Drug General Information |
Drug ID |
D0F2ME
|
Former ID |
DNC002498
|
Drug Name |
Acetate Ion
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C2H3O2-
|
Canonical SMILES |
CC(=O)[O-]
|
InChI |
1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1
|
InChIKey |
QTBSBXVTEAMEQO-UHFFFAOYSA-M
|
PubChem Compound ID |
|
PubChem Substance ID |
2087, 841348, 5394021, 7885698, 8145449, 8150487, 10533700, 12845679, 14709707, 22390438, 24438552, 39958364, 46505412, 46506148, 49848209, 50073401, 56312825, 57320012, 79796563, 81044483, 103036861, 103810521, 104046195, 104294066, 117359391, 117359632, 125566725, 126677955, 126679034, 126687288, 127259266, 127259267, 127259268, 127259269, 127259270, 127259271, 127259272, 127259273, 127259274, 127259275, 127259276, 127259277, 127259278, 127259279, 127259280, 127259281, 127259282, 127259283, 127259284, 127259285
|
Target and Pathway |
Target(s) |
D-amino acid aminotransferase |
Target Info |
Inhibitor |
[1]
|
MMP-12 |
Target Info |
Inhibitor |
[1]
|
Superoxide dismutase [Cu-Zn] |
Target Info |
Inhibitor |
[1]
|
4-aminobutyrate aminotransferase, mitochondrial |
Target Info |
Inhibitor |
[1]
|
Angiotensin-converting enzyme |
Target Info |
Inhibitor |
[1]
|
Glucosamine-6-phosphate synthase |
Target Info |
Inhibitor |
[1]
|
Mannose-6-phosphate isomerase |
Target Info |
Inhibitor |
[1]
|
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
Target Info |
Inhibitor |
[1]
|
mRNA of Protein tyrosine phosphatase-1B |
Target Info |
Inhibitor |
[1]
|
Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
Dihydroorotate dehydrogenase, mitochondrial |
Target Info |
Inhibitor |
[1]
|
Elastase 1 |
Target Info |
Inhibitor |
[1]
|
Alanine racemase,biosynthetic |
Target Info |
Inhibitor |
[1]
|
Hypoxanthine-guanine phosphoribosyltransferase |
Target Info |
Inhibitor |
[1]
|
Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
4-hydroxyphenylpyruvate dioxygenase |
Target Info |
Inhibitor |
[1]
|
Thioredoxin |
Target Info |
Inhibitor |
[1]
|
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase |
Target Info |
Inhibitor |
[1]
|
Leukotriene A-4 hydrolase |
Target Info |
Inhibitor |
[1]
|
Calmodulin |
Target Info |
Inhibitor |
[1]
|
Thymidine monophosphate kinase |
Target Info |
Inhibitor |
[1]
|
Aldo-keto reductase family 1 member C3 |
Target Info |
Inhibitor |
[1]
|
Phospholipase A2 |
Target Info |
Inhibitor |
[1]
|
Beta-lactamase |
Target Info |
Inhibitor |
[1]
|
BioCyc Pathway
|
Reactive oxygen species degradationGLUDEG-I-PWY:GABA shunt
|
Valine degradation
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Beta-alanine degradation
|
4-aminobutyrate degradationPWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY66-375:Leukotriene biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Allopregnanolone biosynthesis
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Androgen biosynthesisLIPASYN-PWY:Phospholipases
|
KEGG Pathway
|
Peroxisome
|
Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Prion diseaseshsa00250:Alanine, aspartate and glutamate metabolism
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Valine, leucine and isoleucine degradation
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beta-Alanine metabolism
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Propanoate metabolism
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Butanoate metabolism
|
Metabolic pathways
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GABAergic synapsehsa04614:Renin-angiotensin system
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Chagas disease (American trypanosomiasis)
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Hypertrophic cardiomyopathy (HCM)hsa04520:Adherens junction
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Insulin signaling pathwayhsa00330:Arginine and proline metabolism
|
Calcium signaling pathway
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Phagosome
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Circadian entrainment
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Long-term depression
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Salivary secretion
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)hsa00240:Pyrimidine metabolism
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Metabolic pathwayshsa00230:Purine metabolism
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Drug metabolism - other enzymes
|
Metabolic pathwayshsa00330:Arginine and proline metabolism
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Platelet activation
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Estrogen signaling pathway
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Oxytocin signaling pathwayhsa00910:Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa04915:Estrogen signaling pathway
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Prolactin signaling pathwaymmu00130:Ubiquinone and other terpenoid-quinone biosynthesis
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Tyrosine metabolism
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Phenylalanine metabolism
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Metabolic pathwayshsa00590:Arachidonic acid metabolism
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Metabolic pathwayshsa04014:Ras signaling pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Phosphatidylinositol signaling system
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Oocyte meiosis
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
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Long-term potentiation
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Olfactory transduction
