Drug Information

Drug General Information
Drug ID
D0F2ME
Former ID
DNC002498
Drug Name
Acetate Ion
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C2H3O2-
Canonical SMILES
CC(=O)[O-]
InChI
1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1
InChIKey
QTBSBXVTEAMEQO-UHFFFAOYSA-M
PubChem Compound ID
175
PubChem Substance ID
2087, 841348, 5394021, 7885698, 8145449, 8150487, 10533700, 12845679, 14709707, 22390438, 24438552, 39958364, 46505412, 46506148, 49848209, 50073401, 56312825, 57320012, 79796563, 81044483, 103036861, 103810521, 104046195, 104294066, 117359391, 117359632, 125566725, 126677955, 126679034, 126687288, 127259266, 127259267, 127259268, 127259269, 127259270, 127259271, 127259272, 127259273, 127259274, 127259275, 127259276, 127259277, 127259278, 127259279, 127259280, 127259281, 127259282, 127259283, 127259284, 127259285
Target and Pathway
Target(s) D-amino acid aminotransferase Target Info Inhibitor [551393]
MMP-12 Target Info Inhibitor [551393]
Superoxide dismutase [Cu-Zn] Target Info Inhibitor [551393]
4-aminobutyrate aminotransferase, mitochondrial Target Info Inhibitor [551393]
Angiotensin-converting enzyme Target Info Inhibitor [551393]
Glucosamine-6-phosphate synthase Target Info Inhibitor [551393]
Mannose-6-phosphate isomerase Target Info Inhibitor [551393]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Target Info Inhibitor [551393]
mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [551393]
Elastase 1 Target Info Inhibitor [551393]
Alanine racemase,biosynthetic Target Info Inhibitor [551393]
Hypoxanthine-guanine phosphoribosyltransferase Target Info Inhibitor [551393]
Nitric-oxide synthase, endothelial Target Info Inhibitor [551393]
Carbonic anhydrase II Target Info Inhibitor [551393]
Estrogen receptor beta Target Info Inhibitor [551393]
4-hydroxyphenylpyruvate dioxygenase Target Info Inhibitor [551393]
Thioredoxin Target Info Inhibitor [551393]
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase Target Info Inhibitor [551393]
Leukotriene A-4 hydrolase Target Info Inhibitor [551393]
Calmodulin Target Info Inhibitor [551393]
Thymidine monophosphate kinase Target Info Inhibitor [551393]
Aldo-keto reductase family 1 member C3 Target Info Inhibitor [551393]
Phospholipase A2 Target Info Inhibitor [551393]
Beta-lactamase Target Info Inhibitor [551393]
BioCyc Pathway Reactive oxygen species degradationGLUDEG-I-PWY:GABA shunt
Valine degradation
Beta-alanine degradation
4-aminobutyrate degradationPWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY66-375:Leukotriene biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesisLIPASYN-PWY:Phospholipases
KEGG Pathway Peroxisome
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Prion diseaseshsa00250:Alanine, aspartate and glutamate metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
Metabolic pathways
GABAergic synapsehsa04614:Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)hsa04520:Adherens junction
Insulin signaling pathwayhsa00330:Arginine and proline metabolism
Calcium signaling pathway
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa00240:Pyrimidine metabolism
Metabolic pathwayshsa00230:Purine metabolism
Drug metabolism - other enzymes
Metabolic pathwayshsa00330:Arginine and proline metabolism
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathwayhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa04915:Estrogen signaling pathway
Prolactin signaling pathwaymmu00130:Ubiquinone and other terpenoid-quinone biosynthesis
Tyrosine metabolism
Phenylalanine metabolism
Metabolic pathwayshsa00590:Arachidonic acid metabolism
Metabolic pathwayshsa04014:Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Phototransduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Amphetamine addiction
Alcoholism
Pertussis
Tuberculosis
Gliomamtu00240:Pyrimidine metabolism
Metabolic pathwayshsa00140:Steroid hormone biosynthesis
Arachidonic acid metabolism
Ovarian steroidogenesishsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Ras signaling pathway
Fat digestion and absorption
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_8:Wnt Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling PathwayNetPath_14:IL2 Signaling Pathway
RANKL Signaling PathwayNetPath_21:RANKL Signaling Pathway
TSH Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Aminobutyrate degradation
Pyrimidine Metabolism
