Target Information

Target General Infomation
Target ID
T18299
Former ID
TTDI02008
Target Name
CaM kinase II
Target Type
Clinical Trial
Disease Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
BioChemical Class
Kinase
UniProt ID
Q9UQM7||Q13554||Q13557||Q13555
EC Number
EC 2.7.11.17
Drugs and Mode of Action
Drug(s) Rimacalib Drug Info Phase 2 Rheumatoid arthritis [544378]
Inhibitor ABIO 09-01 Drug Info [543440]
compound 15b Drug Info [529370]
compound 27 Drug Info [529373]
KN-93 Drug Info [526252]
Modulator Rimacalib Drug Info [530384], [544378]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway ErbB signaling pathway
Calcium signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Wnt signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Olfactory transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Gastric acid secretion
Amphetamine addiction
Tuberculosis
Proteoglycans in cancer
Glioma
Reactome HSF1-dependent transactivation
Trafficking of AMPA receptors
Ca2+ pathway
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
Interferon gamma signaling
WikiPathways ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
EGF/EGFR Signaling Pathway
Myometrial Relaxation and Contraction Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
References
Ref 544378CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21.
Ref 526252Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem. 2002 Jan 31;45(3):563-6.
Ref 529370Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2404-8.
Ref 529373Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2399-403.
Ref 530384Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. Ann N Y Acad Sci. 2009 Sep;1173:706-11.
Ref 543440(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1558).
Ref 544378CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21.

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