Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK1 --- AuroraA | N-(5-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)pyridin-2-yl)-N-(2-morpholinoethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(2-(1-chloro-7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- CDK4 | (4Z)-6-(3-Furyl)-4-({[5-(4-methylpiperazin-1-yl)pyrazin-2-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK1 --- GSK3 | 8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carboximidic acid butyl ester | Drug Info |
| CDK1 --- GSK3 | 6-(4-Chloro-phenyl)-7-methyl-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(thiophen-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-{[2-(methylamino)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(Benzo[d]1,3-dioxolylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- CDK1 | 8-[(4-Methanesulfonyl-phenylamino)-methylene]-6,8-dihydro-thiazolo[5,4-e]indol-7-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(5-(methylsulfonyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(5-{3-[3-(2-Fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-2H-pyrazol-3-ylamino)-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2-(7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 8-[1-(4-methanesulfonylmethyl-phenylamino)-meth-(Z)-ylidene]-6,8-dihydro-thiazolo[5,4-e]indol-7-one | Drug Info |
| CDK2 --- CDK1 | GW335962X | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(dimethylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK4 | 4-[(3-Hydroxy-4-methoxy-benzylamino)-methylene]-6-methoxy-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | 4-(4-(2-amino-4-methylthiazol-5-yl)pyrimidin-2-ylamino)phenol | Drug Info |
| CDK2 --- CDK4 | CHEMBL457888 | Drug Info |
| CDK2 --- CDK4 | 8-Cyclopentyl-6-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- Cyclin E | 3-{[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-pyridin-3-ylmethyl-amino}-2-methyl-propionitrile | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-((5-(furan-3-yl)thiophen-2-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 2-(5-((2-acetamidothiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(5-methylthiophen-2-yl)benzyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | [6-(4-Amino-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-tert-butyl-amine | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(4-Butyl-benzylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- GSK3 | (Z)-4-(5-(1-(2-imino-4-oxothiazolidin-5-ylidene)ethyl)furan-2-yl)benzenesulfonamide | Drug Info |
| CAII --- CAI | 1-(3-(3-bromophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| CDK4 --- Cyclin E | 5-{5-[3-(4-Methyl-piperazin-1-yl)-ureido]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-thiophene-2-carboxylic acid ethyl ester | Drug Info |
| CAII --- CAI | (2-{[(2-Iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| Ckit --- BRaf | 2-((2-(3-(1H-imidazol-1-yl)propylamino)pyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| CAII --- CAI | 3-Mercapto-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| Cmet --- Ckit | N-(1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide | Drug Info |
| CAII --- CAI | Trans-1(R)S,2S(R)-2-(2,3-dibromo-4,5-dimethoxybenzyl)cyclohexyl 3,5-dinitrobenzoate | Drug Info |
| COX2 --- 5LOX | 1-(7-tert-Butyl-2,3-dihydro-benzofuran-5-yl)-hex-5-yn-1-one | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-(4-sulfamoyl-benzyloxycarbonylmethyl)-pyridinium; perchlorate | Drug Info |
| COX2 --- 5LOX | 2,6-Diethyl-4-[2-(4-methoxy-phenyl)-vinyl]-phenol | Drug Info |
| CAII --- CAI | N-(2,3-Dichloro-4,6-disulfamoyl-phenyl)-2,3,4,5,6-pentafluoro-benzamide | Drug Info |
| CSrc --- CABL | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{5-[(4-phenylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | N-(5-(4-methoxybenzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | [2-({[2-(4-Sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethylamino]-acetic acid | Drug Info |
| CSrc --- CABL | N-benzyl-1-(2-chloro-2-(4-chlorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-succinamic acid | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-propyl-6-(propylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | ((2-Hydroxy-phenyl)-{2-[(2-hydroxy-phenyl)-(2-sulfamoyl-benzothiazol-6-yloxycarbonylmethyl)-amino]-ethyl}-amino)-acetic acid | Drug Info |
| CSrc --- CABL | 4-(2,4-Dichloro-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| CSrc --- CD221 | N'-(4-tert-Butylbenzoyl)-2-(1H-indol-3-yl)-2-oxoacetohydrazide | Drug Info |
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