Gamma-aminobutyric acid synthesisP02739:De novo pyrimidine deoxyribonucleotide biosynthesisP00012:Cadherin signaling pathwayP06959:CCKR signaling map STP00005:Angiogenesis
Endothelin signaling pathway
Interleukin signaling pathway
PI3 kinase pathway
VEGF signaling pathwayP00030:Hypoxia response via HIF activation
Oxidative stress responseP06959:CCKR signaling map ST
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingera_genomic_pathway:Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor networkinsulin_pathway:Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
SHP2 signaling
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha networkp38_mkk3_6pathway:p38 MAPK signaling pathway
TNF receptor signaling pathwaybcr_5pathway:BCR signaling pathway
p38 MAPK signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2 signaling events mediated by PI3K
IFN-gamma pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ErbB1 downstream signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Calcium signaling in the CD4+ TCR pathway
Insulin-mediated glucose transport
N-cadherin signaling events
Cellular roles of Anthrax toxin
Regulation of Ras family activation
Downstream signaling in na&#xef
Fc-epsilon receptor I signaling in mast cells
PathWhiz Pathway Degradation of SuperoxidesPW000002:Aspartate Metabolism
Glutamate Metabolism
Beta-Alanine Metabolism
Valine, Leucine and Isoleucine Degradation
Propanoate MetabolismPW000563:Angiotensin MetabolismPW000010:Arginine and Proline MetabolismPW000160:Pyrimidine MetabolismPW000052:Purine MetabolismPW000052:Purine MetabolismPW000044:Arachidonic Acid MetabolismPW000564:Muscle/Heart ContractionPW000044:Arachidonic Acid Metabolism
Reactome Collagen degradation
Degradation of the extracellular matrixR-HSA-114608:Platelet degranulation
Detoxification of Reactive Oxygen SpeciesR-HSA-2022377:Metabolism of Angiotensinogen to AngiotensinsR-HSA-354192:Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signalingR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-500753:Pyrimidine biosynthesisR-HSA-74217:Purine salvageR-HSA-1222556:ROS production in response to bacteria
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeabilityR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-2559580:Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
The NLRP3 inflammasomeR-HSA-111933:Calmodulin induced events
Platelet degranulation
Translocation of GLUT4 to the plasma membrane
DARPP-32 events
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
RHO GTPases activate IQGAPs
RAF/MAP kinase cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-975634:Retinoid metabolism and transportR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix MetalloproteinasesWP408:Oxidative Stress
Copper homeostasis
Detoxification of Reactive Oxygen Species
Nifedipine Activity
Amyotrophic lateral sclerosis (ALS)
Dopamine metabolism
AGE/RAGE pathway
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP2685:GABA synthesis, release, reuptake and degradation
Alanine and aspartate metabolismWP554:ACE Inhibitor Pathway
Metabolism of Angiotensinogen to AngiotensinsWP481:Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signalingWP727:Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP1851:Metabolism of nucleotidesWP404:Nucleotide Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
Metabolism of nucleotidesWP554:ACE Inhibitor Pathway
EGF/EGFR Signaling Pathway
JAK/STAT
Corticotropin-releasing hormone
Endothelin Pathways
Metabolism of nitric oxide
AngiogenesisWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear ReceptorsWP2884:NRF2 pathway
Nuclear Receptors Meta-Pathway
Human Complement System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TNF alpha Signaling Pathway
Metabolism of nucleotides
Selenium Micronutrient NetworkWP2650:Arachidonic acid metabolism
Eicosanoid SynthesisWP2777:Translocation of GLUT4 to the Plasma Membrane
Visual phototransduction
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by the B Cell Receptor (BCR)
Inositol phosphate metabolism
DAG and IP3 signaling
Opioid Signalling
Muscle contraction
Metabolism of carbohydratesWP702:Metapathway biotransformation
Benzo(a)pyrene metabolism
Arachidonic acid metabolismWP2740:Glycerophospholipid biosynthesis
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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