Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| AuroraA --- STK1 | 6-methoxy-N-(5-methyl-1,3-thiazol-2-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| CDK1 --- Cyclin E | AZD-5438 | Drug Info |
| Beta PDGFR --- Ckit | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(furan-2-ylmethyl)propane-1,3-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((methyl(pyrrolidin-3-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((4-chlorobenzyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(2-Chloro-phenyl)-2-ethyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | ethyl 2-((3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)(3-(benzo[d][1,3]dioxol-5-ylmethylamino)propyl)amino)acetate | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-(((cyclopropylmethyl)(piperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | N-{2-[1-(4-methoxy-benzyl)-piperidin-4-ylamino]-benzothiazol-6-yl}-thiophene-2-carboxamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-ethyl-pyrrolidin-2-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamidine | Drug Info |
| CAI --- CAIX | 5,6-dihydro-2H-pyran-2-one | Drug Info |
| 5HT1a --- SERT | 1-phenyl-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-1-one | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-trifluoromethyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-nitrophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5LOX --- HRH1 | [3-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-furan-2-yl)-1-methyl-prop-2-ynyl]-N-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Fluorophenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | SID56463056 | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{1-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]hexahydro-1H-azepin-4-yl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 2-Ethyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-benzo[f]azulene | Drug Info |
| CABL --- FGFR1 | PHA-739358 | Drug Info |
| CAI --- CAIX | 4-Amino-3-iodo-benzenesulfonamide | Drug Info |
| Aurora --- VEGFR | N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-(7-(3-hydroxyphenylamino)pyrazolo[1,5-a]pyrimidin-2-yl)benzamide | Drug Info |
| AuroraA --- STK1 | CHEMBL381721 | Drug Info |
| AuroraA --- STK1 | (S)-(4-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)morpholin-3-yl)methanol | Drug Info |
| AuroraA --- STK1 | 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | CHEMBL215495 | Drug Info |
| AuroraA --- STK1 | 2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-indazol-5-yl)acetamide | Drug Info |
| AuroraA --- STK1 | 2-(5-Methyl-1H-pyrazol-3-yl)-1H-indole | Drug Info |
| AuroraA --- STK1 | 2-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-N-(3-(trifluoromethyl)phenyl)acetamide | Drug Info |
| B-Raf --- MEK | 3-benzyl-4-methyl-2-oxo-2H-chromen-7-yl cyclopropanecarboxylate | Drug Info |
| Beta PDGFR --- CABL | N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)piperidine-1-carboxamide | Drug Info |
| Beta PDGFR --- FGFR1 | (Z)-4-(4-((2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde | Drug Info |
| BNOS --- Hepatocyte NOS | 5-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carbonyl)picolinonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | (4'-amino-5'-fluoro-1'H-spiro[piperidine-4,2'-quinazoline]-1-yl)(4-(aminomethyl)phenyl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | 7-(3,4-dimethoxyphenyl)-6-methylquinazoline-2,4-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(1-Aza-bicyclo[2.2.2]oct-2-ylmethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(Cyclobutylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(6-(dimethylamino)pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-8-fluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Chloro-3-morpholin-4-ylmethyl-3H-benzooxazol-2-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-6-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| CAI --- CAIX | 1-(4'-Aminophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide | Drug Info |
| 5HT1a --- SERT | [3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin-5-yloxy)-ethyl]-amine | Drug Info |
| 5HT1a --- SERT | 1-(biphenyl-4-yl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-one | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-fluorophenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
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