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Phototransduction
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Melanogenesis
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Oxytocin signaling pathway
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Glucagon signaling pathway
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Amphetamine addiction
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Alcoholism
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Pertussis
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Tuberculosis
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Gliomamtu00240:Pyrimidine metabolism
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Metabolic pathwayshsa00140:Steroid hormone biosynthesis
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Arachidonic acid metabolism
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Ovarian steroidogenesishsa00564:Glycerophospholipid metabolism
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Ether lipid metabolism
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Linoleic acid metabolism
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alpha-Linolenic acid metabolism
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Ras signaling pathway
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Fat digestion and absorption
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NetPath Pathway
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IL1 Signaling Pathway
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IL5 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_8:Wnt Signaling PathwayNetPath_16:IL4 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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RANKL Signaling PathwayNetPath_21:RANKL Signaling Pathway
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TSH Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Aminobutyrate degradation
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Pyrimidine Metabolism
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Gamma-aminobutyric acid synthesisP02739:De novo pyrimidine deoxyribonucleotide biosynthesisP00012:Cadherin signaling pathwayP06959:CCKR signaling map STP00005:Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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VEGF signaling pathwayP00030:Hypoxia response via HIF activation
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Oxidative stress responseP06959:CCKR signaling map ST
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Pathway Interaction Database
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingera_genomic_pathway:Validated nuclear estrogen receptor alpha network
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FOXA1 transcription factor networkinsulin_pathway:Insulin Pathway
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Signaling events mediated by TCPTP
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IGF1 pathway
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EGF receptor (ErbB1) signaling pathway
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Posttranslational regulation of adherens junction stability and dissassembly
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PDGFR-beta signaling pathway
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N-cadherin signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
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Validated nuclear estrogen receptor beta network
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Validated nuclear estrogen receptor alpha networkp38_mkk3_6pathway:p38 MAPK signaling pathway
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TNF receptor signaling pathwaybcr_5pathway:BCR signaling pathway
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p38 MAPK signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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IL2 signaling events mediated by PI3K
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IFN-gamma pathway
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Lissencephaly gene (LIS1) in neuronal migration and development
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ErbB1 downstream signaling
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
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Calcium signaling in the CD4+ TCR pathway
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Insulin-mediated glucose transport
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N-cadherin signaling events
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Cellular roles of Anthrax toxin
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Regulation of Ras family activation
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Downstream signaling in naï
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Fc-epsilon receptor I signaling in mast cells
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PathWhiz Pathway
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Degradation of SuperoxidesPW000002:Aspartate Metabolism
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Glutamate Metabolism
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Beta-Alanine Metabolism
|
Valine, Leucine and Isoleucine Degradation
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Propanoate MetabolismPW000563:Angiotensin MetabolismPW000010:Arginine and Proline MetabolismPW000160:Pyrimidine MetabolismPW000052:Purine MetabolismPW000052:Purine MetabolismPW000044:Arachidonic Acid MetabolismPW000564:Muscle/Heart ContractionPW000044:Arachidonic Acid Metabolism
