Target Information

Target General Infomation
Target ID
T81100
Former ID
TTDC00336
Target Name
mRNA of sodium-glucosetransporter-2
Gene Name
SLC5A2
Synonyms
mRNA of Low affinity sodium-glucose cotransporter; mRNA of Na(+)/glucose cotransporter 2; mRNA of SGLT2; mRNA of SLC5A2; mRNA of Sodium/glucosecotransporter 2; mRNA of Solute carrierfamily 5 member 2; SLC5A2
Target Type
Clinical Trial
Disease Type 2 diabetes [ICD9: 250; ICD10: E11]
Function
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
BioChemical Class
Solute:sodium symporter
Target Validation
T81100
UniProt ID
P31639
Sequence
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
Drugs and Mode of Action
Drug(s) ISIS-SGLT2 Drug Info Phase 1 Type 2 diabetes [551052]
Inhibitor 10-methoxy-N(1)-methylburnamine-17-O-veratrate Drug Info [530756]
ACEROGENIN B Drug Info [530603]
Acerogenin C Drug Info [530603]
Alstiphyllanine D Drug Info [530756]
Alstiphyllanine E Drug Info [530756]
Alstiphyllanine F Drug Info [530756]
Burnamine-17-O-3',4',5'-trimethoxybenzoate Drug Info [530756]
FORMONONETIN Drug Info [528742]
KURAIDIN Drug Info [528742]
KURARINONE Drug Info [528742]
Kushenol N Drug Info [528742]
MAACKIAIN Drug Info [528742]
O-spiroketal glucoside Drug Info [530988]
SERGLIFLOZIN A Drug Info [530750]
Sophoraflavanone G Drug Info [528742]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
Ref 528742Bioorg Med Chem. 2007 May 15;15(10):3445-9. Epub 2007 Mar 12.Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
Ref 530603Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4. Epub 2009 Dec 11.Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.
Ref 530750Bioorg Med Chem. 2010 Mar 15;18(6):2178-94. Epub 2010 Feb 4.Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners.
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Ref 530988Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. Epub 2010 Apr 29.ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).

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