Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK4 | CHEMBL99948 | Drug Info |
| CDK2 --- CDK4 | CHEMBL322019 | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-phenylpyridin-2-yl)methyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | 2-(4-(aminomethyl)piperidin-1-yl)-N-(biphenyl-4-ylmethyl)-9-isopropyl-9H-purin-6-amine | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-[(R)-4-hydroxy-3-((R)-methylamino)-pent-1-ynyl]-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | N-[3-[5-Fluoro-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-4-yl]-1-((R)-1-hydroxy-ethyl)-prop-2-ynyl]-methanesulfonamide | Drug Info |
| CDK2 --- Cyclin E | N-[3-(4-methoxyphenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]hydrazine-1,2-dicarboxamide | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-(4-(5-chlorothiophen-2-yl)benzyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | 2-[(2-Hydroxy-ethyl)-(9-isopropyl-6-phenylamino-9H-purin-2-yl)-amino]-ethanol | Drug Info |
| CDK2 --- GSK3 | GW810372X | Drug Info |
| CDK2 --- JNK1 | 4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-(4-methylpiperidin-1-yl)piperidine-1-carboxamide | Drug Info |
| CAII --- CAI | 2,4,6-trimethyl-1-(3-phenyl-5-sulfamoyl-1H-indole-2-carboxamido)pyridinium perchlorate | Drug Info |
| Chk --- Met | CHEMBL1197529 | Drug Info |
| CAII --- CAI | {Carboxymethyl-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| Ckit --- BRaf | 2-(pyridin-4-ylmethylamino)-N-(2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-bromo-4-sulfamoyl-phenyl)-amide | Drug Info |
| COX2 --- 5LOX | 1-(4-Bromo-phenyl)-5-nitro-1lambda(4)-benzo[1,3,2]dithiazole 3,3-dioxide | Drug Info |
| CAII --- CAI | 4-[(Heptadecafluorooctane-1-sulfonylamino)-methyl]-benzenesulfonamide | Drug Info |
| COX2 --- 5LOX | 1-(7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-2-cyclopropyl-ethanone | Drug Info |
| CAII --- CAI | 4-((5S,6S,7S,8R,11S,15R,17S)-3,7-Dihydroxy-10-methyl-13-(R)-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2,3-dichloro-4,6-disulfamoyl-phenyl)-amide | Drug Info |
| COX2 --- HRH1 | 11-{2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-ethylsulfanyl}-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | SID526207 | Drug Info |
| CSrc --- CABL | 4-(3-(benzyloxy)benzylidene)-1-(3,4-dichlorophenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | 2,6-Diethyl-4-phenyl-1-(4-sulfamoyl-benzyloxycarbonylmethyl)-pyridinium; perchlorate | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-(4-fluorophenyl)ethyl)-N-(2-fluorobenzyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | piperidine-1-sulfonamide | Drug Info |
| CSrc --- CABL | 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine | Drug Info |
| CAII --- CAI | (S)-3-Phenyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid methylcarbamoylmethyl with resin | Drug Info |
| CSrc --- CABL | 1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-2-ylmethyl)-1Hpyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone | Drug Info |
| CSrc --- FGFR1 | 3-(4-Chloro-phenyl)-1-oxo-1H-indene-2-carboxylic acid amide | Drug Info |
| CAII --- CAI | (2S,3R)-3-Methyl-2-(4-sulfamoyl-benzoylamino)-pentanoic acid | Drug Info |
| DHFR --- TYMS | 4-{4-[4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-4-carboxy-butyrylamino}-4-carboxy-butyric acid anion | Drug Info |
| CAII --- CAI | N,N-dialkylthio-carbonylsulfenylamino derivative | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | SID144209571 | Drug Info |
| EGFR --- PDGFR | 6-(2,6-dichlorophenyl)-2-(dimethylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | Drug Info |
| CAII --- CAI | biphenyl-4-ylboronic acid | Drug Info |
| EGFR3 --- CSrc | ({2-[3-(Carboxymethyl-carbamoyl)-1-methyl-1H-indol-2-yldisulfanyl]-1-methyl-1H-indole-3-carbonyl}-amino)-acetic acid | Drug Info |
| CAII --- CAI | Ethyl1-(3-((4-hydroxyphenyl)diazenyl)phenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazole-4-carboxylate | Drug Info |
| EGFR3 --- HER2 | (S)-N-(2-hydroxyethyl)-N-methyl-2-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-5-yloxy)propanamide | Drug Info |
| CAII --- CAI | 3-Bromo-4-(heptadecafluorooctane-1-sulfonylamino)-benzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | 3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4,5-dihydroxy-phenyl]-2-cyano-acrylamide | Drug Info |
| CAII --- CAI | SID526204 | Drug Info |
| EGFR3 --- HER2 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-[piperidin-1-yliminomethyl]-pyrimidine-4,6-diamine | Drug Info |
| CAII --- CAI | 2-Amino-N-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-acetamide | Drug Info |
| EGFR3 --- HER2 | 4-(3'-bromoanilino)-6,7-dimethoxyquinazoline hydrochloride | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-{[4-(3-sulfamoyl-phenylsulfamoyl)-phenylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
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