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Reactome
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Collagen degradation
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Degradation of the extracellular matrixR-HSA-114608:Platelet degranulation
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Detoxification of Reactive Oxygen SpeciesR-HSA-2022377:Metabolism of Angiotensinogen to AngiotensinsR-HSA-354192:Integrin alphaIIb beta3 signaling
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Regulation of IFNG signaling
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Regulation of IFNA signaling
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Growth hormone receptor signalingR-HSA-1222556:ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-500753:Pyrimidine biosynthesisR-HSA-74217:Purine salvageR-HSA-1222556:ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeabilityR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxideR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-2559580:Oxidative Stress Induced Senescence
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Detoxification of Reactive Oxygen Species
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TP53 Regulates Metabolic Genes
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The NLRP3 inflammasomeR-HSA-111933:Calmodulin induced events
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Platelet degranulation
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Translocation of GLUT4 to the plasma membrane
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DARPP-32 events
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Inactivation, recovery and regulation of the phototransduction cascade
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FCERI mediated Ca+2 mobilization
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Ca2+ pathway
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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Smooth Muscle Contraction
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VEGFR2 mediated vascular permeability
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VEGFR2 mediated cell proliferation
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RHO GTPases activate IQGAPs
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RAF/MAP kinase cascade
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Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-975634:Retinoid metabolism and transportR-HSA-1482788:Acyl chain remodelling of PC
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Acyl chain remodelling of PE
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Acyl chain remodelling of PI
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WikiPathways
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TGF beta Signaling Pathway
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Degradation of collagen
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Matrix MetalloproteinasesWP408:Oxidative Stress
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Copper homeostasis
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Detoxification of Reactive Oxygen Species
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Nifedipine Activity
|
Amyotrophic lateral sclerosis (ALS)
|
Dopamine metabolism
|
AGE/RAGE pathway
|
Folate Metabolism
|
Vitamin B12 Metabolism
|
Selenium Micronutrient NetworkWP2685:GABA synthesis, release, reuptake and degradation
|
Alanine and aspartate metabolismWP554:ACE Inhibitor Pathway
|
Metabolism of Angiotensinogen to AngiotensinsWP481:Insulin Signaling
|
Growth hormone receptor signaling
|
Leptin signaling pathway
|
Interferon gamma signaling
|
Interferon alpha/beta signaling
|
Integrin alphaIIb beta3 signalingWP727:Monoamine Transport
|
Myometrial Relaxation and Contraction Pathways
|
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
Spinal Cord Injury
|
Alzheimers Disease
|
Effects of Nitric Oxide
|
Serotonin Transporter ActivityWP1851:Metabolism of nucleotidesWP404:Nucleotide Metabolism
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Mesodermal Commitment Pathway
|
Endoderm Differentiation
|
Metabolism of nucleotidesWP554:ACE Inhibitor Pathway
|
EGF/EGFR Signaling Pathway
|
JAK/STAT
|
Corticotropin-releasing hormone
|
Endothelin Pathways
|
Metabolism of nitric oxide
|
AngiogenesisWP2770:Reversible Hydration of Carbon Dioxide
|
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
|
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP706:SIDS Susceptibility Pathways
|
Ovarian Infertility Genes
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Integrated Pancreatic Cancer Pathway
|
Nuclear ReceptorsWP2884:NRF2 pathway
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Nuclear Receptors Meta-Pathway
|
Human Complement System
|
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
|
TNF alpha Signaling Pathway
|
Metabolism of nucleotides
|
Selenium Micronutrient NetworkWP2650:Arachidonic acid metabolism
|
Eicosanoid SynthesisWP2777:Translocation of GLUT4 to the Plasma Membrane
|
Visual phototransduction
|
Fc epsilon receptor (FCERI) signaling
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
Signaling by the B Cell Receptor (BCR)
|
Inositol phosphate metabolism
|
DAG and IP3 signaling
|
Opioid Signalling
|
Muscle contraction
|
Metabolism of carbohydratesWP702:Metapathway biotransformation
|
Benzo(a)pyrene metabolism
|
Arachidonic acid metabolismWP2740:Glycerophospholipid biosynthesis
|
References |
REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |