Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK4 | [4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-[5-((R)-3-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | 1-(4-Methoxy-phenyl)-3-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-urea | Drug Info |
| CDK2 --- Cyclin E | 2-{(2-Hydroxy-ethyl)-[6-(4-methoxy-benzylamino)-9-naphthalen-2-ylmethyl-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | N6-(2,2'-bithiophen-5-ylmethyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 7-chloro-5-(2-fluorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | 6-(4-Dimethylamino-benzyl)-3-ethyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-3-isopropyl-7-nitro-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | 2-Amino-1-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-ethanol | Drug Info |
| CDK2 --- GSK3 | [4-(6-Methyl-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(4-trifluoromethyl-phenyl)-amine | Drug Info |
| CAII --- CAI | sodium 4-fluorobenzoate | Drug Info |
| CDK2 --- JNK1 | 4-(5-chloro-4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide | Drug Info |
| CAII --- CAI | (S)-2-[3-(4-Chloro-3-sulfamoyl-benzoylamino)-propionylamino]-3-(3H-imidazol-4-yl)-propionic acid | Drug Info |
| Chk --- Met | CHEMBL1197320 | Drug Info |
| CAII --- CAI | 2-ethyl-N-(4-sulfamoylphenyl)hexanamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-hydroxyethyl)picolinamide | Drug Info |
| CAII --- CAI | 3-Hydroxy-2-[3-(4-sulfamoyl-phenyl)-thioureido]-butyric acid | Drug Info |
| COX2 --- 5LOX | 4-[2-(4-Fluoro-phenyl)-hex-1-enyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | 2-ethyl-N-hydroxyhexanamide | Drug Info |
| COX2 --- 5LOX | 2,6-Diethyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | Phosphoric acid ethyl ester methyl ester 4-nitro-phenyl ester | Drug Info |
| COX2 --- HRH1 | 11-[2-(4-Benzyl-piperazin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(1H-imidazol-1-yl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 2-{3-(1H-Imidazol-4-yl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionylamino}-3-phenyl-propionic acid | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-6-(methylthio)-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-{[(morpholin-4-ylcarbonothioyl)thio]amino}benzenesulfonamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N,N-diethyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | {(2-{2-[2-(Bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethyl)-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile | Drug Info |
| CAII --- CAI | 4-[2-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-ethyl]-benzenesulfonamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-(2-chlorophenethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-(2-Hydroxy-ethyl)-N-[2-(N-methyl-guanidino)-acetyl]-benzenesulfonamide | Drug Info |
| CSrc --- FGFR1 | 3-(2,6-Dichloro-phenyl)-[1,6]naphthyridine-2,7-diamine | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(4-sulfamoyl-phenyl)-ethyl ester | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-(2-iodo-4-sulfamoyl-phenyl)-benzenesulfonamide | Drug Info |
| DHFR --- TYMS | CHEMBL422395 | Drug Info |
| CAII --- CAI | 2,2-Dimethyl-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| EGFR --- PDGFR | (E)-2-Cyano-3-(1H-indol-3-yl)-thioacrylamide | Drug Info |
| CAII --- CAI | N,N-dialkylthio-carbonylsulfenylamino derivative | Drug Info |
| EGFR3 --- CSrc | 3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(2-Methyl-quinolin-5-yloxy)-ethyl]-piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | 2-((4-(1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine | Drug Info |
| 5HT1a --- SERT | (S)-1-[(1R,3S,5S)-3-(4-Methoxy-benzo[b]thiophen-2-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | 2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [4-(2-fluoro-ethoxy)-3-(4-methyl-piperazin-1-yl)-phenyl]-amide | Drug Info |
| A3AR --- ADRA1A | 4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid 6-chloro-benzo[1,3]dioxol-5-ylmethyl ester | Drug Info |
| ADRA1A --- HRH1 | (5,11-Difluoro-2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine | Drug Info |
| ADRA1A --- HRH1 | Amoxapine | Drug Info |
| ADRA1A --- HRH1 | 4-[(3-Chlorophenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone | Drug Info |
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