Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- Cyclin E | (4-Butylsulfanyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-phenyl-methanone | Drug Info |
| CDK2 --- Cyclin E | (3-Isopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-urea | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-methoxy-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N6-(2,3'-bithiophen-5-ylmethyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- GSK3 | 4-[5-(4-Amino-cyclohexylamino)-3-chloro-pyrazolo[1,5-a]pyrimidin-7-ylamino]-N,N-dimethyl-benzenesulfonamide | Drug Info |
| CAII --- CAI | 1-(3-(2-bromophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Methylamino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid [4-(3-sulfamoyl-phenylsulfamoyl)-phenyl]-amide | Drug Info |
| Ckit --- BRaf | 4-((4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)-1-methyl-1H-pyrazol-5-ylamino)methyl)-N-methylpicolinamide | Drug Info |
| CAII --- CAI | 3-Pentafluorobenzenesulfonylamino-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| COX2 --- 5LOX | 2-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-4-(4-fluoro-phenyl)-oxazole-5-sulfonic acid amide | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[4-(4-sulfamoyl-phenylamino)-pyrimidin-2-yl]-acetamide | Drug Info |
| COX2 --- 5LOX | 3-(4-Isopropylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | 3-(4-Methoxyphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | Diethyl 2-(2-(3-(4-(ethoxycarbonyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate | Drug Info |
| CSrc --- CABL | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-[18F]fluoroethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Drug Info |
| CAII --- CAI | 3-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-dimethylamino-1-methyl-ethyl ester | Drug Info |
| CSrc --- CABL | N-(3-bromophenyl)-1-(2-chloro-2-(4-fluorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-(4-(4-fluoro-3-methylphenyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide | Drug Info |
| CSrc --- CABL | (E)-3-(2-(6-(cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| CAII --- CAI | [Carboxymethyl-(2-{carboxymethyl-[2-(carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CSrc --- CABL | N-Benzyl-1-(2-chloro-2-phenylethyl)-6-(methylsulfonyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (sulfamoylamino)benzene | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(2-methoxyethoxy)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 2-Amino-N-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-acetamide | Drug Info |
| CSrc --- CDK4 | Granulatimide | Drug Info |
| CAII --- CAI | N-(2-chloro-4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 1-naphthalene boronic acid | Drug Info |
| DHFR --- TYMS | N-[4-[(2,4-Diamino-5-propyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl]-L-glutamic Acid | Drug Info |
| CAII --- CAI | 1-[(2,4-Disulfamoyl-5-trifluoromethyl-phenylcarbamoyl)-methyl]-2,4,6-trimethyl-pyridinium; perchlorate | Drug Info |
| EGFR --- HER2 | (E)-2-Cyano-3-(3,4-dihydroxy-phenyl)-N-(2,6-dimethyl-phenyl)-acrylamide | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid 2-(4-sulfamoyl-phenyl)-ethyl ester | Drug Info |
| EGFR3 --- Beta PDGFR | SID855715 | Drug Info |
| CAII --- CAI | 3-[({4-[(aminocarbonyl)amino]phenyl}sulfonyl)amino]benzenesulfonamide | Drug Info |
| EGFR3 --- CSrc | {2-[3-(Furan-2-carbonyl)-1-methyl-1H-indol-2-yldisulfanyl]-1-methyl-1H-indol-3-yl}-furan-2-yl-methanone | Drug Info |
| CAII --- CAI | 2,6-Dimethyl-4-phenyl-1-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-pyridinium; perchlorate | Drug Info |
| EGFR3 --- HER2 | 3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-phenyl)-2-(3,4-dihydroxy-benzoyl)-acrylonitrile | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-iodo-4-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(pyridin-2-yloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| CAII --- CAI | 6-(2-Hydroxy-ethoxy)-benzothiazole-2-sulfonic acid (2-amino-acetyl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2-methoxy-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| CAII --- CAI | SID528890 | Drug Info |
| EGFR3 --- HER2 | (R)-7-(4-(1-(4-Chlorophenyl)ethylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-fluoro-4-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-(3-chloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 6-Nitrooxy-hexanoic acid ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(3-cyano-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| CAII --- CAI | N-2-naphthylsulfamide | Drug Info |
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