Target Information

Target General Infomation
Target ID
T02134
Former ID
TTDR00615
Target Name
Glutamate--cysteine ligase regulatorysubunit
Gene Name
gamma-GCS
Synonyms
GCS; GCS light chain; Gamma-ECS; Gamma-GCS; Gamma-glutamylcysteine synthetase; Glutamate cysteine ligase; Glutamate--cysteine ligase; Glutamate--cysteine ligase modifier subunit; gamma-GCS
Target Type
Research
Disease Cancer; Malaria [ICD9:140-229; ICD10: C00-C96, B54]
BioChemical Class
Carbon-nitrogen ligase
UniProt ID
Q9UB86
EC Number
EC 6.3.2.2
Sequence
MGFLKIGTPLSWDDVQDVKSLIRLYGILQFVHVXKLNKDRYDENIMFGDEIEYIIIRNDE
SLKESSALLCASDLIDEMMNLESVIDCQYGSHWTPEYSSFTIEGTPSVPFKLDINSSCFV
EDCMRIRRSKLNNVLSAVQGARAITLPCFPNVLLNNSVLMARRITGHESTKKKFDSKGKV
EFIENAKIKEKVHNSNNNIHKIINNKNNESKIVNNAFDQNKISSIEMVSYEMDENKSTNF
VNSDTVFAKNDEEGEVEEEDENENEQQQQQQQYQSNLQQQNVQPKQRQQMIQYVYDDEIE
NKNKEKDNTPRSCNDYNNVNDRTNTQDIFISSLKKTDSLFECEVFKPEQTNKYSKSALIT
DMTISPHARYVTNSQNIRKRRGTKIVSFNPIYKDINTEKMDHWKMSLDCNDKRLFKKVKK
KLTLDEHLIWNKSMTNKKIIDRKNNNPRDEVLNTSNFTLAMTNKEENNNENSLMDRVLKN
SLFANMDDEGDYIYVYNREFIQEYSEKCKNPIKNYVYLDAMFFGMSMCCQQLTMSLPTVD
DAKYVYDQLAVIAPLFLALTACTPYLGGFLTETDTRWRVISNSVDCRTEEELSYICKPRY
SGISLYISNELPLKRNYYFYNDVDVILDKNVYDKLKKENADEYLARHIASLFVRDPIVVF
EGSYSERDIATIQKKIMELSNDEDKIKGMVEGSSSNSLSSKVLLDNEDRNKNDSSIKEMN
KSNDNNHNNNCHIEYNNKKDINMNKIYLSDNFEFIEDYEEKVLSSHQHFENFQSTNWNSV
RFKPPPILDNHFKGPSSIGWRVEFRTPDIQITDFENSCVVTLVMLLSKFILKERLNLYIP
MTLLEENLFRASKREALTKEKFYFRKDLSYDTLNNEFEEKSIYDIFFNETNGLFFLCYKY
VDELFKEGLLNQSAKNKIDEYIEFVKQRCSGKICTGAMYLRNFILNHPAYEKNSYINSKI
NYDICKLIADIGKGLIIPQELLGVFVDPYKERIKSDIRQINESQYLKSLAYKYISGEDYT
QYLLLNEVLKDDQDYCTCTRRTIYEESMDNTVEFAKKMYELSA
Inhibitor Adenosine-5'-Diphosphate Drug Info [551391]
BSO Drug Info [534959], [535104]
Buthionine sulfoximine Drug Info [536365]
Cystamine Drug Info [535104]
N-Formylmethionine Drug Info [551393]
Pathways
KEGG Pathway Glutathione metabolism
Metabolic pathways
PathWhiz Pathway Glutamate Metabolism
Glutathione Metabolism
Cysteine Metabolism
WikiPathways Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
Metabolism of amino acids and derivatives
Trans-sulfuration and one carbon metabolism
Trans-sulfuration pathway
Phase II conjugation
Glutathione metabolism
References
Ref 534959Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione. Biochem J. 2000 Mar 1;346 Pt 2:545-52.
Ref 535104The gamma-glutamylcysteine synthetase of Onchocerca volvulus. Mol Biochem Parasitol. 2000 Dec;111(2):243-51.
Ref 536365Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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