrahydro-21-methyl-19-oxo-5H,21H-18,20-ethano-12,14-etheno-6,10-methenobenz[d]imidazo[4,3-l][l,6,9,13]oxatriazacyclononadecosine-9-carb onitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4'-(1H-imidazol-2-yl)-biphenyl-4-yl]-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-3-(3-dimethylamino-propyl)-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-(3,5-difluoro-benzyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide | Drug Info |
| Ftase --- FPTase | (3-Bromo-phenyl)-[1-(3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-methanone | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-2-((R)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2-chloro-10H-phenothiazin-10-yl)-3-(phenethylamino)propan-2-ol | Drug Info |
| Ftase --- FPTase | 17-methyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP3 | (R)-2-[3-(2-chloro-biphenyl-4-yl)-propyl]-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-cyanobenzamide | Drug Info |
| Ftase --- FPTase | (R)-8-chloro-11-(1-methanesulfonyl-piperidin-4-yl)-5-piperazin-1-yl-11H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| MMP2 --- MMP9 | 2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-methylcarbamoylmethyl-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N,5-dimethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-methyl-2-(methylsulfonamido)benzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-3,3-dimethylbutan-1-one | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-nonanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | ((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methanamine | Drug Info |
| Ftase --- FPTase | (S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-thiophen-2-ylmethyl-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Acetyl-piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N-ethyl-5-(3-hydroxypropyl)-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(4-Cyano-benzyl)-(3H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylamino]-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| Lck --- VEGFR | 6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-hydroxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(p-tolyloxy)phenyl)ethan-15-ylsulfonamido)propanamide | Drug Info |
| Src --- VEGFR | N-1,3-benzodioxol-4-yl-7-(3-pyrrolidin-1-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 2-(3-tert-Butyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-(4-oxo-2-(phenylimino)thizolidin-5-yl)acetyl)-)-1,4-diazepan-1-yl)pyrimidine-2,4,6-(1H,3H,5H)-trione | Drug Info |
| VEGFR1 --- TEK | (E/Z)-6-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-4-amine | Drug Info |
| Ftase --- FPTase | (E)-4-(4-benzoylbenzyloxy)-3-methylbut-2-enyl diphosphate | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2,6-dichloro-5-fluoronicotinoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CD135 | (Z)-1-Naphthalen-2-yl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]urea | Drug Info |
| Ftase --- FPTase | 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-4-carboxylic acid pyridin-4-ylamide | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)-N-methylbenzenesulfonamide | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-(6-Chloropyridine-3-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CDK1 | 3-{5-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-3-ylamino}-propan-1-ol | Drug Info |
| Ftase --- FPTase | 4-{5-[((S)-1-Benzyl-2-oxo-azepan-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-2-(4-fluorophenylamino)-N-hydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- Ckit | N3-(2-acetamidopyrimidin-5-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(naphthalen-1-yloxy)-benzonitrile | Drug Info |
| MMP3 --- MMP8 | [7-Amino-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
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