Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-2-methylnicotinamide | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-6-Methyl-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4R)-4-(5-Chloro-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-4-(6-methoxybenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-((1-(2-(8-chloro-2-methylquinolin-5-yloxy)ethyl)piperidin-4-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | Drug Info |
| 5HT1b --- SERT | (1R)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide | Drug Info |
| ABL --- FGFR | 3-(4-(1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-1,2,3-triazol-1-yl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| ADRA1A --- HRH1 | SID104171359 | Drug Info |
| ADRA1A --- HRH1 | 2-Ethyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene | Drug Info |
| ADRA1A --- HRH1 | 2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione | Drug Info |
| CABL --- Ckit | PHA-739358 | Drug Info |
| CABL --- STK1 | Dasatinib | Drug Info |
| Aurora --- GSK | 4-(3-Adamantan-1-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)-benzoic acid | Drug Info |
| AuroraA --- CD135 | N1-[3-(5-[6-(4-Hydroxypiperidino)-2-methyl-4-pyrimidinyl]amino-1H-3-pyrazolyl)phenyl]-1-benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | 3-fluoro-N-({2-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}methyl)-benzamide | Drug Info |
| AuroraA --- STK1 | 5-(pyridin-4-yl)-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole | Drug Info |
| AuroraA --- STK1 | K00001 | Drug Info |
| AuroraA --- STK1 | N2-(4-(benzo[d]thiazol-2-yl)-3-methoxyphenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | Drug Info |
| AuroraA --- STK1 | N-Cyclopropyl-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide | Drug Info |
| AuroraA --- STK1 | N-Ethyl-N'-[4-(1-ethyl-4-{2-[4-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-3-yl)phenyl]urea | Drug Info |
| AuroraA --- STK1 | 1-(3-chloro-4-fluorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| AuroraA --- STK1 | CHEMBL381724 | Drug Info |
| CDK1 --- Cyclin E | PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid pyridin-4-ylamide | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Imino-4-methyl-5-pentyl-pyrrolidin-3-ol | Drug Info |
| BNOS --- Hepatocyte NOS | (R,E)-3-propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Methyl-isothiourea | Drug Info |
| BNOS --- Hepatocyte NOS | 2-(2-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)pyrrolidin-1-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylethanamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((isobutyl(piperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 2,7-dinitro-2H-indazole | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(2-Bromo-phenyl)-2-ethyl-isothiourea | Drug Info |
| BNOS --- Hepatocyte NOS | 6-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-naphthalen-1-yl}-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(3,3-Difluorocyclobutyl)-1H-imidazo[4,5-b]pyrazin-1-yl)-methyl)-8-fluoroquinolin-2(1H)-one | Drug Info |
| CABL --- PKCA | N-(3-chlorophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-methoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(5-Fluoro-3-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-1-phenyl-propan-1-one oxime | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- CD243 | Isoconazole | Drug Info |
| ADRA1A --- HRH1 | N-((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)-4-fluorobenzamide | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{1-[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]hexahydro-1H-azepin-4-yl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide | Drug Info |
| CABL --- FGFR1 | PD-0166326 | Drug Info |
| CAI --- CAIX | 4-(Carbamolymethylthio)pyridine-3-sulfonamide | Drug Info |
| Aurora --- VEGFR | 4-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline | Drug Info |
| AuroraA --- CDK4 | 7-cyclohexyl-N-4-morpholinophenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-(6-methyl-3-styryl-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-ethyl-4-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)piperazine-1-carboxamide | Drug Info |
| AuroraA --- STK1 | 1-cyclohexyl-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| AuroraA --- STK1 | N-[3-(dimethylamino)phenyl]-2-{2-[(7-{3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide | Drug Info |
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