Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | Drug Info |
| CDK2 --- CDK4 | 4-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)benzoic acid | Drug Info |
| CDK2 --- CDK4 | [4-(5-Bromo-2,4-dimethyl-1H-pyrrol-3-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | N,4-dimethyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine | Drug Info |
| CDK2 --- CDK4 | (3,4-Dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-4-(3-methylamino-prop-1-ynyl)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-(4-hydroxy-piperidin-4-ylethynyl)-3-[1-(3-methoxy-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one; hydrochloride | Drug Info |
| CDK2 --- Cyclin E | trans-4-(6-(biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)cyclohexanol | Drug Info |
| CDK2 --- Cyclin E | (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-p-tolyl-methanone | Drug Info |
| CDK2 --- Cyclin E | N-[5-(4,4-Dimethyl-2-oxo-pentylsulfanyl)-thiazol-2-yl]-acetamide | Drug Info |
| CDK2 --- Cyclin E | N-(4-Oxo-3-pyridin-3-yl-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-cyclohexanol | Drug Info |
| CDK2 --- GSK3 | N-(5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(4-ethylpiperazin-1-yl)butanamide | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid | Drug Info |
| CDK2 --- JNK1 | N-(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-2-oxoethyl)acetamide | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-[4-(3-sulfamoyl-phenylsulfamoyl)-phenyl]-acetamide | Drug Info |
| Chk --- Met | CHEMBL1197465 | Drug Info |
| CAII --- CAI | 4-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-3-iodo-benzenesulfonamide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(3-hydroxypropylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 2-propylcyclohexanol | Drug Info |
| COX2 --- 5LOX | 2-Methoxy-6-methyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | [3-(4-Sulfamoyl-phenyl)-thioureido]-acetic acid | Drug Info |
| COX2 --- 5LOX | 2,6-Dimethyl-4-(2-thiophen-2-yl-ethyl)-phenol | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-(3-sulfamoyl-phenyl)-benzamide | Drug Info |
| COX2 --- HRH1 | 3-{11-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepin-2-yl}-propionic acid | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-(2-sulfamoyl-benzothiazol-6-yl)-acetamide | Drug Info |
| CSrc --- CABL | N-(5-(4-fluorobenzylthio)-1,3,4-thiadiazol-2-yl)-4-chlorobenzamide | Drug Info |
| CAII --- CAI | [(S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-4-methyl-pentanoylamino]-acetic acid | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N,N-diethyl-6-(propylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | Trans-1(R)S,2S(R)-2-(3-bromo-4,5-dimethoxybenzyl)cyclohexanol | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-(2-fluorobenzyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (1R,2R,5R)-4-((1R,5S,8S,10R,11S,12S)-3,12-Dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethyl]-amide | Drug Info |
| CSrc --- CABL | (S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-((R)-1-carbamoyl-3-cyclohexyl-propylcarbamoyl)-butyric acid | Drug Info |
| CAII --- CAI | (R)-4-((3R,5S,7R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (4-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- CABL | N-(3-bromobenzyl)-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | sodium 3-aminobenzoate | Drug Info |
| CSrc --- FGFR1 | 1-Phenyl-1H-benzoimidazole-4,5-diol | Drug Info |
| CAII --- CAI | 2,3,5,6-Tetrafluoro-N-(2-fluoro-4-sulfamoyl-phenyl)-benzenesulfonamide | Drug Info |
| DHFR --- TYMS | (S)-2-{4-[2-(2-Amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | 3-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-(2-dimethylamino-ethoxy)-ethyl ester | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | {[(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR --- PDGFR | 2-(3,4-dihydroxybenzoyl)-3-(1H-indol-3-yl)acrylonitrile | Drug Info |
| CAII --- CAI | 5-(4-Pentafluorobenzenesulfonylamino-benzenesulfonylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| EGFR3 --- CSrc | 1-Methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-4-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide | Drug Info |
| CAII --- CAI | N-[4-(aminosulfonyl)phenyl]-4-nitrobenzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methylpyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-{[4-(4-sulfamoyl-phenylsulfamoyl)-phenylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
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