Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | (S)-N-(1-(2-(5-fluoroindolin-1-yl)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | (S)-3,3-dimethyl-1-(5-phenyl-1,3,4-oxadiazol-2-yl)butan-2-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((S)-2-(4-tert-butoxyphenyl)-1-cyanoethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(S)-1-formyl-2-(1H-indol-2-yl)-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(3-trifluoromethyl-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | CCK7 analogue | Drug Info |
| CCKBR --- CCKAR | (S)-3-{(S)-2-[(R)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-methyl-N-phenethyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-({1-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | CHEMBL1172428 | Drug Info |
| CCKBR --- CCKAR | 1-[(R)-1-(4-Benzoyl-piperidine-1-carbonyl)-4-oxo-4-pyrrolidin-1-yl-butyl]-3-m-tolyl-urea | Drug Info |
| CCKBR --- CCKAR | Quinoline-3-carboxylic acid [1-(benzyl-methyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(3,4-dihydroxy-phenyl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate.AcOH | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[2-((S)-3,3-dimethyl-butyrylamino)-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-nitro-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CD135 --- MCSF | LESTAURTINIB | Drug Info |
| CD221 --- TEK | 2-[2-(Decahydro-naphthalen-1-ylmethyl)-4-hydroxy-3,6-dioxo-cyclohexa-1,4-dienylamino]-3-hydroxy-butyric acid | Drug Info |
| CDK1 --- CDK2 | (Z)-4-((6-(hydroxymethyl)-2-oxoindolin-3-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N-methyl-benzenesulfonamide | Drug Info |
| CDK1 --- GSK3 | 3-Methoxy-9-trifluormethyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one | Drug Info |
| CDK1 --- GSK3 | Paullone 2 | Drug Info |
| CDK1 --- GSK3 | 2-(3-Hydroxy-prop-1-ynyl)-9-trifluoromethyl-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(isoquinolin-6-yl)-1,3,4-oxadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1,4,4-Trimethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | SID124349855 | Drug Info |
| CDK2 --- CDK1 | GW280670X | Drug Info |
| CDK2 --- CDK1 | 2-Amino-5-({3-[(4-chlorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl}-methyl)-1,3-thiazol-4-ol | Drug Info |
| CDK2 --- CDK1 | 4-(2-(1-chloro-7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic Acid(4-Fluoro-phenyl)-amide | Drug Info |
| CDK2 --- CDK1 | 6-Cyclohexylmethoxy-N*2*-(4-methylsulfanyl-phenyl)-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK4 | [4-(6-Methyl-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL433068 | Drug Info |
| CDK2 --- CDK4 | 3-((2,5-Dichloro-phenyl)-{2-[4-(3-dimethylamino-2-hydroxy-propoxy)-phenylamino]-pyrimidin-4-yl}-amino)-propionitrile | Drug Info |
| CDK2 --- CDK4 | 1-{4-[4-(2-Chloro-phenylamino)-pyrimidin-2-ylamino]-phenoxy}-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- Cyclin E | 2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol | Drug Info |
| CDK2 --- Cyclin E | 1-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-piperidin-4-ol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-(pyridin-2-yl)thiophen-2-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-((S)-3-hydroxy-but-1-ynyl)-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(Biphenyl-4-ylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N-(4-Fluorobenzyl)-2-(trifluoromethyl)quinazolin-4-amine | Drug Info |
| CDK2 --- Cyclin E | 7-fluoro-5-(2-fluorophenyl)-3-methyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- GSK3 | N-(5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | Ethyl-2-((3-(4-benzoyl-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)diazenyl)-3-oxo-3-phenylpropanoate | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Amino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | N-[2-({2-[(aminosulfonyl)amino]ethyl}dithio)ethyl]sulfamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(3-methoxypropyl)picolinamide | Drug Info |
| CAII --- CAI | 4,6-Dinitro salicylic acid | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(diethylamino)ethyl)picolinamide | Drug Info |
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