Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- AuroraA | (S)-4-{2-(2-Ethylphenylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- AuroraA | 8-[(4-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | GW396574X | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 1-(3-(2-aminopyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidin-3-ol | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid amide | Drug Info |
| CDK2 --- CDK1 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-benzoic acid | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-isopropylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | N-[(E)-amino(imino)methyl]-4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 6-Acetyl-2-{5-[bis-(2-methoxy-ethyl)-amino]-pyridin-2-ylamino}-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- CDK4 | 1-[4-(5-Bromo-4-phenylamino-pyrimidin-2-ylamino)-phenoxy]-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- CDK4 | (4Z)-{[(5-Furan-3-yl-4-hydroxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | 6-Bromo-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- Cyclin E | (2-Chloro-9-methyl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-N6-((4'-chlorobiphenyl-4-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-[6-(4-methoxy-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | (R)-2-(6-(Biphenyl-4-ylmethylamino)-9-propyl-9H-purin-2-ylamino)butan-1-ol | Drug Info |
| CDK2 --- Cyclin E | N6-((6-(1H-pyrazol-1-yl)pyridin-3-yl)methyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-Aminocyclohexyl)-9-cyclopentyl-N6-(biphenyl-4-ylmethyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | 5-Hydroxy-3-(4-methoxy-phenyl)-2H-indeno[1,2-c]pyrazol-4-one | Drug Info |
| CDK2 --- GSK3 | N-(6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 5-chloro-2-hydroxybenzoic acid | Drug Info |
| CDK4 --- Cyclin E | 1-[3-(2,5-Dimethyl-thiophen-3-yl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-(4-methyl-piperazin-1-yl)-urea | Drug Info |
| CAII --- CAI | sodium 4-(dimethylamino)benzoate | Drug Info |
| Ckit --- BRaf | 1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-benzylurea | Drug Info |
| CAII --- CAI | 4-(2-(pyridin-4-ylmethyleneamino)ethyl)benzenesulfonamide | Drug Info |
| COX --- PDE | kuraridin | Drug Info |
| CAII --- CAI | 4-(2-{[({[(3,4-dichlorophenyl)amino]carbonyl}amino)carbonothioyl]amino}ethyl)benzenesulfonamide | Drug Info |
| COX2 --- 5LOX | 1-(3,4-dichlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 3-(Nonafluorobutane-1-sulfonylamino)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| COX2 --- 5LOX | 3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-1-(4-fluorophenyl)-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-acetamide | Drug Info |
| CSrc --- CABL | N-(5-(4-methoxybenzylthio)-1,3,4-thiadiazol-2-yl)-4-chlorobenzamide | Drug Info |
| CAII --- CAI | 1-(3-Aminophenyl)-4-benzoyl-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazole-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| CSrc --- CABL | N-benzyl-1-(2-chloro-2-phenylethyl)-6-(propylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2-ethylhexanamide | Drug Info |
| CSrc --- CABL | N4-benzyl-1-(2-chloro-2-phenylethyl)-N6,N6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid | Drug Info |
| CSrc --- CABL | N-(5-(4-bromobenzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | N-(2-bromo-4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide | Drug Info |
| CSrc --- CABL | (E)-3-(2-(Purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| CAII --- CAI | 4-isothiocyanatobenzenesulfonamide | Drug Info |
| CSrc --- Ckit | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-phenylpyridin-2(1H)-one | Drug Info |
| CAII --- CAI | 2-Amino-N-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-acetamide | Drug Info |
| DHFR --- TYMS | 4-(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyric acid anion | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| DHFR --- TYMS | 2-[4-(2-Amino-6-methyl-4-oxo-4,4a,7,7a-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylsulfanyl)-benzoylamino]-pentanedioic acid | Drug Info |
| CAII --- CAI | SID527148 | Drug Info |
| EGFR --- HER2 | N-(2-chlorophenyl)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | Drug Info |
| CAII --- CAI | [(2-Hydroxy-phenyl)-(2-{(2-hydroxy-phenyl)-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
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